Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

Abstract

Purpose Migraine is a relatively common neurologic disorder. A possible link between atopic disorders and migraine has been suggested. This study investigated atopic disorders and their risks of migraine in the Korean population. Methods From the Korean National Health Insurance Service database, patients aged ≥ 20 years who underwent health screening between January and December of 2009 were enrolled. To evaluate the risk of migraine, Cox proportional hazards regression analyses were performed. Results In multivariable analysis, the atopic dermatitis group (adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.23–1.33), asthma group (aHR, 1.32; 95% CI, 1.30–1.34) and allergic rhinitis group (aHR, 1.45; 95% CI, 1.44–1.46) had significantly increased risks of migraine compared to their respective control groups ( P < 0.001). The patients with 1 (aHR, 1.43; 95% CI, 1.42–1.44), 2 (aHR, 1.50; 95% CI, 1.47–1.53), and 3 (aHR, 1.64; 95% CI, 1.43–1.88) atopic disorders had significantly increased risks of migraine compared to the control group ( P < 0.001). Conclusions Our results demonstrate that patients with atopic disorders may have increased risk of migraine and that the larger the number of concomitant atopic disorders, the higher the risk of migraine.

A two‐sample bidirectional Mendelian randomization study revealed atopic dermatitis is associated with an increased risk of migraine

“…Consistent with the previous study, AD is positively associated with migraine in the population-based cohort study and adults with AD were 89% more likely to have a diagnosis of migraine. 1,5 Our novel findings further enhance our understanding of these associations and suggest causal links attributable to genetic factors; however, the potential sources of bias or confounding related to MR should be also considered. We discovered an increased risk of migraine among patients with AD.…”

Migraine, Allergy, and Histamine: Is There a Link?

“…As shown in Table 1, most studies reported that allergic/atopic disorders (including allergic rhinitis and atopic dermatitis), asthma, and migraine are reciprocally significantly associated [17][18][19][20][21][22][23][24][25][26][27]. The overlap between allergic disorders without asthma [37][38][39] and atopic dermatitis/eczema [40][41][42][43] with migraine is also consolidated.…”