Sleep and immunity in times of COVID-19

Silva, Eduardo de Sousa Martins e; Ono, Ben Hur Vitor Silva; Souza, José Carlos

doi:10.1590/1806-9282.66.s2.143

Cited by 85 publications

(54 citation statements)

References 16 publications

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“…These data allow us to speculate that the same could be true in respect of sleep deprivation and COVID-19, including an increased risk of becoming infected, a poorer prognosis, and reduced efficacy of vaccines. The theoretical immunological threats posed by sleep deprivation in the context of COVID-19 have already been discussed, both in general terms (Mônico-Neto et al, 2020;Silva et al, 2020b) and in relation to specific populations (such as shift workers; Silva et al, 2020a). Although no studies have yet been published that evaluate this relationship among older adults, the indirect evidence indicates that the same might be expected in the older population.…”

Section: Sleep Deprivationmentioning

confidence: 99%

Sleep in Older Adults and Its Possible Relations With COVID-19

Pires

Ishikura

Xavier

et al. 2021

Front. Aging Neurosci.

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Since the beginning of the COVID-19 pandemic, older adults have been found to be a highly vulnerable group, with a higher prevalence of severe cases and negative outcomes. Research has focused on the reasons why older adults are at greater risk; Sleep-related factors have been suggested as one possible explanation for this. An individual’s sleep pattern undergoes significant changes over the course of their life. In older adults a specific sleep profile can be observed, one characterized by advanced sleep timing, a morningness preference, longer sleep-onset latency, shorter overall sleep duration, increased sleep fragmentation, reduced slow-wave sleep and, increased wake time after sleep onset. Additionally, an increased prevalence of sleep disorders can be observed, such as obstructive sleep apnea and insomnia. Previous research has already linked sleep disorders (especially sleep apnea) with COVID-19, but few studies have focused specifically on the older population. We believe that the intrinsic sleep patterns of older adults, and the prevalence of sleep disorders in this population, may be important factors that could explain why they are at a greater risk of negative COVID-19 outcomes. In this review, we discuss the relationship between sleep and COVID-19 among older adults, focusing on three different aspects: (1) Sleep-related issues that might increase the likelihood of getting infected by SARS-COV-2; (2) Sleep disturbances that might increase the predisposition to worse COVID-19 prognosis and outcomes; and (3) COVID-19-related aspects affecting community-dwelling older adults, such as social isolation, quarantine, and home confinement, among others, that might impact sleep.

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Section: Sleep Deprivationmentioning

confidence: 99%

Sleep in Older Adults and Its Possible Relations With COVID-19

Pires

Ishikura

Xavier

et al. 2021

Front. Aging Neurosci.

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“…Los PDS se han asociado al estado de ánimo depresivo, ansiedad y estrés. Inducen disminución de la calidad de vida, están relacionados con problemas crónicos sanitarios, son marcadores de riesgo cardiovascular y, además, son considerados un problema de salud pública (7)(8)(9)(10)(11)(12).…”

Section: Introductionunclassified

Prevalencia de problemas de sueño en mujeres climatéricas colombianas durante la pandemia COVID-19

Monterrosa-Castro

Monterrosa-Blanco

2021

Rev. Colomb. Obstet. Ginecol.

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Objetivo: elaborar una aproximación a la prevalencia de los problemas de sueño (PDS) en mujeres climatéricas colombianas durante la pandemia COVID-19. Materiales y Métodos: estudio transversal que pertenece al proyecto de investigación Calidad de Vida en la Menopausia y Etnias Colombianas bajo condiciones de pandemia [CAVIMEC+COVID STUDY]. Se incluyeron mujeres naturales y residentes en Colombia entre 40 y 59 años, quienes en los primeros cinco días de junio del 2020 participaron de forma anónima y voluntaria, previo consentimiento informado en el diligenciamiento de un formulario alojado en una plataforma virtual. Los PDS fueron identificados con el tercer ítem de Menopause Rating Scale. Se exploraron características sociodemográficas, la presencia y severidad de los PDS y el estado menopáusico. Se hace estadística descriptiva. Resultados: participaron 984 mujeres, la mediana de edad fue 47,0 [RIC: 42,0-53,5] años. El 84,5% de las participantes eran mestizas, el 13,7% afrodescendientes y 1,7% indígenas. El 39,3% posmenopáusicas. El 70% residían en la región caribe colombiana. Informaron PDS 637 (64,7%) de las participantes y 112 (11,3%) tenían PDS severos. Las posmenopáusicas informaron un 65,1% de PDS, en forma severa el 12,2%, y las premenopáusicas informaron 64,5%, en forma severa el 10,1%. Conclusiones: los PDS podrían ser un problema frecuente en las mujeres en estado premenopáusico y postmenopáusico. Se debe explorar este problema en la consulta ginecológica para ofrecer soluciones. Se requieren estudios poblacionales que confirmen estas observaciones.

