Sleep disorders in patients with cervical dystonia

Samushiya, M A; Ragimova, A.; Ivolgin, A. F.; Avseitseva, T.Y.; Смоленцева, И. Г.; Ivannikova, E I

doi:10.17116/jnevro202012012125

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…[27] highlight the need for a systematic screening of fatigue and excessive daytime sleepiness in daily practice and the need to treat possible factors that contribute to a worsening of patients' QoL such as depression and pain. Indeed, pain as a stress factor, acting in conjunction with other factors, contributes to increasing the likelihood of depression [39] that is the main predictor of worsened QoL in CD patients [21]. The prevalence of impaired sleep quality in patients with cervical dystonia is between 40% and 70% [41].…”

Section: Discussionmentioning

confidence: 99%

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The Impact of Non-Motor Symptoms on Quality of Life in Cervical Dystonia

Maione

Formica

Quartarone

et al. 2023

JCM

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Cervical dystonia (CD) is characterized by cranial muscle overactivity leading to abnormal intermittent or continuous posturing of the head. Nowadays, the treatment of patients suffering from this condition focuses principally on the motor component of the disorder, certainly the invaliding part; however, it leaves out the non-motor one that has a similarly invalidated effect on the quality of the subject’s life. This review was conducted on studies investigating the impact of non-motor symptoms on levels of quality of life. We searched on the PubMed, EMBASE and Web of Science databases and screening references of included studies and review articles for additional citations. From an initial 150 publications, we included only five studies that met the search criteria. The results showed that anxiety, depression, pain and sleep quality have a great influence on patients’ health and on the outcome of the disease. Future studies should focus more on investigating the non-motor components of CD as an integral part of the clinical management of dystonic patients in order to improve their well-being.

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Section: Discussionmentioning

confidence: 99%

“…In contrast, other authors have reported NMSs in CD in association with major motor disability [19]. It has also been observed that NMSs, in particular neuropsychiatric symptoms and pain, are more important predictors of QoL than the severity of dystonia itself [20][21][22].…”

Section: Introductionmentioning

confidence: 95%

The Impact of Non-Motor Symptoms on Quality of Life in Cervical Dystonia

Maione

Formica

Quartarone

et al. 2023

JCM

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“…Those that have have demonstrated changes in participants with cranio‐cervical dystonia. Changes reported include a decrease in sleep efficiency (SE), total sleep time (TST) and percentage rapid eye movement (REM) sleep, and an increase in sleep latency (SL), wakefulness after sleep onset and REM SL, compared to controls (Antelmi et al., 2017 ; Lobbezoo et al., 1996 ; Ray et al., 2021 ; Samushiya et al., 2020 ; Sforza et al., 1991 ; Silvestri et al., 1990 ). Sleep fragmentation and increased REM SL have also been observed in GCH1 mutation‐positive dopa‐responsive dystonia (Brüggemann et al., 2014 ), as well as higher numbers of sleep spindles observed in primary and secondary forms of dystonia (Fish et al., 1990 ).…”

Section: Introductionmentioning

confidence: 99%

Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study

Bailey,

Wadon,

Komarzynski

et al. 2023

Brain and Behavior

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BackgroundSleep disturbance is an increasingly recognized non‐motor trait in dystonia, with varying findings reported to date. Here, we examine sleep in a UK Biobank derived dystonia cohort using subjective self‐reported sleep symptoms and objective accelerometer‐derived sleep measures, with comparison to a control population.MethodsA total of 241 dystonia cases were compared to 964 matched controls in analysis of self‐reported sleep symptoms and changes in sleep architecture using wrist‐worn triaxial accelerometers.ResultsDystonia participants had poorer self‐reported sleep patterns compared to controls. Accelerometery measurements demonstrated later sleep times, reduced time in bed, and shifts in circadian rhythm. No association was observed with pain, and only limited relationships with psychiatric symptoms.DiscussionThis study demonstrates the utility of accelerometers in longer term evaluation of sleep in dystonia, for measurement of disturbance and response to treatment. Compared to controls, altered sleep and circadian rhythm were more common in dystonia patients which may contribute to the clinical phenotype.

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“…Associated non-motor symptoms are becoming increasingly recognised, with estimates between 33 to 70% of individuals experiencing sleep impairment with an associated reduction in quality of life [2,3]. To date, few studies have addressed sleep in AOIFCD using 'gold-standard' polysomnography (PSG), with those that have demonstrated reduced sleep efficiency, together with increased sleep latency, wake after sleep onset (WASO), REM sleep latency and percentage of time spent in rapid eye movement (REM) sleep, in comparison to controls [4][5][6]. However, PSG can be expensive and time consuming, with limitations in being able to extrapolate findings from single night recordings in an unfamiliar environment to the wider context of sleep.…”

Section: Introductionmentioning

confidence: 99%

Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia

Bailey

Matthews²,

Szewczyk-krolikowski

et al. 2022

J Neurol

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Background Up to 70% of individuals diagnosed with adult-onset idiopathic focal cervical dystonia (AOIFCD) report difficulties with sleep. Larger cohort studies using wrist-worn accelerometer devices have emerged as an alternative to smaller polysomnography studies, in order to evaluate sleep architecture. Methods To measure activity during the sleep/wake cycle, individuals wore a consumer-grade wrist device (Garmin vivosmart 4) continuously over 7 days on their non-dominant wrist, while completing a daily sleep diary and standardised sleep and non-motor questionnaires via a dedicated app. Sleep measures were derived from the captured raw triaxial acceleration and heart rate values using previously published validated algorithms. Results Data were collected from 50 individuals diagnosed with AOIFCD and 47 age- and sex-matched controls. Those with AOIFCD self-reported significantly higher levels of excessive daytime sleepiness (p = 0.04) and impaired sleep quality (p = 0.03), while accelerometer measurements found the AOIFCD cohort to have significantly longer total sleep times (p = 0.004) and time spent in NREM sleep (p = 0.009), compared to controls. Overall, there was limited agreement between wearable-derived sleep parameters, and self-reported sleep diary and visual analogue scale records. Discussion This study shows the potential feasibility of using consumer-grade wearable devices in estimating sleep measures at scale in dystonia cohorts. Those diagnosed with AOIFCD were observed to have altered sleep architecture, notably longer total sleep time and NREM sleep, compared to controls. These findings suggest that previously reported disruptions to brainstem circuitry and serotonin neurotransmission may contribute to both motor and sleep pathophysiology.

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Sleep disorders in patients with cervical dystonia

Cited by 5 publications

References 11 publications

The Impact of Non-Motor Symptoms on Quality of Life in Cervical Dystonia

The Impact of Non-Motor Symptoms on Quality of Life in Cervical Dystonia

Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study

Use of remote monitoring and integrated platform for the evaluation of sleep quality in adult-onset idiopathic cervical dystonia

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