Sleep Apnea and the Risk of Chronic Kidney Disease: A Nationwide Population-Based Cohort Study

The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology

“…In a large and contemporary cohort of more than 3 million US veterans, a diagnosis of incident OSA was associated with higher mortality, coronary artery disease, stroke, and CKD along with faster decline of kidney function [17] . In another retrospective cohort study from Taiwan of >4,600 incident patients with sleep apnea, the investigators showed a 1.94-fold increase in the incidence of CKD, as well as a 2.2-fold increase in the incidence of ESRD [18] . Markou et al [19] measured AHI in patients with stable CKD (creatinine clearance <40 mL/min) and found that the severity of AHI correlates with urea concentration and creatinine clearance.…”

Effect of positive airway pressure on glomerular filtration rate in patients with sleep-disordered breathing: a meta-analysis

“…The impact of SDB on the development of CKD has been demonstrated by accumulating evidence [4,[18][19][20]. A retrospective cohort study including 4674 adult sleep apnea (SA) patients and 23,370 non-SA patients as the comparison group found that patients with SA experienced a 1.94-fold and 2.2-fold increase in the incidence of CKD and ESRD, respectively, after adjustment for sex, age, and comorbid medical conditions [18].…”

“…A retrospective cohort study including 4674 adult sleep apnea (SA) patients and 23,370 non-SA patients as the comparison group found that patients with SA experienced a 1.94-fold and 2.2-fold increase in the incidence of CKD and ESRD, respectively, after adjustment for sex, age, and comorbid medical conditions [18]. A crosssectional study that enrolled 40 severe OSA patients without diabetes or hypertension showed that the prevalence of CKD in severe OSA subjects was 18 %.…”

Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

“…Rates of reported sleep apnoea in this cohort were considerably lower than in previous reports, 116 which may reflect a broader problem of under-recognition and diagnosis of sleep apnoea in the general population. 87,89 While observational studies have linked OSA with chronic kidney disease (CKD), 117 whether OSA is an independent risk factor is unknown. To further clarify this issue, Chu et al 118 reviewed data from over 8500 newly diagnosed sleep apnoea patients and matched these with control subjects.…”