Sleep patterns in Kleine-Levin syndrome

Lavie, Peretz; Gadoth, Natan; Gordon, Carlos R.; Goldhammer, G; Bechar, M

doi:10.1016/0013-4694(79)90287-6

Cited by 34 publications

(8 citation statements)

References 5 publications

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“…In comparison with Lavie [10], we did not prove reduced REM latency. Differences between PSG findings in the literature and the presented case rise up the question whether they would be caused by the inter-individual differences of the cases of RH or differences in electrophysiologic methodology across the studies, especially the definition of the nighttime sleep in a patient who sleeps 16-18 hours per a 24 hour period.…”

Section: Discussioncontrasting

confidence: 98%

Sleep evaluation in the symptomatic episode of recurrent hypersomnia

Feketeová

Tormašiová

2007

Open Medicine

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AbstractRecurrent hypersomnia (RH) is a rare disorder characterized by episodes of hypersomnia, variously accompanied by behavioural and cognitive disturbances, compulsive eating behaviour and hypersexuality. Electrophysiologic evaluation of the sleep during symptomatic and asymptomatic periods of RH distinguishes RH from other primary sleep or mental disorders. Unique polysomnographic findings during the hypersomniac attack lasting 96 hours in a 16-year-old boy affected with primary RH are presented in this paper.

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Section: Discussioncontrasting

confidence: 98%

Sleep evaluation in the symptomatic episode of recurrent hypersomnia

Feketeová

Tormašiová

2007

Open Medicine

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“…We previously documented the normal sleep structure with decreased sleep efficacy caused by frequent awakening from sleep stage 2 in a small number of patients (Lavie et al. 1981).…”

Section: Discussionmentioning

confidence: 99%

“…Since Critchley’s review, only a few case reports have added new data on the syndrome, particularly with respect to sleep structure (Lavie et al. 1979, 1981), and hormonal secretory patterns (Chesson et al.…”

Section: Introductionmentioning

confidence: 99%

Clinical and polysomnographic characteristics of 34 patients with Kleine–Levin syndrome

Gadoth

Kesler

Vainstein

et al. 2001

Journal of Sleep Research

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There is only scant information on sleep characteristics and long-term follow-up in patients with Kleine-Levin syndrome (KLS). This study describes the clinical course, results of polysomnography and long-term follow-up in a relatively large group of patients with KLS. During the years 1982-97, we encountered 34 patients (26 males and eight females) with KLS. We were able to obtain the original polysomnographs from 28 males and four females. In 25 patients, data regarding their present state of health were obtained. Fourteen agreed to be present at a detailed interview and examination while 11 gave the information by phone. The mean age at onset was 15.8 +/- 2.8 years and the mean diagnostic delay, 3.8 +/- 4.2 years. The mean duration of a single hypersomnolent attack was 11.5 +/- 6.6 days. The main abnormal findings extracted out of 35 polysomnographs obtained from 32 patients during and/or in-between attacks included: decreased sleep efficiency, and frequent awakenings from sleep stage 2. All 25 patients reported present perfect health, with no evidence of behavioral or endocrine dysfunction. In adolescents with periodic hypersomnia, the diagnosis of KLS should be explored. Sleep recordings during a hypersomnolent period will often show frequent awakenings from sleep stage 2. The long-term prognosis is excellent.

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“…Total sleeping time of normal subjects was composed of 5-10% of stage 1, 50% of stage 2, 20% of stage 3-4, and 20%-25% of REM sleep. Sleep pattern of periodic hypersomnia was reported as follows11 12; total sleeping time and the percentage of REM sleep are identical to normal controls, whereas the percentage of stage 2 is decreased and that of stage 3/4 is increased. Her actual sleep time was 77% of total recording time, which was obviously prolonged compared with periodic hypersomnia and healthy subjects.…”

Section: Discussionmentioning

confidence: 86%

Novel chromosomal abberation in a patient with a unique sleep disorder

Hasegawa¹,

Morishita

Suzumura

1998

Journal of Neurology, Neurosurgery & Psychiatry

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A 45 year old woman presenting with periodic hypersomnia for 17 years is reported on. She would sleep for three weeks followed by the same period awake. Polysomnography in the somnolent period disclosed an excess of total sleeping time with remarkably increased stage 1, 3/4, and REM sleep, without cataplexy or sleep paralysis. HLA typing was incompatible with narcolepsy or REM sleep behavioural disorder. Her chromosomes showed premature centromere division with chromatid puYng in areas of constitutive heterochromatin, which is exclusively found in the syndrome of infants termed Roberts' syndrome/SC phocomelia. Other laboratory findings were not normal. It is suggested that the present case is a novel sleep disorder related to a unique chromosomal aberration. (J Neurol Neurosurg Psychiatry 1998;64:113-116) Premature centromere division with chromatid puYng is a rare chromosomal aberration which is exclusively found in Roberts' syndrome.

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Sleep patterns in Kleine-Levin syndrome

Cited by 34 publications

References 5 publications

Sleep evaluation in the symptomatic episode of recurrent hypersomnia

Sleep evaluation in the symptomatic episode of recurrent hypersomnia

Clinical and polysomnographic characteristics of 34 patients with Kleine–Levin syndrome

Novel chromosomal abberation in a patient with a unique sleep disorder

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