Sleep investigations in erectile dysfunction

Mann, Klaus; Pankok, Justus; Connemann, Bernhard J.; Sohn, Michael; Thüroff, Joachim W.; Benkert, Otto

doi:10.1016/j.jpsychires.2004.05.007

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…In the present study, both RLS and other sleep disorders were independently associated with ED, and the combination of other sleep disorders with RLS further increased the risk. These findings support the assumption that assessment of RLS and sleep disorders may provide a useful indicator for earlier detection of ED (35)(36)(37)(38). It can be hypothesized that medical treatment of disorders such as insomnia or RLS may improve sleep quality and psychogenic factors and thus erectile function.…”

Section: Discussionsupporting

confidence: 81%

Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction

Li¹,

Batool-Anwar²,

Kim³

et al. 2013

American Journal of Epidemiology

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In our previous cross-sectional study, we found that restless legs syndrome (RLS) was associated with erectile dysfunction (ED). Thus, we conducted a prospective study to examine whether RLS was associated with a higher risk of developing ED based on 6 years of follow-up among 10,394 men (mean age = 63.4 years) in the Health Professionals Follow-up Study. RLS was assessed in 2002 using a set of standardized questions recommended by the International RLS Study Group. Erectile function was assessed by means of questionnaires in 2000, 2004, and 2008. We identified 1,633 incident ED cases. Men with RLS were more likely to develop ED (relative risk = 1.38, 95% confidence interval: 1.14, 1.68; P = 0.001) than were those without the syndrome, after adjustment for potential confounders, such as age, body mass index, smoking, physical activity, other sleep disorders, and snoring status. A higher frequency of RLS symptoms was also associated with an increased risk of ED (P(trend) = 0.001). In conclusion, men with RLS had a higher risk of ED, and the magnitude of the risk increased with a higher frequency of RLS symptoms. Combinations of other sleep disorders with RLS further increased the risk of ED.

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Section: Discussionsupporting

confidence: 81%

Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction

Li¹,

Batool-Anwar²,

Kim³

et al. 2013

American Journal of Epidemiology

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“…We chose rigidity due to its relevance as a parameter for intracavernous pressure assessment and because this research focused on increases in penile blood flow rather than erectile dysfunction. 25 According to Licht et al, base rigidity is also more accurate than tip measurements to evaluate erectile function. 26 2) Patients with lung involvement were not withdrawn from study because pulmonary abnormalities occur in approximately 90% of adults with SCD.…”

Section: Discussionmentioning

confidence: 99%

Priapism is Associated with Sleep Hypoxemia in Sickle Cell Disease

et al. 2012

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“…An individual that has difficulties initiating or maintaining erections during wakefulness and that otherwise has entirely normal erections during REM sleep is considered to have a psychogenic cause of the erectile failure, because the erectile physiology presumably remains intact. Mann et al [78] found in 24 male patients with psychogenic ED (assessment of nocturnal erections) a shortening of REM latency compared with healthy controls. Spectral analysis in the sleep laboratory revealed a reduced Q power for all sleep stages and a reduced ∂ power for stage II and slow-wave sleep in the patients.…”

Section: Physiology Of Sresmentioning

confidence: 99%

“…Mann et al. [78] found in 24 male patients with psychogenic ED (assessment of nocturnal erections) a shortening of REM latency compared with healthy controls. Spectral analysis in the sleep laboratory revealed a reduced Θ power for all sleep stages and a reduced ∂ power for stage II and slow‐wave sleep in the patients.…”

Section: Physiology Of Sresmentioning

confidence: 99%

Testosterone and Sleep-Related Erections: An Overview*

Montorsi¹,

Oettel²

2005

The Journal of Sexual Medicine

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Montorsi F, Oettel M. Testosterone and sleep-related erections: an overview.J Sex Med 2005;2:771–784 Sleep-related erections have been reported to occur from the intrauterine life to senescence. It has been speculated that the main function of nocturnal erections is to provide adequate engorgement of the corpora cavernosa, which then leads to increased tissue oxygenation. This is in turn to prevent cavernous fibrosis, the histopathological basis for corporeal venoocclusive dysfunction, which probably is the most common cause of organic erectile dysfunction. It has been suggested that sleep-related erections are triggered by the release of nitric oxide by the nitrergic nerve fibers within the cavernous nerves. Androgens regulate this mechanism as well as some other non-nitrergic processes within the corpora cavernosa and within the central nervous system. By contrast, the erectile response to tactile or visual erotic stimuli in wakefulness predominantly involves an androgen-independent system, although it may, at least to a certain degree, also be influenced by androgen-sensitive mechanisms. No doubt, androgens are key players in the physiology of nocturnal erections, and the availability of new, user-friendly testosterone preparations such as transdermal gel and intramuscularly administered testosterone undecanoate stimulates further investigations on this field. The prospect that the quality of sleep may also be improved by an androgen therapy administered to improve sleep-related erections in hypogonadal men needs further basic research and appropriate clinical studies.

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Sleep investigations in erectile dysfunction

Cited by 7 publications

References 44 publications

Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction

Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction

Priapism is Associated with Sleep Hypoxemia in Sickle Cell Disease

Testosterone and Sleep-Related Erections: An Overview*

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