Light therapy for non-seasonal depression

Tuunainen, Arja; Kripke, Daniel F.; Endo, Tokiko

doi:10.1002/14651858.cd004050.pub2

Cited by 178 publications

(120 citation statements)

References 68 publications

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“…Controlled trials of light therapy for non-seasonal depression have been reviewed (Kripke, 1998) and are the focus of two recent meta-analyses (Tuunainen et al 2004 ;Golden et al in press). Cautious in their recommendations (' light therapy offers modest though promising antidepressive efficacy, especially when administered during the first week of treatment, in the morning, and as an adjunctive treatment to sleep deprivation responders' (Tuunainen et al 2004, p. 1), these overviews emphasize the need for further studies.…”

mentioning

confidence: 99%

Chronotherapeutics (light and wake therapy) in affective disorders

Wirz‐Justice¹,

Benedetti²,

Berger³

et al. 2005

Psychol. Med.

222

100

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The Committee on Chronotherapeutics was recently formed by the International Society for Affective Disorders (ISAD), which has asked us to provide a consensus review of chronotherapeutics (light and wake therapy) in affective disorders. We consider these non-pharmaceutical, biologically based therapies to be potentially powerful adjuvants ready for clinical application. We also stress the need for additional studies, both in-patient and out-patient, to broaden the evidence base for indications and efficacy.

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mentioning

confidence: 99%

Chronotherapeutics (light and wake therapy) in affective disorders

Wirz‐Justice¹,

Benedetti²,

Berger³

et al. 2005

Psychol. Med.

222

100

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“…31,32 Furthermore, a Cochrane review of studies of BLT in non-seasonal affective disorder concluded that BLT may be effective in as little as 1 week. 33 Generally, BLT is well tolerated and well accepted by patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of effects of bright light therapy alone or combined with fluoxetine on severity of depression, circadian rhythms, mood disturbance, and sleep quality, in patients with non-seasonal depression

Ağargün¹,

Sayar²,

Bulut³

et al. 2013

CPT

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Purpose:To compare effects of bright light therapy (BLT) alone or combined with the selective serotonin reuptake inhibitor (SSRI) fluoxetine, on severity of depression, circadian rhythms, mood disturbance, and sleep quality, in patients with non-seasonal depression. Patients and methods: Drug-free patients who were administered 10,000 lux of BLT for 30 minutes for 7 days comprised the BLT group (n = 7), while patients who started fluoxetine as an add-on treatment day comprised the SSRI + BLT group (n = 8). The primary outcomes were severity of depression, measured using the Hamilton Depression Rating Scale (HAM-D) and the Beck Depression Inventory (BDI); chronotype, measured using the Morningness Eveningness Questionnaire (MEQ); mood disturbance, measured using the Profile of Mood States (POMS) survey; and sleep quality, measured using the Pittsburgh Sleep Quality Index (PSQI), before and after treatment in both groups. Results: All patients completed the study, and none reported obvious side effects. The mean onset age of depression was 26.1 years ± 5.3 years in the BLT group and 27 years ± 9.5 years in the SSRI + BLT group (P = 0.425). The number of past depressive episodes was 1.29 ± 0.76 in the BLT group, and 1.5 ± 0.8 in the SSRI + BLT group (P = 0.427). The difference between pre-and posttreatment scores revealed no significant difference between groups for the HAM-D scale, BDI, MEQ, POMS survey, and the PSQI. Conclusion: This study suggests that BLT is effective with respect to the severity of depression, circadian rhythms, mood disturbance, and sleep quality, in non-seasonal depression. However, there was no evidence in favor of adjunctive fluoxetine with BLT in the treatment of non-seasonal depression, for any of the rating scales used in our study.

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“…In a review of nonseasonal light therapy trials, the frequency of these symptoms was not shown to be significantly different from the control groups. 32 In terms of ocular safety, a study of long-term exposure to light treatment did not reveal ophthalmological problems in participants. 33,34 Overall, light therapy is considered well tolerated and safe, and presents with a convincing risk-to-benefit ratio.…”

Section: Light As a Therapeutic Toolmentioning

confidence: 96%

An insight into light as a chronobiological therapy in affective disorders

Walsh¹,

Atkinson²,

Corlett³

et al. 2014

CPT

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Abstract:The field of chronobiology has vastly expanded over the past few decades, bringing together research from the fields of circadian rhythms and sleep. The importance of the environmental day-night cycle on our health is becoming increasingly evident as we evolve into a 24-hour society. Reducing or changing sleep times against our natural instincts to rest at night has a detrimental impact on our well-being. The mammalian circadian clock, termed "the suprachiasmatic nucleus", is responsible for synchronizing our behavioral and physiological outputs to the environment. It utilizes light transcoded by specialized retinal photoreceptors as its cue to set internal rhythms to be in phase with the light-dark cycle. Misalignment of these outputs results in symptoms such as altered/disturbed sleep patterns, changes in mood, and physical and mental exhaustion -symptoms shared by many affective clinical disorders. Key links to circadian abnormalities have been found in a number of disorders, such as seasonal affective disorder, nonseasonal depression, and bipolar affective disorder. Furthermore, therapies developed through chronobiological research have been shown to be beneficial in the treatment of these conditions. In this article, we discuss the impact of circadian research on the management of affective disorders, giving evidence of how a misaligned circadian system may be a contributor to the symptoms of depression and how moderating circadian rhythms with light therapy benefits patients.

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Light therapy for non-seasonal depression

Cited by 178 publications

References 68 publications

Chronotherapeutics (light and wake therapy) in affective disorders

Chronotherapeutics (light and wake therapy) in affective disorders

Comparison of effects of bright light therapy alone or combined with fluoxetine on severity of depression, circadian rhythms, mood disturbance, and sleep quality, in patients with non-seasonal depression

An insight into light as a chronobiological therapy in affective disorders

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