Sleep deprivation as a predictor of response to light therapy in major depression

Fritzsche, M; Heller, Roy L.; Hill, Holger; Kick, Hermes Andreas

doi:10.1016/s0165-0327(00)00154-3

Cited by 43 publications

(23 citation statements)

References 44 publications

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“…A 35% improvement in depression as compared to dim light control treatment was observed at the end of a week. This benefit has recently been replicated by Bloching et al [2000] and Fritzsche et al [2001]. We examined whether this antidepressant benefit could be obtained in an outpatient setting.…”

Section: Introductionmentioning

confidence: 59%

Bright light augments antidepressant effects of medication and wake therapy

2002

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Inpatient studies have suggested that bright light therapy can be used to sustain the antidepressant effects of wake therapy (sleep deprivation). In an outpatient trial, a half night of home wake treatment was followed by 1 week of light treatment. All subjects had Major Depressive Disorders according to DSM-IV criteria and were receiving concomitant antidepressant medication. Subjects were randomly assigned to receive either 10,000 lux bright white light for 30 min between 6 and 9 AM or dim red (placebo) light at a comparable time. Seven subjects completed treatment with bright white light and six completed treatment with placebo. On the Hamilton Depression Rating Scale (HDRS17, SIGH-SAD-SR version), the group receiving bright light improved 27% in 1 week (P=0.002). The group receiving placebo did not improve, except for one outlier. The benefit of bright light was significant compared to placebo with removal of the outlier (P<0.025).

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Section: Introductionmentioning

confidence: 59%

Bright light augments antidepressant effects of medication and wake therapy

2002

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“…Diagnostic and Statistical Manual of Mental Disorders -III Revision and -IV (DSM-III-R and -IV) were prevalent diagnostic questionnaires in selected articles. Twenty-one studies used Hamilton Depression Rating Scale (HDRS) for scoring mood states [9], [11], [15], [16], [20][21][22][23], [30], [32], [34][35][36][37][38][39][40][41][42][43][44]. The other studies used scales such Geriatric Depression Scale, Major Depression Inventory and The International Classification of Diseases.…”

Section: Resultsmentioning

confidence: 99%

“…According to the PEDro scale, the qualities of selected studies were generally high ranging from 7/11 to 11/11. Deltito et al, [16] 1M/16F 36 ± NR MDD, BD, UBD DSM-III-R 10 Fritzsche et al, [37] 14M/26F 47.0 ± 11.0 MDD, SAD DSM-IV 10 Goel et al, [40] 8M/24F 43.1 ± 12.0 MDD DSM-IV 9 Holsboer-Trachsler et al, [42] 22M/22F 52.0 ± 9.0 MDD, BD, UBD, DD DSM-III-R 10 Kripke et al, [9] 11M/1F Mean age not reported MDD, BD RDC 9 Kripke et al, [22] 50M/1F 48.0 ± NR MDD, BD DSM-III 9…”

Section: Resultsmentioning

confidence: 99%

“…However, studies that combined antidepressant therapy with light therapy found greater improvement than with light therapy alone [11], [15], [24], [35][36][37], [41], [42], [44] suggestive of synergistic effects. On the other hand, the use of antidepressant medication with light therapy also showed no mood effects [30,32].…”

Section: Antidepressant Medication -Resistance To Medicationmentioning

confidence: 99%

“…They noted that this response was superior when compared with the use of antidepressant drugs alone, which produced only a relative benefit of 8-11%. Subsequently, Fritzsche et al [37] showed that people who responded to sleep deprivation also responded to light therapy (regardless of intensity and colour) whereas, those who did not respond to sleep deprivation also did not respond to light therapy. This linked response is of interest.…”

Section: Sleep Deprivationmentioning

confidence: 99%

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A systematic review of light therapy on mood scores in major depressive disorder: light specification, dose, timing and delivery

Alotaibi

Halaki

Chow

2015

IJBAS

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Background: Depression is associated with prolonged disability, mortality, and morbidity. Ninety percent of patients with Major depressive disorder (MDD) have sleep problems. Light therapy has been shown to be effective in treating sleep disorders and MDD. This review aims to assess the characteristics (colour, intensity), exposure dose (duration and timing) and the mode of delivery (light boxes, visor etc) of light in reducing depression, measured by mood scores, in MDD. Method: a systematic literature search was performed on 6 major databases. The Physiotherapy Evidence Database (PEDro) Scale was applied to assess study quality. Result: Twenty-four articles satisfied the inclusion criteria. Effective light intensities varied from 176 -10,000 lux. Effective modes of delivery included light box, table lamp, visor and light emitting diode (LED) glasses. Effective light colours included white, green, and blue with the white colour being the most commonly used. The duration of light treatment ranged from 30 min to 2 h, and evening light generally improved mood. Conclusion: Light therapy, with exposure durations in the range of 30 min to 2 h per day, intensity range of 176 to 10,000 lux, in any of blue, green, or white light colour and exposure during morning mostly demonstrated a positive change in mood effects. Factors other than the light properties, such as anti-depressant medication use, depression episodes and severity, natural light exposure and sleep deprivation may confound the effects of light therapy.

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Light therapy for non-seasonal depression

Tuunainen

Kripke

Endo³

2004

Cochrane Database of Systematic Reviews

178

110

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For patients suffering from non-seasonal depression, bright light therapy offers modest though promising antidepressive efficacy, especially when administered during the first week of treatment, in the morning, and as an adjunctive treatment to sleep deprivation responders. Hypomania as a potential adverse effect needs to be considered. Due to limited data and heterogeneity of studies these results need to be interpreted with caution.

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Sleep deprivation as a predictor of response to light therapy in major depression

Cited by 43 publications

References 44 publications

Bright light augments antidepressant effects of medication and wake therapy

Bright light augments antidepressant effects of medication and wake therapy

A systematic review of light therapy on mood scores in major depressive disorder: light specification, dose, timing and delivery

Light therapy for non-seasonal depression

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