Sleep Disturbances and Atopic Dermatitis: Relationships, Methods for Assessment, and Therapies

Bawany, Fatima; Northcott, Carrie A.; Beck, Lisa A.; Pigeon, Wilfred R.

doi:10.1016/j.jaip.2020.12.007

Cited by 51 publications

(60 citation statements)

References 188 publications

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“…Previous studies have reported the association of sleep disturbance with child atopic dermatitis 8 9 and adult atopic dermatitis. 10 11 Sleep-related impairment and sleep disturbance are known to be associated with the severity of atopic dermatitis. Sleep disturbance is a critical problem in allergic rhinitis 12 13 14 and asthma patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Quality of Life and Mental Health in Patients With Atopic Dermatitis, Asthma and Allergic Rhinitis Using a Nation-wide Database, KNHANES VII

Lee

Koo

Han

et al. 2022

Allergy Asthma Immunol Res

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Purpose This study investigated mental health status and quality of life in allergic disease patients compared with non-allergic controls. Methods This study used nationwide, population-based, cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2016 to 2018. The propensity matching score was used to balance age and sex distributions between the allergic disease groups and corresponding controls. Atopic dermatitis (n = 446) and asthma (n = 483) groups were compared with controls in a 1:10 ratio, and the allergic rhinitis (n = 2,357) group was compared with controls in a 1:2 ratio. Multiple logistic regression analyses were used to evaluate the odds ratios (ORs) for mental health status and health-related quality of life (HRQoL) based on the presence of allergic diseases. Results The ORs for severe psychological stress, psychological consultation and diagnosis of depression were more significantly increased in the asthma (OR, 1.41, 1.83, and 2.1, respectively) and allergic rhinitis groups (OR, 1.35, 1.48, and 1.83, respectively) compared with non-allergic controls after adjustment for confounding factors. The rate of severe problems in mobility was more significantly increased in the asthma group compared to controls. Conclusions The results show that efforts should be made to manage psychological problems and improve HRQoL in patients with atopic dermatitis, asthma and allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Analysis of Quality of Life and Mental Health in Patients With Atopic Dermatitis, Asthma and Allergic Rhinitis Using a Nation-wide Database, KNHANES VII

Lee

Koo

Han

et al. 2022

Allergy Asthma Immunol Res

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“…However, many treatment options for CP can also improve NP ( Lavery et al., 2016 ; Table 3 ). There are very few SD intervention trials in patients with skin disorders ( Bawany et al., 2020 ). Treatment of the skin disorder itself with biologic (i.e., dupilumab for AD, and adalimumab or etanercept for psoriasis) or topical agents can have beneficial effects on both NP and SD ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Melatonin is an established treatment for delayed sleep phase disorder. Evidence for its effectiveness in insomnia is mixed ( Bawany et al., 2020 ). In a small, well-designed, crossover trial in atopic children, melatonin (3 mg at bedtime) significantly reduced sleep-onset latency compared with placebo ( Chang et al., 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients

Podder

Mondal²,

Kroumpouzos

2021

International Journal of Women's Dermatology

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Nocturnal pruritus (NP) is a relatively common reason for dermatologic consultation. Its pathophysiology is partially understood. Skin conditions such as atopic dermatitis, psoriasis, urticaria, and prurigo nodularis are well-described causes of NP. The most distressing sequela of NP is sleep deficit, which can lead to physical and mental disturbances (e.g., daytime somnolence and fatigue) and negative emotional states that profoundly affect quality of life. However, this aspect of NP is often overlooked by dermatologists. It is essential to assess sleep quality in such patients and adopt appropriate measures to arrest the problem at an early stage. We conducted an evidence-based literature review to highlight the pathogenetic mechanisms of NP, identify dermatologic etiologies, and explore methods that have been used to assess the quality of sleep. Furthermore, we performed a systematic review of studies on sleep disturbance relevant to NP in patients with dermatologic conditions. Finally, we discuss the evidence on treatment options for NP and indicate therapies that may target both NP and sleep disturbance.

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“…Atopic disorders are associated with mental health-related diseases such as depression, anxiety, attention deficit and hyperactivity disorder, and sleep disorder, which are suggested to have a bidirectional association with migraine. 34 35 36 37 38 39 40 41 42 Although the mechanism of these associations needs to be clarified, it can be explained by imbalance of the dopaminergic system and serotonin neurotransmitters, ovarian hormone fluctuation, altered autonomic regulation, and somatization. 42 43 A recent large genome-wide study has shown that migraine has a genetic correlation with psychiatric disorders, which suggests a common genetic basis or shared pathways between the 2.…”

Section: Discussionmentioning

confidence: 99%

Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

Han

Lee

Yook

et al. 2023

Allergy Asthma Immunol Res

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Purpose Migraine is a relatively common neurologic disorder. A possible link between atopic disorders and migraine has been suggested. This study investigated atopic disorders and their risks of migraine in the Korean population. Methods From the Korean National Health Insurance Service database, patients aged ≥ 20 years who underwent health screening between January and December of 2009 were enrolled. To evaluate the risk of migraine, Cox proportional hazards regression analyses were performed. Results In multivariable analysis, the atopic dermatitis group (adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.23–1.33), asthma group (aHR, 1.32; 95% CI, 1.30–1.34) and allergic rhinitis group (aHR, 1.45; 95% CI, 1.44–1.46) had significantly increased risks of migraine compared to their respective control groups ( P < 0.001). The patients with 1 (aHR, 1.43; 95% CI, 1.42–1.44), 2 (aHR, 1.50; 95% CI, 1.47–1.53), and 3 (aHR, 1.64; 95% CI, 1.43–1.88) atopic disorders had significantly increased risks of migraine compared to the control group ( P < 0.001). Conclusions Our results demonstrate that patients with atopic disorders may have increased risk of migraine and that the larger the number of concomitant atopic disorders, the higher the risk of migraine.

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Sleep Disturbances and Atopic Dermatitis: Relationships, Methods for Assessment, and Therapies

Cited by 51 publications

References 188 publications

Analysis of Quality of Life and Mental Health in Patients With Atopic Dermatitis, Asthma and Allergic Rhinitis Using a Nation-wide Database, KNHANES VII

Analysis of Quality of Life and Mental Health in Patients With Atopic Dermatitis, Asthma and Allergic Rhinitis Using a Nation-wide Database, KNHANES VII

Nocturnal pruritus and sleep disturbance associated with dermatologic disorders in adult patients

Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

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