Skin rash on site of application of Dashanga Lepa (polyherbal formulation): A rare and unexpected drug reaction

Ajanal, Manjunath; Kadam, Avinash; Nayak, Shradda U

doi:10.4103/0257-7941.103193

Cited by 6 publications

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References 2 publications

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“…This may be a good example for unpredictable or idiosyncratic reaction because it is very hard to predict cause and effect relation in modern pharmacology or Ayurvedic pharmacology as has been reported in the case of administration of Daśāṅga lepa induced skin rashes[ 7 ] so it may be grouped under type-B type of ADR.…”

Section: Discussionmentioning

confidence: 99%

“…Such as manifestation of skin diseases on external administration of juice of Bhallātaka ( Semecarpus anacardium ),[ 4 ] by suppressing the urge of Chardi (vomiting),[ 5 ] Vamana mithyayoga (inadequate administration of emesis). [ 6 ] There are few recently published ADR reports on Ayurvedic drugs as Daśāṅga lepa (poly-herbal formulation) induced skin rashes[ 7 ] and thyroiditis, followed by ginger consumption. [ 8 ]…”

Section: Introductionmentioning

confidence: 99%

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A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

Ajanal¹,

Prasad²

2014

Ancient Sci Life

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It is a common notion among people in India that herbal or Ayurvedic products are safe and do not produce any adverse effect. This is not true since Ayurveda has evaded many adverse effects which occur by combination of herbs. This axiom is potentiated by our report that occurs in the form of skin rashes. A 20-year-old South Indian female of Pittakapha prakṛti (constitution) after beginning therapy with Aragvādādi kaṣāyam (ARK) (poly-herbal formulation) and Syrup Talekt (poly-herbal patent formulation) for the treatment of recurrent incidence of abscess. Rash disappeared after stopping the suspected drug and treatment with Vibhītakī kaṣāyam (decoction of Terminilia bellarica) and Śatadhauta ghṛtam. Possible and probable (score 6) were the causality according to WHO-Uppsala Monitoring Centre and Naranjo's Adverse Drug Reaction Probability Scale and grouped under type-B reaction. To the best of our knowledge, this is the first case of skin rashes which seen after administration of ARK and Syrup Talekt. This report highlights the need of implementation of pharmacovigilance center in the hospital level and additional research in the field of skin toxicity of ARK and Syrup Talekt.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

Ajanal¹,

Prasad²

2014

Ancient Sci Life

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“…Adverse events reported in relation to herbal products are frequently attributable either to poor quality or to improper use, and it is therefore difficult to distinguish genuine adverse reactions to herbal medicines and herbal products until the cause of such events has been identified (6). There are handfuls of case reports where specific cutaneous adverse effects are documented to be caused by Ayurveda medicines (7,8,9). Till date, the diagnosis of cutaneous adverse drug reactions is purely clinical.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions on application of Nagaradi Lepa - A Retrospective analysis

Kurikkal,

Unnikrishnan,

Narayanan

2024

IJAM

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Introduction: Cutaneous adverse drug reactions are among the most common types of drug hypersensitivity reactions. Although considered natural and safe, Ayurveda medicines can cause adverse reactions. This article highlights the cases of cutaneous adverse drug reactions possibly due to external application of Nagaradi lepa. Materials and Methods: This is an observational, retrospective and record based study conducted by analyzing the spontaneous reported ADR forms, caused by the external application of Nagaradi lepa, collected over a period of 12 months (April 2022 to March 2023) at Peripheral Pharmacovigilance Centre, VPSV Ayurveda College Kottakkal, Kerala. Results: During the period of one year, 3 cutaneous ADRs were reported due to external application of Nagaradi lepa. All the 3 cases fall under the category of Probable according to Naranjo’s ADR Probability scale. 2 cases were mild and 1 case was moderate in severity. All the 3 cases were recovered from ADR. Conclusion: Though under reporting, we may have to consider the possibility of Ayurvedic drugs to cause adverse drug reactions. Pharmacovigilance is an ongoing and continuous process. Reporting of ADR to Pharmacovigilance centers help to generate information on ADR related Ayurvedic formulations and also to prevent its recurrence.

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“…However, there is paucity in adverse drug reaction (ADR) reporting for herbal or ayurvedic drugs to pharmacovigilance authorities. Few studies published have shown that serious adverse reactions may happen due to herbal medicines [2,3,4,5,6]. Ashwagandha (Withania somnifera) is an ayurvedic medicine possesses anti-inflammatory, anti-tumor, anti-stress, antioxidant, immunomodulatory, hemopoietic, and rejuvenating properties [7].…”

Section: Introductionmentioning

confidence: 99%

Ashwagandha-Induced Gastric Upset in Post-Covid Patient-A Case Report and Brief Review of the Literature

Javed

Najmi

2021

JOCAMR

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Adverse drug reporting of herbal drugs is less common as they are generally considered as safe. It is also very common to use self-medication by people in the case of herbal drugs. But many times, mild to severe events have been seen with the use of herbal or ayurvedic medicines. We have reported a case of post-covid patient, who was having complained of headache, body ache, lethargy, backache, generalized weakness and excessive sweating since one weak. Patient had past history of hospitalization due to COVID-19 moderate pneumonia one month back. Patient also had history of type-2 diabetes mellitus, hypertension and dyslipidemia and was taking anti-diabetic and anti-hypertensive medications continuously. Ashwagandha powder (Withania somnifera), Maha yogaraj guggulu (herbal anti-inflammatory) and Syrup Amynity Plus (herbal immune-booster) were prescribed for these complain. Conversely, moderate severity adverse reaction like nausea, vomiting, diarrhea, and abdominal cramps were noted after the intake of suspected drug i.e. ashwagandha powder. Nevertheless, symptoms were relieved after the de-challenge. This shows a temporal relation of the event with the suspected drug. One more possibility of drug-drug interaction in this case cannot be ruled out completely. Causality assessment was done for this adverse event and it was considered as the “probable” category of the adverse event in WHO causality classification.

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Skin rash on site of application of Dashanga Lepa (polyherbal formulation): A rare and unexpected drug reaction

Cited by 6 publications

References 2 publications

A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

A combined administration of Aragvādādi kaṣāyam and Syrup Talekt induced skin rashes

Cutaneous Adverse Drug Reactions on application of Nagaradi Lepa - A Retrospective analysis

Ashwagandha-Induced Gastric Upset in Post-Covid Patient-A Case Report and Brief Review of the Literature

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