Skin wound regeneration with bioactive glass-gold nanoparticles ointment

Mârza, Sorin Marian; Magyari, Klára; Bogdan, Sidonia; Moldovan, Mirela; Peștean, Cosmin; Nagy, András; Tăbăran, Flaviu; Licărete, Emilia; Suarasan, Sorina; Dreancă, Alexandra; Baia, Lucian; Papuc, I.

doi:10.1088/1748-605x/aafd7d

Cited by 55 publications

(41 citation statements)

References 39 publications

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“…36 Further, the same research group prepared silver NPs using aqueous extract of Allium saralicum and evaluated for biological activity against a panel of bacterial and fungal strains and documented promising inhibition profiles. [37][38][39] Functionally modified textiles are receiving greater attention and significant growth due to the wide awareness in case of hygiene and health considerations. Particularly, fabrics bearing antibacterial properties can offer synergistic and dual beneficial effects to the textiles.…”

Section: Introductionmentioning

confidence: 99%

<p>Phyto-Engineered Gold Nanoparticles (AuNPs) with Potential Antibacterial, Antioxidant, and Wound Healing Activities Under in vitro and in vivo Conditions</p>

Boomi

Ganesan²,

Poorani³

et al. 2020

IJN

102

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Background: A diabetic ulcer is one of the major causes of illness among diabetic patients that involves severe and intractable complications associated with diabetic wounds. Hence, a suitable wound-healing agent is urgently needed at this juncture. Greener nanotechnology is a very promising and emerging technology currently employed for the development of alternative medicines. Plant-mediated synthesis of metal nanoparticles has been intensively investigated and regarded as an alternative strategy for overcoming various diseases and their secondary complications like microbial infections. Hence, we are interested in developing phyto-engineered gold nanoparticles as useful therapeutic agents for the treatment of infectious diseases and wounds effectively. Methods and Results: We have synthesized phyto-engineered gold nanoparticles from the aqueous extract of Acalypha indica and characterized using advanced bio-analytical techniques. The surface plasmon resonance feature and crystalline behavior of gold nanoparticles were revealed by ultraviolet-visible spectroscopy and X-ray diffraction, respectively. High-performance liquid chromatography analysis of the extract demonstrated the presence of different constituents, while major functional groups were interpreted by the Fourier-transform infrared spectroscopy as the various stretching vibrations appeared for important O-H (3443 cm −1), C=O (1644 cm −1) and CO (1395 cm −1) groups. Scanning electron microscopy, high-resolution transmission electron microscopy results revealed a distribution of spherical and rod-like nanostructures with 20 nm of size. The gold nanoparticle-coated cotton fabric was evaluated for the antibacterial activity against Staphylococcus epidermidis and Escherichia coli bacterial strains which revealed remarkable inhibition at the zone of inhibition of 31 mm diameter against S. epidermidis. Further, antioxidant activity was tested for their free radical scavenging property, and the maximum antioxidant activity of the extract containing gold nanoparticles was found to be 80% at 100 µg/mL. The potent free radical scavenging property of the nanoparticles is observed at IC 50 value 16.25 µg/mL. Moreover, in vivo wound-healing activity was carried out using BALB/c mice model with infected diabetic wounds and observed the stained microscopic images at different time intervals (day 2, day 7 and day 15). It was noted that in 15 days, the wound area is completely re-epithelialized due to the presence of different morphologies such as spherical, needle and triangle nanoparticles. The reepithelialization layer is fully covered by nanoparticles on the wound area and also collagen filled in the scar tissue when compared with the control group. Conclusion: The pharmacological evaluation results of the study indicated an encouraging antibacterial and antioxidant activity of the greener synthesized gold nanoparticles tethered with aqueous extract of Acalypha indica. Moreover, we demonstrated enhanced in vivo wound-healing efficiency of the synthesized gold nano...

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Section: Introductionmentioning

confidence: 99%

<p>Phyto-Engineered Gold Nanoparticles (AuNPs) with Potential Antibacterial, Antioxidant, and Wound Healing Activities Under in vitro and in vivo Conditions</p>

Boomi

Ganesan²,

Poorani³

et al. 2020

IJN

102

View full text Add to dashboard Cite

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“…In addition to enhancing 3D scaffolds, another attractive advantage of using GNPs in BTE is to form the delivery system. GNPs' large surface-to-volume ratio, ability to penetrate cell membranes, ease of functionalization and targeting [6,12], and its ability to promote wound healing and angiogenesis [117] make them a powerful tool for delivery systems. That is, in addition to growth factors, drugs, and genetic material, it also has the value of being delivered.…”

Section: Delivery Systemsmentioning

confidence: 99%

Advances in the application of gold nanoparticles in bone tissue engineering

Xia

et al. 2020

J Biol Eng

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The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., GNPs characterized with large surface area to volume ratio, biocompatibility, medical imaging property, hypotoxicity, translocation into the cells, high reactivity, and other properties, perform distinct functions in BTE. However, the low stability of GNPs in the biotic environment makes them in the requirements of modification or recombination before being used. After being combined with the advantages of other materials, the structures of GNPs have exhibited great potential in stem cells, scaffolds, delivery systems, medical imaging, and other aspects. This review will focus on the advances in the application of GNPs after modification or recombination with other materials to BTE.

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“…However, the application of these inorganic nanoparticle-based wound care products is limited, owing to toxicity concerns as well as long-term tissue deposition (argyrosis). Additionally, granuloma formation has occasionally been observed following the application of inorganic nanoparticles to wounds [ 117 ]. Issues such as long-term tissue deposition and the degradation of the inorganic nanoparticles compromise their application for human use.…”

Section: Disadvantages and Dangersmentioning

confidence: 99%

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

2020

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Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

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Skin wound regeneration with bioactive glass-gold nanoparticles ointment

Cited by 55 publications

References 39 publications

<p>Phyto-Engineered Gold Nanoparticles (AuNPs) with Potential Antibacterial, Antioxidant, and Wound Healing Activities Under in vitro and in vivo Conditions</p>

<p>Phyto-Engineered Gold Nanoparticles (AuNPs) with Potential Antibacterial, Antioxidant, and Wound Healing Activities Under in vitro and in vivo Conditions</p>

Advances in the application of gold nanoparticles in bone tissue engineering

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

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