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“…Further, the presence of ACE-2 receptors in the brainstem area that regulate respiration could also invoke sleep-related breathing disorders, in particular, among patients of obstructive sleep apnea who have recovered from COVID-19. Lastly, invasion of the central nervous system has not only short-term but also long-term effects that ultimately can induce neurodegeneration, making the sleep disturbances chronic [ 12 ]. Because of these reasons, sleep problems are seen not only during the acute infection but may also run a chronic course and they have a definite biological basis [ 8 ].…”

mentioning

confidence: 99%

“…Considering these findings, Silva et al [ 12 ] proposed that sleep problems during the COVID-19 pandemic are multifactorial in origin. They proposed that ongoing stress, change in circadian rhythm due to altered light exposure during the lockdown, immediate and long-term consequences of immune response to SARS-CoV-2 infection and changes in sleep/wake patterns all contribute to pave way for immediate and long-term sleep disturbances [ 12 ].…”

mentioning

confidence: 99%

“…Sleep problems may appear late in the course of COVID-19, even after patients recover from the acute infection. It has been suggested that recovered patients from SARS-CoV-2 infection should be followed up to look for neurodegenerative disorders such as Parkinson’s disease, Multiple Sclerosis, and Narcolepsy, plausible mechanisms of which have been discussed earlier [ 12 ]. Similarly, incipient fibrotic changes in the lungs make many of the survivors to develop obstructive sleep apnea and sleep-related hypoventilation syndromes in long term [ 11 ].…”

mentioning

confidence: 99%

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SARS-CoV-2 Infection: Paving Way for Sleep Disorders in Long Term!

Gupta

Pandi-Perumal²

2021

Sleep Vigilance

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COVID-19 pandemic has compelled health policymakers to think of health issues from a new perspective. While on one hand, this pandemic led to the exhaustion of health resources in many geographical areas, on the other hand, this infectious disease affected the provision of medical care to patients with other medical disorders. In addition, several studies have suggested that despite being primarily a respiratory virus, SARS-CoV-2 also influences emotions, feelings, behavior, and sleep, all functions governed by the brain, leading to "mental health" consequences.Many studies have been conducted to assess the impact of the COVID-19 pandemic on mental health and sleep disorders. Based on the findings of these studies, recently systematic reviews and meta-analyses were also published [1][2][3][4][5]. These papers reported a higher prevalence of anxiety, depression, and poor sleep quality among the general population, among medical healthcare workers including physicians and nurses, and among subjects suffering from COVID-19 infection, compared to population prevalence [1][2][3][4][5].Deng et al.[1], in a meta-analysis where most of the included studies were from China reported that the prevalence of poor sleep quality and insomnia among patients having COVID-19 was 34%. Although studies included in this meta-analysis used different methods to assess sleep quality and insomnia, ranging from validated questionnaires such as Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) to face-to-face interviews, still the prevalence was greater than population prevalence. However, another meta-analysis, which better represented other geographical areas than the study mentioned earlier, reported that the prevalence of sleep disorders among patients having COVID-19 infection was as high as 75% [3]. Prevalence of sleep disturbance was lower in general population and

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Sleep and immunity in times of COVID-19

Cited by 85 publications

References 16 publications

Sleep in Older Adults and Its Possible Relations With COVID-19

Sleep in Older Adults and Its Possible Relations With COVID-19

Prevalencia de problemas de sueño en mujeres climatéricas colombianas durante la pandemia COVID-19

SARS-CoV-2 Infection: Paving Way for Sleep Disorders in Long Term!

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