Skull and vertebral bone marrow in central nervous system inflammation

Ren, Honglei; Liu, Qiang

doi:10.1016/j.fmre.2023.01.012

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…Recent studies have characterized a lymphopoietic niche, bordering the CNS, that is a local source of meningeal B cells ( Brioschi et al, 2021 ). These cells are able to transverse from the niche to the meninges through ossified vascular channels ( Ren and Liu, 2023 ). While the majority of B cells in the meninges are tissue resident, the presence of peripheral B cells has been shown to increase with age, due to greater accumulation of ABCs ( Brioschi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Intruders or protectors – the multifaceted role of B cells in CNS disorders

Aspden,

Murphy,

Kashlan

et al. 2024

Front. Cell. Neurosci.

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B lymphocytes are immune cells studied predominantly in the context of peripheral humoral immune responses against pathogens. Evidence has been accumulating in recent years on the diversity of immunomodulatory functions that B cells undertake, with particular relevance for pathologies of the central nervous system (CNS). This review summarizes current knowledge on B cell populations, localization, infiltration mechanisms, and function in the CNS and associated tissues. Acute and chronic neurodegenerative pathologies are examined in order to explore the complex, and sometimes conflicting, effects that B cells can have in each context, with implications for disease progression and treatment outcomes. Additional factors such as aging modulate the proportions and function of B cell subpopulations over time and are also discussed in the context of neuroinflammatory response and disease susceptibility. A better understanding of the multifactorial role of B cell populations in the CNS may ultimately lead to innovative therapeutic strategies for a variety of neurological conditions.

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Section: Introductionmentioning

confidence: 99%

Intruders or protectors – the multifaceted role of B cells in CNS disorders

Aspden,

Murphy,

Kashlan

et al. 2024

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…From the perspective of the nervous system, the issue includes discussions on the interaction between the nervous system and immune system [13] , the emerging strategy for treating neurological disorders through microglia replacement [14] , the regulatory roles of meningeal lymphatic vasculature [15] , and the relatively overlooked brain cell type, fibroblast [16] . From the viewpoint of the peripheral system, this special issue also delves into the contribution of the peripheral autoimmune system [17] and bone marrow cells [18] to the brain, as well as the regulatory roles in the pancreas [19] and skin [20] . Additionally, a comprehensive review summarizes the current state and future prospects of neuroimmunology [21] .…”

mentioning

confidence: 99%