Sleep Disturbances in Patients with Asperger Syndrome Related to the Severity of their Symptoms

Cebreros-Paniagua, Rodolfo; Ayala‐Guerrero, Fructuoso; Salgado, Erik Leonardo Mateos

doi:10.1007/s41782-020-00104-6

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…Furthermore, the speed of information processing in children, defined as the time it takes to solve a given problem, has been positively correlated with the density of slow spindles by some authors. In contrast, no correlation has been observed with fast spindles, which could indicate a relationship between slow spindles and cognitive development in children [21,26].…”

Section: Discussionmentioning

confidence: 83%

“…In our study, we focused on analyzing sleep spindles. These, generated by the interaction between the thalamus and cortex, are sleep stabilizers involved in synaptic plasticity, learning, and memory consolidation [21,22]. In young adults, symmetrical sleep spindles between the hemispheres have been correlated with improved task attention [7,9].…”

Section: Discussionmentioning

confidence: 99%

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Semi-Automatic Analysis of Specific Electroencephalographic Patterns during NREM2 Sleep in a Pediatric Population after SARS-CoV-2 Infection

Di Bella,

Attardi,

Butera

et al. 2024

JPM

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The post-COVID-19 condition is defined by the World Health Organization as the persistence of symptoms or development of new symptoms three months after the initial SARS-CoV-2 infection, lasting for at least two months without a clear explanation. Neuropsychiatric disorders associated with this condition include asthenia, memory and concentration problems, and sleep disturbances. Our study aims to investigate sleep patterns following SARS-CoV-2 infection using EEG findings and a sleep quality questionnaire completed by parents (Sleep Disturbance Scale for Children—SDSC). Notably, our investigation is based on a convenience sample. The patients in our sample, aged 1 to 14 years, are not currently taking any medications; rather, they are undergoing follow-up assessments at the Child Neuropsychiatry department of the University Hospital of Messina for neurodevelopmental evaluations. Specifically, we are analyzing amplitude and power spectrum data in the first five minutes of NREM2 sleep, calculated from EEG recordings obtained via bipolar leads within three months after the onset of the disease. These results will be compared with controls performed on the same subjects in the six months preceding the infection. The focus of the study was sleep spindles, which are generated by the thalamocortical systems and play a role in sleep modulation, memory, and learning. Preliminary analysis suggests a predominant increase in the slow component of the spindles in the right-frontal lead.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Semi-Automatic Analysis of Specific Electroencephalographic Patterns during NREM2 Sleep in a Pediatric Population after SARS-CoV-2 Infection

Di Bella,

Attardi,

Butera

et al. 2024

JPM

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“…The reduction of this latency in the group with TD sufficed to significantly distinguish it from the group with ASD in the second PSG recording. Studies have reported that REM sleep latency differs between patients with ASD and control groups with TD and is usually longer in patients (Cebreros-Paniagua, Ayala-Guerrero, & Mateos-Salgado, 2020;Giannotti, Cortesi, Cerquiglini, Vagnoni, & Valente, 2011;Miano et al, 2007), while others have found no differences between the two groups (Bruni et al, 2007;Malow et al, 2006). Since this variable did not change in the group with ASD between both PSG recordings, then the FNE can be said not to alter REM sleep latency in this type of patient.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of the first-night effect of polysomnographic recording on cardiac autonomic activity in children with autism spectrum disorder

