Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition

Vernia, Filippo; Ruscio, Mirko Di; Ciccone, Anna Maria; Frieri, Giuseppe; Stefanelli, Gianpiero; Latella, Giovanni

doi:10.7150/ijms.45512

Cited by 40 publications

(24 citation statements)

References 162 publications

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“…It is known that the timing of food intake, especially stimulants like coffee and spices, is related to sleep quality. 91,107,108 We also found a significant inverse association between hs-CRP and TGFβ with sleep quality. This finding was in accordance with the studies examining the association between inflammatory markers and sleep health.…”

Section: Discussionmentioning

confidence: 57%

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Association of plant‐based diet index with inflammatory markers and sleep quality in overweight and obese female adults: A cross‐sectional study

et al. 2021

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Background Inflammation and sleep disturbances increase the risk of multiple diseases, including cardiovascular disease, type 2 diabetes and dementia. Since diet plays a significant role in inflammatory responses and sleep quality, this study aimed to investigate the association of a plant‐based diet index (PDI) with sleep quality and inflammatory markers in overweight and obese women. Methods 390 overweight and obese women aged 18‐48 years participated in this cross‐sectional study. A validated food frequency questionnaire (FFQ) was used to create an overall PDI, healthful plant‐based diet index (hPDI) and unhealthful plant‐based diet index (uPDI). Sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI). Higher scores on the PSQI were indicative of poor sleep. Anthropometric measurements and serum concentrations of high‐sensitivity C‐reactive protein (hs‐CRP), interleukin 1 beta (IL‐1β) and transforming growth factor‐beta (TGF‐β) were evaluated. Linear regression models were used to determine the association between exposure and outcomes. Results After taking potential confounders into account, we found a significant inverse association between adherence to hPDI and hs‐CRP (β = −0.14, 95% confidence interval [CI]: −0.22,0.06, P = .001) and a significant positive association between uPDI and hs‐CRP (β = 0.13, 95% CI: 0.05,0.21, P = .001). Overall, PDI was significantly associated with TGF‐β (β = 2.04, 95% CI: 0.54,3.55, P = .008). No association was detected between PDI indices and IL‐1β. Higher adherence to uPDI was significantly associated with higher PSQI score (lower sleep quality) (β= 0.20, 95% CI:0.007,0.40, P = .04). A significant positive association was found between TGF‐β (β = 0.05, 95% CI:0.005,0.10, P = .03) and hs‐CRP (β = 0.32, 95% CI:0.02,0.62, P = .03) with PSQI. Conclusion Our findings indicated a significant association between adherence to a plant‐based diet with inflammation and sleep quality in obese and overweight females. What is already known about this topic? Sleep is an essential part of life, and sleep quality has a significant impact on individual well‐being and performance. There is a bidirectional relationship between disturbed sleep and elevated levels of inflammatory markers. Diet plays a major part in sleep quality and its related health consequences. Plant‐based diets are associated with lower risk of chronic diseases such as coronary artery disease (CAD), type 2 diabetes, obesity and reduced level of inflammation. What does this article add? Adherence to a healthful plant‐based diet is associated with lower level of hs‐CRP, while adherence to an unhealthful plant‐based diet is associated with higher concentrations of hs‐CRP. Adherence to an unhealthful plant‐based diet is associated with lower sleep quality.

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Section: Discussionmentioning

confidence: 57%

“…Moreover, we did not have any information about the meal timing of our participants. It is known that the timing of food intake, especially stimulants like coffee and spices, is related to sleep quality 91,107,108 …”

Section: Discussionmentioning

confidence: 99%

Association of plant‐based diet index with inflammatory markers and sleep quality in overweight and obese female adults: A cross‐sectional study

et al. 2021

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“…A prospective cohort study found that women with poor sleep quality were prone to intake more and had a lower-quality diet [37]. Some reviews pointed out that sleep influenced dietary choices; people who slept less were more likely to prefer fats, eat fewer vegetables, and choose irregular eating patterns [38,39]. The proposed mechanisms by which sleep may stimulate food intake were by the upregulation of the activity of the central nervous hypocretin system and changes in key appetite hormones [40].…”

Section: Discussionmentioning

confidence: 99%

Higher HEI-2015 Scores Are Associated with Lower Risk of Sleep Disorder: Results from a Nationally Representative Survey of United States Adults

