Impact of MMP2 rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population

Li, Shilin; Yang, Shiyao; Zhang, Xiaobo; Zhang, Jie; Zhang, Xiao; Li, Weiping; Niu, Xiaochen; Shi, Wenzhen; Zhang, Gejuan; Chang, Mingze; Tian, Ye

doi:10.3389/fneur.2022.931437

Cited by 3 publications

(2 citation statements)

References 32 publications

(61 reference statements)

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“…The common risk factors for stroke include age, gender, smoking, alcohol abuse, diabetes, hyperlipidemia, and hyperhomocysteinemia [7,8]. In addition to common risk factors, the International Stroke Genetics Consortium states that genetic factors may account for 50% of an individual's risk of stroke and may play a key regulatory role in pathophysiological processes, such as brain cell necrosis and ischemia-reperfusion injury [9][10][11][12]. Therefore, there is an urgent need to further explore the relationship between genetic polymorphisms and IS [13].…”

Section: Introductionmentioning

confidence: 99%

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

Wang,

Shen,

Gao

et al. 2024

Preprint

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Background Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS. The quinone oxidoreductase 1 gene (NQO1) has antioxidant, anti-inflammatory, and cytoprotective properties. Thus, in this study, we investigated the relationship between NQO1 gene polymorphism and the risk of IS. Methods Peripheral blood was collected from 143 patients with IS and 124 healthy controls in Yunnan, China, and NQO1 rs2917673, rs689455, and rs1800566 were genotyped. Logistic regression was used to analyze the relationship between the three NQO1 loci and IS susceptibility. The difference in the expression levels of NQO1 between the control and IS groups was verified using public databases and enzyme-linked immunosorbent assay. Results The rs2917673 locus increased the risk of IS by 2.375 times in TT genotype carriers under the co-dominance model compared with CC carriers and was statistically associated with the risk of IS (P = 0.046). In the recessive model, TT genotype carriers increased IS risk by 2.407 times compared with CC/CT carriers and were statistically associated with the risk of IS (P = 0.033). Conclusions NQO1 rs2917673 polymorphism is significantly associated with IS. Mutant TT carriers are risk factors for IS.

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Section: Introductionmentioning

confidence: 99%

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

Wang,

Shen,

Gao

et al. 2024

Preprint

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“…At present, a meta-analysis showed that MMP-9 and MMP-12 gene polymorphisms may be risk factors for IS, whereas MMP-1, MMP-2 , and MMP-3 were not associated with the risk of IS ( 15 ). Moreover, the latest study has found that rs243849 and rs14070 in MMP-2 are significantly related to the risk of IS in the Shaanxi population from China ( 16 ). However, no significant association between MMP-9 genetic variants and intracerebral hemorrhage (ICH) susceptibility was reported ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility

Tian

2023

Front. Neurol.

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PurposeIschemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out the relationship between MMP-9 polymorphisms and IS susceptibility.MethodsA total of 700 IS patients and 700 healthy controls were recruited. The single nucleotide polymorphism (SNP) markers of the MMP-9 gene were genotyped by the MassARRAY analyzer. Multifactor dimensionality reduction (MDR) was applied to generate SNP–SNP interaction. Furthermore, the relationship between genetic variations (allele and genotype) of the MMP-9 gene and IS susceptibility was analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOur results demonstrated that rs2250889 could significantly increase the susceptibility to IS in the codominant, dominant, overdominant, and log-additive models (p < 0.05). Further stratification analysis showed that compared with the control group, rs2250889 was associated with IS risk in different case groups (age, female, smoking, and non-drinking) (p < 0.05). Based on MDR analysis, rs2250889 was the best model for predicting IS risk (cross-validation consistency: 10/10, OR = 1.56 (1.26–1.94), p < 0.001).ConclusionOur study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS.

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NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

Wang,

Shen,

Gao

et al. 2024

BMC Med Genomics

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Background Ischemic stroke (IS) is a major cause of death and disability worldwide. Genetic factors are important risk factors for the development of IS. The quinone oxidoreductase 1 gene (NQO1) has antioxidant, anti-inflammatory, and cytoprotective properties. Thus, in this study, we investigated the relationship between NQO1 gene polymorphism and the risk of IS. Methods Peripheral blood was collected from 143 patients with IS and 124 the control groups in Yunnan, China, and NQO1 rs2917673, rs689455, and rs1800566 were genotyped. Logistic regression was used to analyze the relationship between the three NQO1 loci and IS susceptibility. The difference in the expression levels of NQO1 between the control groups and IS groups was verified using public databases and enzyme-linked immunosorbent assay. Results The rs2917673 locus increased the risk of IS by 2.375 times in TT genotype carriers under the co-dominance model compared with CC carriers and was statistically associated with the risk of IS (OR = 2.375, 95% CI = 1.017–5.546, P = 0.046). In the recessive model, TT genotype carriers increased IS risk by 2.407 times compared with CC/CT carriers and were statistically associated with the risk of IS (OR = 2.407, 95% CI = 1.073–5.396, P = 0.033). Conclusions NQO1 rs2917673 polymorphism is significantly associated with IS. Mutant TT carriers are risk factors for IS.

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Impact of MMP2 rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population

Cited by 3 publications

References 32 publications

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility

NQO1 polymorphism and susceptibility to ischemic stroke in a Chinese population

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