Skin TRPA1 ion channel participates in thermoregulatory response to cold. Comparison with the effect of TRPM8

Козырева, Т. В.; Kozaruk, V. P.; Meyta, E.S.

doi:10.1016/j.jtherbio.2019.06.010

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…However, there were pronounced changes in the recovery of blood flow and tail blood volume under the influence of 0.5% AITC (Figure 4 and Figure 5, dark bars, bottom). The mean rate for blood flow recovery at 0.5% AITC application was 0.3 ± 0.07 ml/min 2 against 0.1 ± 0.05 the metabolic response to cooling with the most use of carbohydrates as an oxidation substrate, and TRPA1 for the powerful second phase of the metabolic response with increased use lipids [9]. Therefore, two cold-sensitive ion channels localized in the skin sensory nerves have different influences on the parameters of the cardiovascular system and the influence of each of these two ion channels depends on the degree of their activation.…”

Section: The Effect Of 05%mentioning

confidence: 95%

“…It is well known that TRPA1 is localized on the skin sensory nerves presumably perceiving a sufficiently strong cold, participating in mechanisms of neurogenic inflammation and pain [3][4][5][6][7][8] TRPA1 participates also in the formation of a thermoregulatory response to cooling [9]. It is known that the cardiovascular system is actively involved in the body's response to both cooling and pain.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Tv¹,

Es²

2021

Int Arch Clin Pharmacol

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The effect of different activation of the skin TRPA1 ion channel on the parameters of the cardiovascular system was studied in rats with hereditary stress-induced hypertension while recovery from anesthesia. The activation of the TRPA1 ion channel was performed by application to skin its agonist -allyl isothiocyanate (AITC) in two concentrations 2.5% and 0.5%. The following parameters were measured that characterize the work of the cardiovascular system: Blood pressure (systolic, diastolic, and mean), heart rate, blood flow, and tail blood volume. Stimulation of the TRPA1 ion channel by 2.5% AITC resulted in a diminishing rate of increase in blood pressure and a sharp increase in heart rate while recovering from anesthesia. The mean rate of the arterial pressure rise during recovery from anesthesia was 0.4 ± 0.16 mmHg/min compared to 1.4 ± 0.19 mmHg/ min in control (solvent application), P < 0.01. The heart rate increase was 4.7 ± 0.28 beats/min2 compared to 0.6 ± 0.39 beats/min2 in control (P < 0.001). Parameters of blood flow and the tail blood volume were not significantly changed at 2.5% AITC compared to control. The effect of 0.5% AITC on cardiovascular parameters was another. There was no influence on the recovery of arterial pressure and the heart rate, but there was a pronounced acceleration in the recovery of blood flow and tail blood volume after anesthesia. The mean rate for blood flow recovery at 0.5% AITC application was 0.3 ± 0.07 ml/min2 against 0.1 ± 0.05 ml/min2 in control (P < 0.03) and for the tail blood volume was 1.2 ± 0.33 μl/ min against 0.4 ± 0.14 μl/min in control (P < 0.02). Thus, the influence of the skin TRPA1 ion channel on the parameters of the cardiovascular system depends on the degree of its activation. A low level of the TRPA1 stimulation enhanced the blood flow, while a higher level of the TRPA1 activation discouraged to increase in arterial pressure and significantly increased the heart rate. The results suggest the possibility of the therapeutic use of TRPA1 ion channel activation.

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Section: The Effect Of 05%mentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Tv¹,

Es²

2021

Int Arch Clin Pharmacol

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“…Kozyreva [27] explains that, in mammals, during a period of habituation to the cold, the proportion of low-frequency thermoreceptors associated with the cold (TRPM8), receptors that respond to temperatures between 24 and 25 • C, may decrease by 27%. However, when exposed to ambient temperatures between 28 and 30 • C, the expression of TRPM8 can increase up to 70% when compared to high-frequency receptors [28,29]. According to this change in the proportion of receptors, it is shown that TRPM8 detects the thermal stimuli associated with the cold, although it has been identified that TRPA1 can also contribute to cold signaling [30,31].…”

Section: Peripheral Thermoreceptor Activationmentioning

confidence: 99%

Hypothalamic Neuromodulation of Hypothermia in Domestic Animals

Mota-Rojas,

Ghezzi,

Hernández-Ávalos

et al. 2024

Animals

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When an organism detects decreases in their core body temperature, the hypothalamus, the main thermoregulatory center, triggers compensatory responses. These responses include vasomotor changes to prevent heat loss and physiological mechanisms (e.g., shivering and non-shivering thermogenesis) for heat production. Both types of changes require the participation of peripheral thermoreceptors, afferent signaling to the spinal cord and hypothalamus, and efferent pathways to motor and/or sympathetic neurons. The present review aims to analyze the scientific evidence of the hypothalamic control of hypothermia and the central and peripheral changes that are triggered in domestic animals.

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“…In CPT, a body part is immersed into cold water serving as a noxious stimulus. The low temperature activates nociceptive fibers [ 20 , 24 , 25 ], probably through low temperature sensitive ion channels TRPM8 [ 26 ] and TRPA1 [ 27 ] leading to increasing pain of mild to moderate intensity [ 28 ]. Although standardization in this method is difficult due to e.g., anthropometric differences, it is easy and commonly used and has been successfully employed in pain experiments.…”

Section: Introductionmentioning

confidence: 99%

Spatial summation of pain is associated with pain expectations: Results from a home-based paradigm

Nastaj,

Skalski,

Budzisz

et al. 2024

PLoS ONE

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The purpose of this study was to reproduce the previously observed spatial summation of pain effect (SSp) using non-laboratory procedures and commercial equipment. An additional aim was to explore the association between expectations and SSp. The Cold Pressor Task (CPT) was used to induce SSp. Healthy participants (N = 68) immersed their non-dominant hands (divided into 5 segments) into cold water (CPT). Two conditions were used 1) gradual hand immersion (ascending condition) and 2) gradual hand withdrawal (descending condition). Pain intensity was measured on a Visual Analogue Scale (VAS). Psychological factors, such as the participants’ expectations of pain intensity were also measured on a VAS. Results showed significant SSp (χ2(4) = 116.90, p < 0.001), reproduced with non-laboratory equipment in a home-based set-up. Furthermore, two novel findings were observed: i) there was a significant correlation between expectations and perceived pain, indicating a link between pain expectations and SSp, ii) spatial summation increased with the increase in duration exposure to the noxious stimulus (Wald χ2(8) = 80.80, p < 0.001). This study suggests that SSp is associated with pain expectations and can be formed by a mixture of excitatory and inhibitory mechanisms potentially driven by temporal characteristics of neural excitation. Moreover, this study proposes a new feasible way to induce SSp using a home-based set-up.

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Skin TRPA1 ion channel participates in thermoregulatory response to cold. Comparison with the effect of TRPM8

Cited by 11 publications

References 21 publications

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Hypothalamic Neuromodulation of Hypothermia in Domestic Animals

Spatial summation of pain is associated with pain expectations: Results from a home-based paradigm

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