Deng

Nie

et al. 2022

Nutrients

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Whether there is an association between dietary quality and sleep disorder in American adults is unclear. We conducted this study to analyze whether dietary quality, using the Healthy Eating Index-2015 (HEI-2015) scores as the measure, was associated with self-reported sleep disorders. Data came from the National Health and Nutrition Examination Survey (2005–2014). Step-weighted logistic regression models were performed to explore the relationships between the HEI-2015 scores and sleep disorder. Weighted quantile sum regression model was used to identify the HEI-2015 components most strongly associated with sleep disorders. According to quartiles, HEI scores were categorized into inadequate (<25%), average (25–75%), and optimal (>75%). Compared to inadequate HEI status, average HEI status (OR: 0.961, 95%CI: 0.959–0.962) and optimal HEI status (OR: 0.913, 95% CI: 0.912–0.915) were associated with reduced risk of sleep disorder after multivariable adjustments. Greens and beans, added sugars, saturated fats, total vegetables and total protein foods were the top five important components for sleep disorders. Our results suggest that there is a statistically significant association between better dietary quality and reduced risk of sleep disorder among United States adults.

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“…Sleep disorders affect many individuals worldwide and is increasing alarmingly ( 1 ). Both short and excessive sleep duration may contribute to a lower quality of life and unfavorable health outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…However, the impact of sleep quality on gastrointestinal disorders is often underappreciated in clinical practice. Over the past years, emerging studies have indicated that unhealthy sleep patterns can contribute significantly to the pathogenesis of gastroesophageal and small intestinal disorders (1,(3)(4)(5). People with frequent sleep disturbance are more likely to experience peptic ulcer disease, gastroesophageal reflux disease, and irritable bowel syndrome because of the disruption of circadian rhythms and immune systems (4).…”

Section: Introductionmentioning

confidence: 99%

Association of sleep duration with chronic constipation among adult men and women: Findings from the National Health and Nutrition Examination Survey (2005–2010)

Yang

Guo

et al. 2022

Front. Neurol.

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BackgroundPrevious studies suggested that unhealthy sleep patterns were closely associated with gastrointestinal diseases, but the impact of unhealthy sleep duration on chronic constipation has not been well studied until now. In this study, we aim to explore the association between sleep duration and constipation among males and females.MethodsWe utilized the US National Health and Nutrition Examination Surveys data from 2005 to 2010, and adults (≥20 years old) who completed the sleep and bowel health questionnaires were enrolled in this observational study. Sleep duration was categorized into four groups: very short sleep (<5 h/night), short sleep (5–6 h/night), normal sleep (7–8 h/night), and long sleep (≥9 h/night). Chronic constipation was defined as Bristol Stool Scale Type 1(separate hard lumps, like nuts) or Type 2(sausage-like but lumpy). Controlling demographic, lifestyle, and dietary factors, the logistic regression model in Generalized Linear Model (GLM) function was used to estimate the correlation of sleep duration with constipation among men and women.ResultsOf the 11,785 individuals (51.2% males and 48.8% females), 4.3% of men and 10.2% of women had constipation, respectively. More than half of patients with constipation did not adopt the recommended sleep duration. Compared with normal individuals, male participants with constipation had a higher proportion of shorter sleep duration (41.0 vs. 32.3% in the short sleep group and 6.3 vs. 4.7% in the very short sleep group), and female individuals with constipation had a higher proportion of long sleep duration (12.7 vs. 8.2%). After covariates adjustment, men with short sleep duration (5–6 h/night) correlated with increased odds for constipation (OR:1.54, 95%CI:1.05–2.25), and women with long sleep duration (≥9 h/night) linked to the higher constipation risk (OR:1.58, 95%CI:1.10–2.29). Excessive sleep duration in males or insufficient sleep duration in females was neither linked to increased nor decreased constipation risk.ConclusionsIn this observational study of a nationally representative sample of adults, we demonstrate a differential impact of unhealthy sleep duration on constipation among men and women. Short sleep duration poses a higher risk of constipation in men, and excessive sleep duration correlates with higher constipation risk in women.

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Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition

Cited by 40 publications

References 162 publications

Association of plant‐based diet index with inflammatory markers and sleep quality in overweight and obese female adults: A cross‐sectional study

Association of plant‐based diet index with inflammatory markers and sleep quality in overweight and obese female adults: A cross‐sectional study

Higher HEI-2015 Scores Are Associated with Lower Risk of Sleep Disorder: Results from a Nationally Representative Survey of United States Adults

Association of sleep duration with chronic constipation among adult men and women: Findings from the National Health and Nutrition Examination Survey (2005–2010)

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