SLC17A3 rs9379800 and Ischemic Stroke Susceptibility at the Northern Region of Malaysia

Ching, Shu Chai; Wen, Lim Jing; Ismail, Nor Ismaliza Mohd; Looi, Irene; Kooi, Cheah Wee; Peng, Long Soo; Mui, Lee Soon; Tamibmaniam, Jayashamani; Muninathan, Prema; Hooi, Ong Beng; Ali, Siti Maisarah Md; Hassan, Muhammad Radzi Abu; Mohamad, Mohd Saberi; Griffiths, Lyn R.; Wei, Loo Keat

doi:10.1016/j.jstrokecerebrovasdis.2021.105908

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…In consonance, the neglectful condition has been associated with having a preterm birth ( Sulaiman et al, 2021 ) with lower birth weight ( Strathearn et al, 2001 ) and with developing obesity over the life course ( Danese and Tan, 2014 ; Strathearn et al, 2020 ). ZFP57 ( Chen et al, 2019 ), FGFR2 ( Xi et al, 2014 ), and WNK4 ( Fackler et al, 2011 ), have been related to breast cancer, and WNK4 also with hypertension ( Mu et al, 2011 ; Ching et al, 2021 ) associated with suffering coronary heart disease ( Deschênes et al, 2021 ), conditions that are common among the long-term consequences of the abuse and neglect ( Strathearn et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

et al. 2022

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Studies of DNA methylation have revealed the biological mechanisms by which life adversity confers risk for later physical and mental health problems. What remains unknown is the “biologically embedding” of maternal adverse experiences resulting in maladaptive parenting and whether these epigenetic effects are transmitted to the next generation. This study focuses on neglectful mothering indexed by a severe disregard for the basic and psychological needs of the child. Using the Illumina Human Methylation EPIC BeadChip in saliva samples, we identified genes with differentially methylated regions (DMRs) in those mothers with (n = 51), versus those without (n = 87), neglectful behavior that present similar DMRs patterns in their children being neglected versus non-neglected (n = 40 vs. 75). Mothers reported the emotional intensity of adverse life events. After covariate adjustment and multiple testing corrections, we identified 69 DMRs in the mother epigenome and 42 DMRs in the child epigenome that were simultaneously above the α = 0.01 threshold. The common set of nine DMRs contained genes related to childhood adversity, neonatal and infant diabetes, child neurobehavioral development and other health problems such as obesity, hypertension, cancer, posttraumatic stress, and the Alzheimer’s disease; four of the genes were associated with maternal life adversity. Identifying a shared epigenetic signature of neglect linked to maternal life adversity is an essential step in breaking the intergenerational transmission of one of the most common forms of childhood maltreatment.

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Section: Discussionmentioning

confidence: 99%

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

et al. 2022

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“…Patients with tumors, brain trauma, cerebral hemorrhage and cerebrovascular malformations were excluded. The control group was from patients who received physical examinations in the hospital during the same period without any family history of stroke, hypertension, diabetes and cardiovascular disease ( 3 , 17 ). Trained staff administered questionnaires to participants to collect demographic data (including age, sex, smoking and drinking habits, and disease history), while collecting venous blood samples from recruiters who had fasted for at least 8 h. The protocol was approved by the Ethics Committee of this hospital and complies with the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…Stroke is caused by cerebrovascular disorders, including ischemic stroke (IS) and hemorrhagic stroke (HS), of which IS accounts for 70 to 90% ( 1 , 2 ). High morbidity, high recurrence, high mortality, high disability and low cure rate are the main characteristics of IS ( 3 ). As a multifactorial complex neurological disorder, stroke involves clinical, environmental and genetic factors ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of MMP2 rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population

Yang

Zhang

et al. 2022

Front. Neurol.

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BackgroundIschemic stroke (IS) is a complex neurological disease affected by genetics and environment. Matrix metalloproteinase-2 (MMP2) is involved in extracellular matrix (ECM) degradation, inflammation and angiogenesis to regulate the development and recovery of IS.PurposesThe aim of this study was to explore the association of rs1053605, rs243849 and rs14070 in MMP2 with the risk of IS in Chinese Shaanxi population.MethodsIn this study, 677 IS patients and 681 normal controls were recruited. Rs1053605, rs243849 and rs14070 in MMP2 were genotyped. Logistic regression analysis was applied to evaluate the association of rs1053605, rs243849 and rs14070 in MMP2 with IS susceptibility and the association of environmental factors with MMP2 genetic susceptibility to IS.ResultsThe results of the overall analysis demonstrated that rs14070 in MMP2 significantly reduced the risk of IS in Chinese Shaanxi population (OR = 0.767, 95% CI = 0.619–0.952, P = 0.016). Subgroup analysis illustrated that rs243849 in MMP2 evidently increased the risk of IS among drinkers, while rs14070 in MMP2 apparently reduced IS susceptibility among females, participants with aged >55, smokers and drinkers.ConclusionsCollectively, rs243849 and rs14070 in MMP2 were significantly associated with the risk of IS in Chinese Shaanxi population, and the effect of MMP2 to IS may be associated with its genetic susceptibility.

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Genetic Polymorphisms of Ischemic Stroke in Asians

Besin,

Yulianti,

Notopuro

et al. 2023

Clinica Chimica Acta

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SLC17A3 rs9379800 and Ischemic Stroke Susceptibility at the Northern Region of Malaysia

Cited by 5 publications

References 44 publications

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

Impact of MMP2 rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population

Genetic Polymorphisms of Ischemic Stroke in Asians

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