Skin Sensitivity of Rheumatic Subjects to Streptococcus Filtrates

Irvine-Jones, E.

doi:10.1001/archinte.1928.00130220148008

Cited by 22 publications

(2 citation statements)

References 11 publications

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“…Secondly, very little is known concerning skin reactivity, in general, to non-specific foreign proteins during or following different diseases. The recent work of Irvine-Jones (11) brings out the fact that persons suffering from rheumatic fever, particularly during the acute stage, are relatively skin-sensitive to the filtrates from various sorts of streptococcic cultures. Whether or not such individuals are sensitive to the filtrates from cultures of other types of bacteria or to protein substances of primarily non-toxic nature remains to be demonstrated.…”

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confidence: 99%

Non-Hemolytic Streptococci and Acute Rheumatic Fever

Nye¹,

Seegal²

1929

Journal of Experimental Medicine

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1. Blood cultures from 25 cases of acute rheumatic fever were negative for non-hemolytic streptococci of both the alpha and gamma types. 2. Non-hemolytic (gamma type) streptococci were frequently recovered from the throats of patients with this disease. 3. Similar organisms were recovered just as frequently from the throats of normal individuals. 4. Although these non-hemolytic streptococci were morphologically and culturally identical, not only amongst themselves, but also when compared with stock Small and Birkhaug strains, all, including the latter, have failed to show any noteworthy degree of homogeneity. 5. Representative strains of these streptococci have proved to be relatively non-pathogenic for rabbits following intravenous injection. 6. These organisms, with a few exceptions, have failed to produce soluble skin-reacting toxins comparable to Birkhaug's standard test toxin. 7. The foregoing facts seem to invalidate the assumption that any of these non-hemolytic streptococci play a specific rôle in the etiology of acute rheumatic fever.

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Non-Hemolytic Streptococci and Acute Rheumatic Fever

Nye¹,

Seegal²

1929

Journal of Experimental Medicine

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“…Birkhaug (6), Kaiser (7), Irvine-Jones (8) and Swift, Wilson and Todd (9) all reported a higher incidence of hypersensitiveness among patients suffering from rheumatic infection than among those with other diseases when tested intracutaneously with filtrates of various strains of streptococci. The last named authors suggested that the reaction is caused by an intracellular toxic substance set free when the organisms autolyze in the culture media rather than by a toxin produced and secreted during their growth.…”

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confidence: 99%