Intruders or protectors – the multifaceted role of B cells in CNS disorders
James W. Aspden,
Matthew A. Murphy,
Rommi D. Kashlan
et al.
Abstract:B lymphocytes are immune cells studied predominantly in the context of peripheral humoral immune responses against pathogens. Evidence has been accumulating in recent years on the diversity of immunomodulatory functions that B cells undertake, with particular relevance for pathologies of the central nervous system (CNS). This review summarizes current knowledge on B cell populations, localization, infiltration mechanisms, and function in the CNS and associated tissues. Acute and chronic neurodegenerative patho… Show more
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