Sleep Disturbance Worsens Lower Urinary Tract Symptoms: The Nagahama Study

Fukunaga, Arinobu; Kawaguchi, Takahisa; Funada, Satoshi; Yoshino, Takayuki; Tabara, Yasuharu; Matsuda, Fumihiko; Yoshimura, Koji; Ogawa, Osamu; Negoro, Hiromitsu

doi:10.1097/ju.0000000000000212

Cited by 25 publications

(44 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As pointed out by Blanker et al, the lack of frequency‐volume charts, resulting in a substantial misclassification of nocturia should be considered an important limitation, considering that we have no data on urine amount, overall/overnight urine production, or nocturnal bladder capacity. However, our study is in line with other reports evaluating nocturia episodes using the change of IPSS 7 question . As well, we do not have data on fluctuation of nocturia over time or on de novo nocturia after TURP.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Metabolic syndrome and smoking are associated with persistence of nocturia after transurethral resection of the prostate

Nunzio

Tema

Lombardo

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aims The aim of our study was to evaluate the relationship between smoking, metabolic syndrome (MetS) and persistence of nocturia in patients with moderate/severe nocturia (nocturia episodes ≥2), lower urinary tract symptoms (LUTSs), and benign prostatic enlargement (BPE) undergoing transurethral resection of the prostate (TURP). Methods From 2015 onward, a consecutive series of patients with moderate/severe nocturia (nocturia episodes ≥2), LUTS, and BPE undergoing TURP were prospectively enrolled. Medical history, physical examination, and smoking status were recorded. MetS was defined according to Adult Treatment Panel III. Moderate/severe persistent nocturia after TURP was defined as nocturia episodes ≥2. Binary logistic regression analysis was used to evaluate the risk of persisting nocturia. Results One hundred two patients were enrolled with a median age of 70 years (interquartile range: 65/73). After TURP, moderate/severe nocturia was reported in 43 of 102 (42%) of the patients. Overall 40 of 102 (39%) patients presented a MetS, and out of them, 23 of 40 (58%) presented a moderate/severe persistent nocturia after TURP ( P = .001). Overall 62 of 102 (61%) patients were smokers, and out of them, 32 of 62 (52%) presented moderate/severe persistent nocturia after TURP ( P = .034). On multivariate analysis, prostate volume, MetS, and smoking were independent risk factors for moderate/severe persistent nocturia after TURP. Conclusion In our single‐center study, MetS and smoking increased the risk of moderate/severe persistent nocturia after TURP in patients with LUTS‐BPE. Although these results should be confirmed, and the pathophysiology is yet to be completely understood, counseling smokers and MetS patients about the risk of postoperative persistent nocturia is warranted.

show abstract

Section: Discussionsupporting

confidence: 88%

“…However, our study is in line with other reports evaluating nocturia episodes using the change of IPSS 7 question. 32,33 As well, we do not have data on fluctuation of nocturia over time or on de novo nocturia after TURP.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and smoking are associated with persistence of nocturia after transurethral resection of the prostate

Nunzio

Tema

Lombardo

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…However, a recent large scale study in Japan demonstrated that sleep disturbance may worsen LUTS over the long term. 26 They speculated that imbalances in steroid hormone activity or sympathetic nervous system and an altered circadian rhythm may contribute to LUTS exacerbation. Our study also supports the impact of sleep disturbance on LUTS.…”

Section: Discussionmentioning

confidence: 99%

“…A causal relationship between sleep disturbance and OAB remains unknown. However, a recent large scale study in Japan demonstrated that sleep disturbance may worsen LUTS over the long term 26 . They speculated that imbalances in steroid hormone activity or sympathetic nervous system and an altered circadian rhythm may contribute to LUTS exacerbation.…”

Section: Discussionmentioning

confidence: 99%

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Okamoto

Andô

Jung

et al. 2020

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aims To investigate the longitudinal association of microalbuminuria with overactive bladder (OAB). Methods This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Urine ACR was defined as high if ≥9.3 mg/gCr. Differences in OABSS between 2015 and 2019 were evaluated as ∆OABSS. Participants were divided into two groups according to ΔOABSS: high (ΔOABSS > 1) and control (≤1). We used baseline data acquired in 2015, such as urine ACR, the Pittsburgh Sleep Quality Index (PSQI), and arterial stiffness expressed by brachial‐ankle pulse wave velocity (baPWV). Predictive factors of a ΔOABSS > 1 were assessed by multivariable logistic regression analysis. Results This study included 332 women and 229 men. Of those, 86 (34 males and 52 females) were classified into the ΔOABSS > 1 group. There were significant group differences in age, renal function, and hemoglobin A1c. Participants in the ΔOABSS > 1 had a higher prevalence of PSQI > 5, baPWV ≥ 1400 seconds/cm, and urine ACR ≥ 9.3 mg/gCr (49% vs 20%, P = .001) than those in the control group. Multivariable analysis revealed that PSQI > 5 (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.15‐4.60; P = .002) and urine ACR ≥ 9.3 mg/gCr (OR, 1.93; 95% CI, 1.15‐3.23; P = .013) were independent risk factors for ΔOABSS > 1. Conclusions Microalbuminuria may be an independent risk indicator for OAB symptom exacerbation.

show abstract

“…Lower urinary tract symptoms (LUTS) are among the most common urologic conditions in the older population . As the incidence of LUTS and frailty increases with age, the concept of frailty has been recognized as a key factor in older individuals with LUTS . However, only a few studies have evaluated the influence of frailty on LUTS .…”

Section: Introductionmentioning

confidence: 99%

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Sato

Imai

Matsumoto

et al. 2019

LUTS

View full text Add to dashboard Cite

Objectives: To evaluate the relationship between frailty and lower urinary tract symptoms (LUTS), the association of frailty and LUTS remains unclear. Methods: This cross-sectional study investigated LUTS and frailty in 710 individuals (249 men and 461 women, aged ≥60 years) who participated in the Iwaki Health Promotion Project between 2014 and 2015 in Hirosaki, Japan. Parameters of frailty were compared for individuals with mild and moderate to severe symptoms of LUTS. The International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) were used to evaluate LUTS. Frailty was evaluated by the frailty phenotype (FP), modified frailty index (mFI), and frailty discriminant score (FDS). The influence of frailty on LUTS was investigated by multivariate logistic regression analyses.Results: Frailty parameters of age, renal function, and lower physical activity were significantly associated with severity of IPSS and OABSS. FP and mFI were significantly associated with severity of OABSS and IPSS, respectively. The FDS was significantly associated with severity of IPSS and OABSS. FP, mFI, and FDS were significantly associated with severity of nocturia. Multivariate logistic regression analyses revealed that FDS was independently associated with the severity of IPSS, OABSS, and nocturia, whereas FP and mFI were significantly associated with the severity of nocturia alone.Conclusions: Individuals with LUTS are potentially frailer than those without LUTS.Although the influence of frailty on LUTS is different depending on the measurement tool, attention for frailty is necessary for subjects with LUTS.

show abstract

Sleep Disturbance Worsens Lower Urinary Tract Symptoms: The Nagahama Study

Cited by 25 publications

References 0 publications

Metabolic syndrome and smoking are associated with persistence of nocturia after transurethral resection of the prostate

Metabolic syndrome and smoking are associated with persistence of nocturia after transurethral resection of the prostate

The impact of microalbuminuria on overactive bladders: Results from a community‐based four‐year longitudinal study in Japan

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Contact Info

Product

Resources

About