SLC2A2 Gene (Glucose Transporter 2) Variation is Associated with an Increased Risk of Developing T2d in an Ethnic Population of Saudi Arabia

Almutairi, Fahad M.; Mir, Rashid; Abu-Duhier, Faisal; Khan, Roaid; Harby, K.; Elfaki, Imadeldin

doi:10.5958/0976-5506.2019.00118.9

Cited by 7 publications

(6 citation statements)

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“…The SNPs can also be the cause of variation in drug response between individuals [21]. Moreover, they can be the cause of several pathophysiological disorders such as diabetes [22][23][24][25] cancers or atherosclerosis [21,[26][27][28][29][30][31], obesity, hypertension, psychiatric disorders [20], inflammatory and autoimmune diseases [32]. SNPs at the miRNA gene may enhance, reduce expression, change maturation of miRNA, or disrupt miRNA-mRNA binding [33].…”

Section: Introductionmentioning

confidence: 99%

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Elfaki

Mir

et al. 2019

JPM

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MicroRNAs (miRNAs) are endogenous, small (18–23 nucleotides), non-coding RNA molecules. They regulate the posttranscriptional expression of their target genes. MiRNAs control vital physiological processes such as metabolism, development, differentiation, cell cycle and apoptosis. The control of the gene expression by miRNAs requires efficient binding between the miRNA and their target mRNAs. Genome-wide association studies (GWASs) have suggested the association of single-nucleotide polymorphisms (SNPs) with certain diseases in various populations. Gene polymorphisms of miRNA target sites have been implicated in diseases such as cancers, diabetes, cardiovascular and Parkinson’s disease. Likewise, gene polymorphisms of miRNAs have been reported to be associated with diseases. In this review, we discuss the SNPs in miRNA genes that have been associated with diabetes and atherosclerotic cardiovascular disease in different populations. We also discuss briefly the potential underlining mechanisms through which these SNPs increase the risk of developing these diseases.

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Section: Introductionmentioning

confidence: 99%

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Elfaki

Mir

et al. 2019

JPM

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“…The role of the rs8192675 SNP had not been studied in any of the diseases apart from diabetes as this SNP and gene is connected with the regulatory effect of metformin [22]. In Saudi Arabia, the rs8192675 SNP is already documented with T2DM [15]. Hence, we decided to study women with PCOS as there is a connection between T2DM and PCOS [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…In T2DM patients, SNP rs8192675 in the SLC2A2 gene was related with a better glucose response. The rs8192675 SNP was documented in the global studies, and both positive and negative associations were documented within different ethnicities [13,15,16,[28][29][30][31][32]. None of the meta-analysis studies have been focused towards rs8192675 and T2DM.…”

Section: Discussionmentioning

confidence: 99%

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Examining the Genetic Role of rs8192675 Variant in Saudi Women Diagnosed with Polycystic Ovary Syndrome

Alsobaie,

Alageel,

Ishfaq

et al. 2023

Diagnostics

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Polycystic ovary syndrome is a complex disorder defined by the Rotterdam criteria. Insulin resistance is a common factor for the development of type 2 diabetes mellitus among women with PCOS. The SLC2A2 gene has been identified as a T2DM gene by genome-wide association studies in the rs8192675 SNP. This study aimed to investigate the rs8192675 SNP in women diagnosed with PCOS on a molecular level and further for T2DM development in the Saudi women. In this case-control study, 100 PCOS women and 100 healthy controls were selected. Among 100 PCOS women, 28 women showed T2DM development. Genotyping for rs8192675 SNP was performed by PCR-RFLP analysis. Additionally, Sanger sequencing was performed to validate the RFLP analysis. The obtained data were used for a statistical analysis for the genotype and allele frequencies, logistic regression, and ANOVA analysis. The clinical data confirmed the positive association between FBG, FI, FSH, TT, TC, HDLc, LDLc, and family histories (p < 0.05). HWE analysis was associated in both the PCOS cases and the control individuals. Genotype and allele frequencies were associated in PCOS women and strongly associated with women with PCOS who developed T2DM (p < 0.05). No association was found in the logistic regression model or ANOVA analysis studied in women with PCOS (p > 0.05). A strong association was observed between the rs8192675 SNP and women with PCOS who developed T2DM using ANOVA analysis (p < 0.05). This study confirms that the rs8192675 SNP is associated with women with PCOS and strongly associated with women with PCOS with developed T2DM in Saudi Arabia.

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“…LDL–cholesterol is then released by the LDLR at an acidic pH for degradation by a lysosome which results in the release of free cholesterol and the return of the LDLR to the cell surface [9]. Genome-wide association studies (GWASs) have discovered certain novel gene loci that reproducibly associate with diseases [11,12,13], including CAD [14,15,16,17,18,19,20] and atherosclerosis [21,22]. Mutations in the LDLR gene have been reported to cause familial hypercholesterolemia [18,23].…”

Section: Introductionmentioning

confidence: 99%

LDLR Gene Polymorphisms (rs5925 and rs1529729) Are Associated with Susceptibility to Coronary Artery Disease in a South Indian Population

et al. 2019

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Cardiovascular diseases (CVD) are a major cause of death in India and worldwide. Atherosclerosis is caused by the interaction of environmental and genetic factors. Hypercholesterolemia is an example of a classical risk factor for CVD. The low-density lipoprotein receptor (LDLR) is one of the regulating mechanisms the liver uses for cholesterol homeostasis. Gene variations in the LDLR have been reported to cause hypercholesterolemia and consequently CVD. We investigated the association of polymorphisms in the LDLR (rs5925 and rs1529729) with coronary artery disease (CAD) in 200 coronary artery disease patients and 200 matched healthy controls using allele-specific PCR (AS-PCR). The results indicated that the CT genotype of the rs1529729 polymorphism was associated a decreased susceptibility to CAD with an odds ratio (OR) = 0.42 (95% confidence interval (CI), 0.23–0.77), risk ratio (RR) = 0.59 (0.39–0.89), P = 0.0047. The TT genotype of the rs1529729 polymorphism was also associated with decreased susceptibility to CAD with an OR = 0.19 (95% CI, 0.076–0.47), RR = 0.57 (0.47–0.69), P = 0.0003. The GA genotype of the rs5925 polymorphism was associated with decreased susceptibility to CAD with an OR = 0.45 (95% CI, 0.27–0.75), RR = 0.65 (0.47–0.88), P = 0.002. We concluded that the CT and TT genotypes of the rs1529729 polymorphism and the GA genotype of the rs5925 polymorphism are probably associated with decreased susceptibility to CAD. The simplicity of AS-PCR makes it particularly suitable for the rapid, large-scale screening of gene variabilities in the LDLR. AS-PCR could provide significant benefits in clinical applications with its ability to amplify a lower quantity of samples in a cost-saving manner. Nevertheless, these findings need to be validated in well-designed studies with larger sample sizes and in different populations.

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SLC2A2 Gene (Glucose Transporter 2) Variation is Associated with an Increased Risk of Developing T2d in an Ethnic Population of Saudi Arabia

Cited by 7 publications

References 0 publications

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Examining the Genetic Role of rs8192675 Variant in Saudi Women Diagnosed with Polycystic Ovary Syndrome

LDLR Gene Polymorphisms (rs5925 and rs1529729) Are Associated with Susceptibility to Coronary Artery Disease in a South Indian Population

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