Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction

Li, Yanping; Batool-Anwar, Salma; Kim, Sehee; Rimm, Eric B.; Ascherio, Alberto; Gao, Xiang

doi:10.1093/aje/kws364

Cited by 14 publications

(5 citation statements)

References 43 publications

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“…Second, since we only ascertained ED via a single self-reported questionnaire on ED onset during approximately 7 years after blood draw, we cannot exclude the recall bias as a possible explanation of our results. Furthermore, our assessment of ED has not been validated; however, we note that a prior report using these data [ 22 ] were consistent with what has been found in other studies [ 15 , 23 ]. Nonetheless, these two methodological weaknesses regarding the ascertainment of ED may lead to misclassification between incident ED and healthy controls.…”

Section: Resultssupporting

confidence: 86%

Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study

et al. 2015

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BackgroundExisting epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress and ED in prospective setting among a relatively large sample size of men.MethodsWe conducted the prospective study among 917 men ages between 47 and 80 years at the time of blood draw, which is a part of nested prospective case–control study of prostate cancer in the Health Professionals Follow-up Study. Plasma fluorescent oxidation products (FlOPs), a global biomarker for oxidative stress, were measured at three excitation/emission wavelengths (360/420 nm named as FlOP_360; 320/420 nm named as FlOP_320 and 400/475 nm named as FlOP_400).ResultsApproximately 35 % of men developed ED during follow-up. We did not find an independent association between FlOP_360, FlOP_320, FlOP_400 and risk of ED in the multivariable adjusted model (Tertile 3 vs. tertile 1: odds ratio [OR] = 0.90, 95 % confidence interval [CI] = 0.61-1.34, Ptrend = 0.54 for FlOP_360; OR = 0.73, 95 % CI = 0.49-1.07, Ptrend = 0.27 for FlOP_320; and OR = 0.98, 95 % CI = 0.66-1.45, Ptrend = 0.72 for FlOP_400). Further analysis of the association between FlOPs and ED in the fasting samples or controls only (free of prostate cancer incidence) did not change the results appreciably.ConclusionsPlasma FlOPs were not associated with the risk of ED, suggesting oxidative stress may not be an independent risk factor for ED.Electronic supplementary materialThe online version of this article (doi:10.1186/s12894-015-0083-9) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 86%

Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study

et al. 2015

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“…This imbalance of distribution is in accordance with previous findings that men with RLS have a higher risk for developing ED. Furthermore, the magnitude of that risk can also increase in combination with other sleep disorders such as OSA [35,36].…”

Section: Discussionmentioning

confidence: 99%

Impaired Vigilance Is Associated with Erectile Dysfunction in Patients with Sleep Apnea

Popp

Kleemann

Burger

et al. 2015

The Journal of Sexual Medicine

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Introduction Erectile dysfunction (ED) is frequent in patients with obstructive sleep apnea (OSA) and may act as a surrogate of endothelial dysfunction. Furthermore, impairments of vigilance and sustained attention are also commonly associated with OSA. Aim The purpose of this study was to evaluate whether there is an association between ED and sustained attention deficits. Methods A prospective cross-sectional cohort of 401 male in-patients undergoing diagnostic polysomnography for suspected OSA and a 25-minute sustained attention test was analyzed. ED was assessed using the 15-item International Index of Erectile Function (IIEF-15) questionnaire. The Epworth Sleepiness Scale (ESS) served as a measure of daytime sleepiness. Main Outcome Measure Severity of impaired erectile function (EF) assessed by the IIEF-15, core task parameters of the sustained attention test (i.e., CR: correct reactions; V-CR: variation of correct reactions, CE: commission errors, RT: reaction time; V-RT: variation of reaction times). Results Three hundred eighty-one consecutive patients presenting for in-lab polysomnography were included in the analysis. Impaired EF was diagnosed in 246 patients (65%). With increasing impairment of EF, patients scored significantly worse in all vigilance test parameters and demonstrated more severely diminished vigilance (normal EF: 11.9%, moderately impaired EF: 24.1%, and severely impaired EF: 34.9%). Multivariate regression analyses including established risk factors for ED, OSA, or sleepiness revealed a significant independent association between lower scores for EF and impairments on the following vigilance test variables: odds ratio (95% confidence interval) for V-CR: 0.52 (0.34–0.81), CE: 0.87 (0.80–0.95), and V-RT: 0.91 (0.87–0.96). The ESS was independently associated with both measures of performance instability: odds ratio for V-CR: 6.94 (2.97–16.23) and V-RT: 1.28 (1.14–1.44). Conclusions In OSA patients, the severity of impaired EF was associated with impaired vigilance performance, independent of other known risk factors for ED or OSA and not mediated by sleepiness. Potentially, the findings suggest a direct relationship between vascular or endothelial dysfunction and impairments in both EF and neurobehavioral cognitive function.

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“…The mechanism of interaction has not been clarified yet, but it may be because RLS and ED have similar biological processes, including autonomic dysfunction and dopamine deficiency. A 6-year prospective study found that RLS was a risk factor for developing ED with a relative risk of 1.33, and the frequency of RLS symptoms had a linear relationship with the magnitude of the that risk [112]. In a recent case-control study with 50 subjects each, Kurt [113] reported that not only ED but also premature ejaculation is more common in men with RLS than in controls.…”

Section: Main Bodymentioning

confidence: 99%

Sleep, Sleep Disorders, and Sexual Dysfunction

Cho

Duffy

2019

World J Mens Health

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Good sleep is necessary for good health. Sleep health is increasingly recognized as important for physical and mental health by both the medical profession and the general public, and there is great interest in how to avoid and treat sleep disorders and problems. Recent research indicates that insufficient sleep, disrupted sleep, and sleep disorders affect many aspects of human health including sexual function. In fact, patients with urological disorders or erectile dysfunction (ED) may have a sleep disorder that contributes to their urological or sexual dysfunction. Obstructive sleep apnea, insomnia, shift work disorder, and restless legs syndrome are all common sleep disorders and are associated with ED and/or other urological disorders. Therefore, careful attention should be paid to the diagnosis and treatment of concomitant sleep disorders in patients with sexual dysfunction. In this review, we provide an overview of what sleep is and how it is assessed in the clinic or laboratory; our current understanding of the functions of sleep and sleep health; a description of common sleep disorders, as well as how they are diagnosed and treated; and how sleep and its disorders are associated with male sexual dysfunction. Sleep is considered to be a 'third pillar of health', along with diet and exercise. With an understanding of common sleep disorders and how they can impact male sexual function, the urologist can ensure that sleep disorders are considered as a contributor to sexual dysfunction in their patients in order to provide them with the optimal treatment for overall health.Keywords: Erectile dysfunction; Sexual dysfunctions, psychological; Sleep; Sleep wake disorders; Testosterone This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prospective Study of Restless Legs Syndrome and Risk of Erectile Dysfunction

Cited by 14 publications

References 43 publications

Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study

Association between plasma fluorescent oxidation products and erectile dysfunction: A prospective study

Impaired Vigilance Is Associated with Erectile Dysfunction in Patients with Sleep Apnea

Sleep, Sleep Disorders, and Sexual Dysfunction

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