Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia

Hachul, Helena; Brandão, Letícia Campos; D’Almeida, Vânia; Grego, Bruno H.C.; Bittencourt, Lia; Tufik, Sérgio; Baracat, Edmund Chada

doi:10.1080/13697130600871947

Cited by 87 publications

(44 citation statements)

References 31 publications

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“…As also observed in a study by Vagiakis et al (31), REM sleep latency was also longer in women than in men. Taken altogether, differences between genders could be due to the effects of cyclic levels of female reproductive hormones on sleep (20,32). Conceivably, this suggests that women are either more susceptible to clinical symptoms deriving from inadequate sleep or are more likely to report symptoms in general (33).…”

Section: Discussionmentioning

confidence: 99%

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Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory

Silva

Andersen

Mello

et al. 2008

Braz J Med Biol Res

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Our objective was to examine the effect of gender on the sleep pattern of patients referred to a sleep laboratory. The data (questionnaires and polysomnographic recordings) were collected from a total of 2365 patients (1550 men and 815 women). The polysomnography permits an objective assessment of the sleep pattern. We included only polysomnography exams obtained with no more than one recording system in order to permit normalization of the data. Men had a significantly higher body mass index than women (28.5 ± 4.8 vs 27.7 ± 6.35 kg/m 2 ) and had a significantly higher score on the Epworth Sleepiness Scale (10.8 ± 5.3 vs 9.5 ± 6.0), suggesting daytime sleepiness. Women had a significantly higher sleep latency than men, as well as a higher rapid eye movement (REM) latency. Men spent more time in stages 1 (4.6 ± 4.1 vs 3.9 ± 3.8) and 2 (57.0 ± 10.5 vs 55.2 ± 10.1) of non-REM sleep than women, whereas women spent significantly more time in deep sleep stages (3 and 4) than men (22.6 ± 9.0 vs 19.9 ± 9.0). The apnea/hypopnea and arousal indexes were significantly higher and more frequent in men than in women (31.0 ± 31.5 vs 17.3 ± 19.7). Also, periodic leg movement index did not differ significantly between genders, but rather differed among age groups. We did not find significant differences between genders in the percentage of REM sleep and sleep efficiency. The results of the current study suggest that there are specific gender differences in sleep pattern.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, nightmares were twice as prevalent in women as in men (19). The reasons for such discrepancies are attributed to hormonal fluctuations over the menstrual or estrous cycles, a factor that has been associated with sleep variations in both humans and rats (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory

Silva

Andersen

Mello

et al. 2008

Braz J Med Biol Res

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“…Two studies in rats found that males display significantly more paradoxical sleep during both the day and the night than females [29,30], whereas another study in Swiss-Webster mice reported a slight diurnal sex difference in the amount of paradoxical and nonparadoxical sleep [31]. Additionally, hormonal fluctuation is a factor that has been associated with sleep variations in both humans and rats [32,33], although little information is available about how it affects sleep [34]. From a clinical perspective, women and men sleep differently and recover differently from sleep deprivation [35].…”

Section: Discussionmentioning

confidence: 99%

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Maragno-Correa

Patti

Zanin

et al. 2013

Neuroimmunomodulation

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Objectives: Sleep deprivation is a growing public health hazard, yet it is still under-recognized. Sleep disorders and disruption of sleep patterns may compromise the immune function and adversely affect host resistance to infectious diseases. This is a particular risk in cancer patients, who report a high frequency of sleep disturbances. The present study investigated the effects of sleep deprivation on the development of Ehrlich ascitic tumors (EAT) in female BALB/c mice. Our study also evaluated whether EAT would induce alterations in sleep pattern. Spleen lymphocyte cell populations and mortality were also quantified. Methods: Female BALB/c mice were intraperitoneally inoculated with EAT cells. Immediately after the inoculation procedure, animals were sleep deprived for 72 h. Ten or 15 days after inoculation, the number of tumoral cells was quantified and the lymphocytic cell population in the spleen was characterized by flow cytometry. In addition, the effect of sleep deprivation on EAT-induced mortality was quantified and the influence of EAT on sleep patterns was determined. Results: Sleep deprivation did not potentiate EAT growth, but it significantly increased mortality. Additionally, both EAT and sleep deprivation decreased frequencies of splenic CD4+, CD8+ and CD19+ cells. With respect to sleep patterns, EAT significantly enhanced paradoxical sleep time. Conclusions: Although sleep deprivation did not potentiate EAT growth, it decreased the survival of female tumor-bearing mice.

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“…However, several studies have also linked oxidative stress with insomnia. For example, levels of thiobarbituric acid reactive substances were elevated in postmenopausal women with insomnia, although blood concentrations of catalase, superoxide dismutase, and glutathione were found to be normal (Hachul de Campos et al, 2006). In an investigation on participants with primary insomnia, significantly lower GSH-Px (selenium-containing antioxidant enzyme) activity and higher MDA levels were found compared with controls (Gulec et al, 2012).…”

Section: Sleep and Its Effect On Oxidative Stressmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

507

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia

Cited by 87 publications

References 31 publications

Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory

Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

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