Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice

Araujo, N.P.; Andersen, Mônica Levy; Abı́lio, Vanessa C.; Gomes, Daniel; Carvalho, Reinaldo de Amorim; Silva, Regina H.; Ribeiro, R. de A.; Tufik, Sérgio; Frussa‐Filho, Roberto

doi:10.1016/j.brainresbull.2006.01.006

Cited by 24 publications

(12 citation statements)

References 38 publications

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“…Motor behavior in the PMDAT could be suppressed due to exposure to aversive stimuli. However, even if basal motor behavior is inhibited by the aversive situation, the pattern of ETOH action on locomotion is similar to that found in locomotor activity tests free from suppressive effects of aversive stimuli (Cohen et al 1997;Araujo et al 2006). In addition, mice treated with reserpine and haloperidol (motor depressant drugs, Silva et al 2002b;Correia-Pinto et al, unpublished data) or amphetamine and cocaine (motor stimulant drugs, Silva et al 2002a;Niigaki et al, unpublished data) presented decreased or increased number of entries in the arms of PMDAT, respectively.…”

Section: Discussionmentioning

confidence: 56%

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

et al. 2007

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Section: Discussionmentioning

confidence: 56%

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

et al. 2007

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“…With evidence that MCH is generally neuronally inhibitory [31, 73], our results showing acute ethanol to reduce MCH-expressing neurons in the ZI suggests that local neural activity may be disinhibited, leading to an increase in locomotor activity and possibly intake of ethanol. This is supported by evidence showing that acute ethanol can enhance activity levels in animals [74, 75]. Thus, MCH neurons within the ZI, having distinct projection sites from the LH [76], may function to increase ethanol consumption by enhancing locomotor activity rather than reward-related behaviors.…”

Section: Discussionmentioning

confidence: 87%

Role of melanin-concentrating hormone in the control of ethanol consumption: Region-specific effects revealed by expression and injection studies

Morganstern

Chang

Chen

et al. 2010

Physiology & Behavior

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The peptide melanin-concentrating hormone (MCH), produced mainly by cells in the lateral hypothalamus (LH), perifornical area (PF) and zona incerta (ZI), is suggested to have a role in the consumption of rewarding substances, such as ethanol, sucrose and palatable food. However, there is limited information on the specific brain sites where MCH acts to stimulate intake of these rewarding substances and on the feedback effects that their consumption has on the expression of endogenous MCH. The current study investigated MCH in relation to ethanol consumption, in Sprague-Dawley rats. In Experiment 1, chronic consumption of ethanol (from 0.70 to 2.7 g/kg/ day) dose-dependently reduced MCH gene expression in the LH. In Experiments 2-4, the opposite effect was observed with acute oral ethanol, which stimulated MCH expression specifically in the LH but not the ZI. In Experiment 5, the effect of MCH injection in brain-cannulated rats on ethanol consumption was examined. Compared to saline, MCH injected in the paraventricular nucleus (PVN) and nucleus accumbens (NAc) selectively stimulated ethanol consumption without affecting food or water intake. In contrast, it reduced ethanol intake when administered into the LH, while having no effect in the ZI. These results demonstrate that voluntary, chronic consumption of ethanol leads to local negative feedback control of MCH expression in the LH. However, with a brief exposure, ethanol stimulates MCH-expressing neurons in this region, which through projections to the feeding-related PVN and reward-related NAc can promote further drinking behavior.

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“…Sleep deprivation was carried out for 72 h using the modified multiple platform method [19,20,21,22,23,24,25,26,27], which consists of placing 5 mice in a ventilated cage (38 × 31 × 17 cm; Tecniplast, Buguggiate, Italy) containing 14 circular platforms (3.5 cm in diameter) with water 1 cm below the upper surface. At the onset of each paradoxical sleep episode, the animal experiences a loss of muscle tonus and falls into the water, thus awakening.…”

Section: Methodsmentioning

confidence: 99%

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Maragno-Correa

Patti

Zanin

et al. 2013

Neuroimmunomodulation

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Objectives: Sleep deprivation is a growing public health hazard, yet it is still under-recognized. Sleep disorders and disruption of sleep patterns may compromise the immune function and adversely affect host resistance to infectious diseases. This is a particular risk in cancer patients, who report a high frequency of sleep disturbances. The present study investigated the effects of sleep deprivation on the development of Ehrlich ascitic tumors (EAT) in female BALB/c mice. Our study also evaluated whether EAT would induce alterations in sleep pattern. Spleen lymphocyte cell populations and mortality were also quantified. Methods: Female BALB/c mice were intraperitoneally inoculated with EAT cells. Immediately after the inoculation procedure, animals were sleep deprived for 72 h. Ten or 15 days after inoculation, the number of tumoral cells was quantified and the lymphocytic cell population in the spleen was characterized by flow cytometry. In addition, the effect of sleep deprivation on EAT-induced mortality was quantified and the influence of EAT on sleep patterns was determined. Results: Sleep deprivation did not potentiate EAT growth, but it significantly increased mortality. Additionally, both EAT and sleep deprivation decreased frequencies of splenic CD4+, CD8+ and CD19+ cells. With respect to sleep patterns, EAT significantly enhanced paradoxical sleep time. Conclusions: Although sleep deprivation did not potentiate EAT growth, it decreased the survival of female tumor-bearing mice.

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Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice

Cited by 24 publications

References 38 publications

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

Role of melanin-concentrating hormone in the control of ethanol consumption: Region-specific effects revealed by expression and injection studies

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

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