et al. 2021

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Introduction. The first night effect (FNE) is the tendency to have lower than usual sleep quality and quantity during the first polysomnography (PSG) recording, which alters sleep architecture. The FNE occurs in autism spectrum disorder (ASD), with studies suggesting that cardiac autonomic dysregulation is altered in patients with this illness. Objective. To determine whether the FNE influences the autonomic activity of ASD and typically developing (TD) children. Method. Two PSGs were recorded in 13 ASD and 13 TD children. The FNE was evaluated with eight sleep variables and autonomic activity through respiratory sinus arrhythmia (RSA) and low frequency (LF). Statistical analyses included intra- and inter-subject comparisons. Results. The FNE was present in both groups and affected more sleep variables in the ASD group. There were no significant differences between both recordings in RSA and LF. Inter-subject comparison showed significant differences in certain sleep variables, mainly during the first night. A comparison of RSA and LF between N2 and N3 stages and REM sleep showed that the TD group had significant differences in both measures whereas the ASD group only did so in the LF the first night. Discussion and conclusion. The influence of the FNE on the quantitative characteristics of sleep is corroborated in ASD and TD children, but not in RSA or LF. When the activity of the RSA and LF between sleep stages was considered, a different pattern was observed between the two PSG recordings.

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“…Importantly, both spindles and SO have shown inherent alterations in a variety of neurodevelopmental and psychiatric conditions including ASD (10) (11) (12) (13) (14) (15) (16) (17) (18) (19) (20), ADHD (21) (22) (23), schizophrenia (24) (25) (26) (27), bipolar disorder (28) and others (29).…”

Section: Introductionmentioning

confidence: 99%

“…Spindles and SO, influenced by the efficiency of their coupling, are postulated to promote memory consolidation and studies have shown that entrainment of these rhythms via transcranial electrical stimulation can improve performance on working memory tasks in a variety of clinical populations (8) (9). Importantly, both spindles and SO have shown inherent alterations in a variety of neurodevelopmental and psychiatric conditions including ASD (10) (11) (12) (13) (14) (15) (16) (17) (18) (19) (20), ADHD (21) (22) (23), schizophrenia (24) (25) (26) (27), bipolar disorder (28) and others (29).…”

Section: Introductionmentioning

confidence: 99%

Spindle Chirp and other Sleep Oscillatory Features in Young Children with Autism

Cumming

Kozhemiako

Thurm

et al. 2023

Preprint

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Objectives: To determine whether spindle chirp and other sleep oscillatory features differ in young children with and without autism. Methods: Automated processing software was used to re-assess an extant set of polysomnograms representing 121 children (91 with autism [ASD], 30 typically-developing [TD]), with an age range of 1.35-8.23 years. Spindle metrics, including chirp, and slow oscillation (SO) characteristics were compared between groups. SO and fast and slow spindle (FS, SS) interactions were also investigated. Secondary analyses were performed assessing behavioural data associations, as well as exploratory cohort comparisons to children with non-autism developmental delay (DD). Results: Posterior FS and SS chirp was significantly more negative in ASD than TD. Both groups had comparable intra-spindle frequency range and variance. Frontal and central SO amplitude were decreased in ASD. In contrast to previous manual findings, no differences were detected in other spindle or SO metrics. The ASD group displayed a higher parietal coupling angle. No differences were observed in phase-frequency coupling. The DD group demonstrated lower FS chirp and higher coupling angle than TD. Parietal SS chirp was positively associated with full developmental quotient. Conclusions: For the first time spindle chirp was investigated in autism and was found to be significantly more negative than in TD in this large cohort of young children. This finding strengthens previous reports of spindle and SO abnormalities in ASD. Further investigation of spindle chirp in healthy and clinical populations across development will help elucidate the significance of this difference and better understand this novel metric.

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Sleep Disturbances in Patients with Asperger Syndrome Related to the Severity of their Symptoms

Cited by 3 publications

References 23 publications

Semi-Automatic Analysis of Specific Electroencephalographic Patterns during NREM2 Sleep in a Pediatric Population after SARS-CoV-2 Infection

Semi-Automatic Analysis of Specific Electroencephalographic Patterns during NREM2 Sleep in a Pediatric Population after SARS-CoV-2 Infection

Evaluation of the first-night effect of polysomnographic recording on cardiac autonomic activity in children with autism spectrum disorder

Spindle Chirp and other Sleep Oscillatory Features in Young Children with Autism

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