Skin Testing in the Evaluation of Hymenoptera Allergy and Drug Allergy

Graham, Donna Melissa; McPherson, Holly M; Lieberman, Phil

doi:10.1016/s0889-8561(05)70208-3

Cited by 3 publications

(1 citation statement)

References 71 publications

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“…At present, the development of inflammatory pain drugs is mainly focused on non-opioid drugs, especially non-steroidal anti-inflammatory and analgesic drugs, but they are limited by their addictive properties, serious cardiovascular effects, and other side effects [ 2 - 4 ]. Some externally used drugs will cause skin allergies, and possess other undesirable traits [ 5 ]. Compared with chemical drugs, extracts of natural substances have the advantages of low development cost and few side effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E₂ pathway

Xiao

Kuang

et al. 2020

Korean J Pain

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Background: Zhongyi paste is a traditional Chinese medicine herbal paste that is externally applied to reduce inflammation and relieve pain. Methods: An acute foot swelling inflammation model in C57BL/6J mice was established by carrageenan-induced pathogenesis. Zhongyi paste raised the pain threshold and also reduced the degree of swelling in mice with carrageenan-induced foot swelling. Results: Analysis indicated that serum tumor necrosis factor-alpha, interleukin-1 beta, and prostaglandin E 2 (PGE 2) cytokine levels and PGE 2 levels in the paw tissue of the mice were decreased by Zhongyi paste treatment. The quantitative polymerase chain reaction and western blot results showed that Zhongyi paste downregulated the mRNA and protein expression of extracellular signal-regulated kinase 1/2 (ERK1/2), and cyclooxygenase-2 (COX-2), and also downregulated the mRNA expression of PGE 2. At the same time, the Zhongyi paste exerted a stronger effect as an external drug than that of indomethacin, which is an oral drug, and voltaren, which is an externally applied drug. Conclusions: Our results indicated that Zhongyi paste is a very effective drug to reduce inflammatory swelling of the foot, and its mechanism of action is related to regulation of the ERK1/2-COX-2-PGE 2 pathway.

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Section: Introductionmentioning

confidence: 99%

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E₂ pathway

Xiao

Kuang

et al. 2020

Korean J Pain

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Patients with negative skin tests

Kontou-Fili

2002

Current Opinion in Allergy and Clinical Immunology

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Ari Venomuna Bağli Anafi̇laksi̇: Kli̇ni̇k Deneyi̇mi̇mi̇z

AKÇAM,

KIRMIZITAŞ AYDOĞDU

2023

SDÜ Tıp Fakültesi Dergisi

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Amaç Arı alerjileri en sık anafilaksi nedenlerindendir ve şiddetli anafilaksi ile karakterizedir. Amacımız arı venomuna bağlı anafilaksi geçiren erişkin olgularda reaksiyona yol açan arı türleri ile gelişen anafilaksinin şiddeti, in-vivo ve in-vitro test sonuçları ile olguların demografik özelliklerini araştırmaktır. Gereç ve Yöntem Mart 2017- Haziran 2022 tarihleri arasında kliniğimizde arı alerjisine bağlı sistemik reaksiyon nedeniyle takipli ve Amerikan Ulusal Alerji ve Enfeksiyon Hastalıkları Enstitüsü (National Institutes of Allergy and Infectious Disease, NIAID) ile Besin Alerjileri ve Anafilaksi Ağı (Food Allergy and Anaphylaxis Network, FAAN) tarafından 2006 yılında geliştirilen ölçütlere göre anafilaksi kriterlerine uyan olgular alındı. Arı türü, bazal triptaz, Total IgE ve venom spesifik IgE düzeyleri, deri testi sonuçları kaydedildi. Anafilaksi şiddeti Mueller kriterlerine göre skorlandı. Ataklarda adrenalin kullanımı, adrenalin otoenjektörü bulundurma değerlendirildi. Bulgular Toplam 102 arı ilişkili anafilaksi olgusundan %53,9’unun erkek olup ortalama yaşın 44.8 olduğu saptandı. Arı türü açısından %69,6 olguda bal arısı (Apidae), %19,6 olguda yaban arısı (Vespidae), %10,8 olguda ise her iki türle anafilaksi geliştiği belirlendi. Anafilaksi şiddeti Mueller sınıflanmasına göre %10,7 olgu Grade I, %58,8 Grade II, %27,45 Grade III, %2,91 ise Grade IV ile uyumluydu. Atak sıklığı açısından 20 olgu tek atak, 37 olgu 2, 42 olgu ise 3 veya daha fazla anafilaksi atağı geçirdiği belirlendi. Hastaların %44,11’inde atopi saptandı. Yaş, cinsiyet, atopik durum, kronik hastalık birlikteliği, ek ilaç kullanımı ve kanda eosinofil, total IgE düzeyleri ile reaksiyon şiddeti arasında anlamlı bir ilişki saptanmadı. Hastaların %80,4’üne adrenalin otoenjektör reçetelenmesine rağmen tedavide adrenalin kullanım oranı %31,4 saptandı. Sonuç Arı venom ilişkili anafilakside olguların çoğu birden fazla atak geçirmesine rağmen tedavide adrenalin kullanım oranları düşük seviyelerde kalmaktadır. En sık anafilaksi bal arısı sokmasına bağlı olarak gelişirken erkek cinsiyette riskin daha fazla olduğu saptandı

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Skin Testing in the Evaluation of Hymenoptera Allergy and Drug Allergy

Cited by 3 publications

References 71 publications

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E₂ pathway

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E₂ pathway

Patients with negative skin tests

Ari Venomuna Bağli Anafi̇laksi̇: Kli̇ni̇k Deneyi̇mi̇mi̇z

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Skin Testing in the Evaluation of Hymenoptera Allergy and Drug Allergy

Cited by 3 publications

References 71 publications

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E2 pathway

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E2 pathway

Patients with negative skin tests

Ari Venomuna Bağli Anafi̇laksi̇: Kli̇ni̇k Deneyi̇mi̇mi̇z

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Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E₂ pathway

Effect of Zhongyi paste on inflammatory pain in mice by regulation of the extracellular regulated protein kinases 1/2–cyclooxygenase-2–prostaglandin E₂ pathway