Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

Jee, Adelle S.; Corte, Tamera J.; Wort, Stephen J.; Eves, Neil D.; Wainwright, Claire; Piper, Amanda J.

doi:10.1111/resp.13080

Cited by 2 publications

(2 citation statements)

References 143 publications

(166 reference statements)

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“…The ATS-DLD-78-A questionnaire was used to obtain information on the subject’s symptoms of lung disease and their personal and family history of lung disease [ 8 ]. Disease was diagnosed by medical doctors and confirmed using the subject’s hospital and national health insurance records to rule out interstitial lung diseases caused by drugs, scleroderma, systemic lupus erythaematosus, rheumatoid arthritis, or any other autoimmune diseases [ 9 , 10 ].…”

Section: Methodsmentioning

confidence: 99%

Development of breath test for pneumoconiosis: a case-control study

et al. 2017

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BackgroundLipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of this study was to develop a breath test for pneumoconiosis.MethodsA case-control study was designed. Breath and ambient air were analysed by gas chromatography/mass spectrometry. After blank correction to prevent contamination from ambient air, we used canonical discriminant analysis (CDA) to assess the discrimination accuracy and principal component analysis (PCA) to generate a prediction score. The prediction accuracy was calculated and validated using the International Classification of Radiographs of the Pneumoconiosis criteria combined with an abnormal pulmonary function test as a reference standard. We generated a receiver operator characteristic (ROC) curve and calculated the area under the ROC curve (AUC) to estimate the screening accuracy of the breath test.ResultsWe enrolled 200 stone workers. After excluding 5 subjects with asthma and 16 subjects who took steroids or nonsteroidal anti-inflammatory drugs, a total of 179 subjects were used in the final analyses, which included 25 cases and 154 controls. By CDA, 88.8% of subjects were correctly discriminated by their exposure status and the presence of pneumoconiosis. After excluding the VOCs of automobile exhaust and cigarette smoking, pentane and C5-C7 methylated alkanes constituted the major VOCs in the breath of persons with pneumoconiosis. Using the prediction score generated from PCA, the ROC-AUC was 0.88 (95% CI = 0.80—0.95), and the mean ROC-AUC of 5-fold cross-validation was 0.90. The breath test had good accuracy for pneumoconiosis diagnosis.ConclusionThe analysis of breath VOCs has potential in the screening of pneumoconiosis for its non-invasiveness and high accuracy. We suggest that a multi-centre study is warranted and that all procedures must be standardized before clinical application.

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Section: Methodsmentioning

confidence: 99%

Development of breath test for pneumoconiosis: a case-control study

et al. 2017

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“…(5) La evolución y el pronóstico de los pacientes con fibrosis quística dependen del tipo de mutación genética, edad, estado nutricional y respuesta ante el tratamiento antibiótico. (8) Al respecto, se presenta un caso de una niña diagnosticada de fibrosis quística que desarrolló una complicación de pancreatitis.…”

Section: Introductionunclassified

Una Paciente pediátrica diagnosticada con fibrosis quística con pronóstico reservado

Guijarro¹,

Jácome

Haro

2019

EUGENIO ESPEJO

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La fibrosis quística constituye una enfermedad autosómica recesiva producida por una alteración del brazo largo del cromosoma 7 (7q31.2). Al respecto se presenta el caso de un paciente de género femenino de 10 años, que acude a una institución de salud del segundo nivel de atención, por presentar dolor abdominal dolor abdominal tipo cólico que inicia en epigastrio y se irradia a hipocondrio bilateral; la misma que presenta diagnóstico de fibrosis quística con tres años de evolución; cuyos valores de amilasa y lipasa permitieron establecer diagnóstico presuntivo de pancreatitis, complicación que no resulta frecuente en pacientes pediátricos. El cuadro clínico permitió observar particularidades que le hacen inusual para ese grupo etario, al observarse complicaciones respiratorias y al desarrollo de pancreatitis. Los protocolos de manejo de la enfermedad, seguidos en las instituciones médicas involucradas, estuvieron acorde con los estándares establecidos a nivel nacional e internacional.

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Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep

Cited by 2 publications

References 143 publications

Development of breath test for pneumoconiosis: a case-control study

Development of breath test for pneumoconiosis: a case-control study

Una Paciente pediátrica diagnosticada con fibrosis quística con pronóstico reservado

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