Skin sodium, lymphatics, and blood pressure: a non-canonical mechanism of salt-sensitive hypertension

Nosalski, Ryszard; Guzik, Tomasz J.

doi:10.1093/eurheartj/ehad290

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Hypertension and Dermal Lymphangiogenesis1

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2023

2024

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Cited by 4 publications

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“…Specifically, impaired lymphangiogenesis and lymphatic dysfunction contribute to sodium and fluid imbalances underlying salt-sensitive hypertension. 38,39 Increasing evidence indicates that the skin and cutaneous lymphatics are important regulators of sodium (Na + ) balance and blood pressure (BP). [40][41][42] With a high-salt diet (HSD), sodium accumulates in the skin, stimulating dermal macrophages to secrete VEGF-C, which activates local lymphangiogenesis.…”

Section: Hypertension and Dermal Lymphangiogenesismentioning

confidence: 99%

Role of Lymphangiogenesis in Cardiac Repair and Regeneration

Xu,

Lu,

Chen

et al. 2023

Methodist DeBakey Cardiovascular Journal

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This article highlights the importance of the structure and function of cardiac lymphatics in cardiovascular diseases and the therapeutic potential of cardiac lymphangiogenesis. Specifically, we explore the innate lymphangiogenic response to damaged cardiac tissue or cardiac injury, derive key findings from regenerative models demonstrating how robust lymphangiogenic responses can be supported to improve cardiac function, and introduce an approach to imaging the structure and function of cardiac lymphatics.

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