Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic

Shariev, Artur; Menounos, Spiro; Laos, Alistair J.; Laxman, Pooja; Lai, Donna; Su, Hua; Zinger, Anna; McRae, Christopher; Casbolt, Llewellyn S.; Combes, Valéry; Smith, Greg; Hung, Tzong-Tyng; Dixon, Katie M.; Thordarson, Pall; Mason, Rebecca; Das, Abhirup

doi:10.1016/j.redox.2020.101790

Cited by 7 publications

(5 citation statements)

References 64 publications

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“…Consistently with the demonstration of SOD as a therapeutic agent for skin diseases, the most recently published data explore a new SOD mimetic, the RM191A: a water-soluble dimeric copper (Cu 2+ -Cu 3+ )-centered polyglycine coordination complex with superoxide quenching activity 10-fold higher than that of SOD. This compound, which is under Phase 2 investigation for the relief of neuropathic pain as a local spray (registration number ACTRN12617000206325; https://www.anzctr.org.au, last accessed on 19 March 2021), was demonstrated to accelerate excisional wound healing, reduce 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation, and attenuate ageassociated oxidative stress in skin when administered to mice as topical gel [216].…”

Section: Skin Diseasesmentioning

confidence: 99%

Superoxide Dismutase Administration: A Review of Proposed Human Uses

et al. 2021

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Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated.

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Section: Skin Diseasesmentioning

confidence: 99%

Superoxide Dismutase Administration: A Review of Proposed Human Uses

et al. 2021

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Section: Discussionmentioning

confidence: 98%

“…SOD content increased at D28 compared to D0 related to boost of antioxidant defense. 23 Decrease of PGE2 at D28 and D84 compared to baseline might be related to decreased erythema based on clinical evaluation. 24 The current investigation on M89PF in addition to tretinoin also demonstrated improved subject's perception of quality of life (QOL) based on the DLQI and Skindex 16.…”

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confidence: 98%

Benefits of the Dermocosmetic Mineral 89 Probiotic Fractions Adjunct to Topical Retinoids for Anti-Aging Benefits

Valpaços¹,

Leclerc‐Mercier²,

Lopes³

et al. 2023

CCID

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Purpose Tretinoin is a topical gold standard for photoaging treatment. However, patient adherence can be impaired by local tolerability in the first 1–2 weeks of treatment. Mineral 89 Probiotic Fractions ® (M89PF) containing Vichy volcanic mineralizing water ® , probiotic fractions, hyaluronic acid, niacinamide and tocopherol was developed to fulfill the need for adjunctive products that can reinforce skin barrier and manage retinoid induced irritation. Patients and Methods The study included 38 women, aged 44–60 years, phototype II–VI, applying 0.025% tretinoin gel once nightly for 84 days. For 28 days, one hemi face was treated with M89PF and sunscreen SPF 50+ while other hemi face received sunscreen only. Then, M89PF application was changed to full face. Evaluations were performed at days 0, 7, 28 and 84. Erythema, dryness, fine lines, skin tone, radiance and pore appearance were assessed by a dermatologist. Tolerability was evaluated through self-assessment questionnaire. Skin hydration levels, inflammatory and oxidative stress biomarkers were analyzed by immunological assay: Interleukin(IL)-8, IL1-alpha, IL1-Receptor Antagonist (IL-1Ra), Prostaglandin E2 (PGE2), Catalase and Superoxide Dismutase (SOD). Results Hemiface analysis showed that erythema, fine lines, skin tone, radiance, pore appearance, hydration, tightness, dryness, burning, itching and stinging sensations were improved (p<0.05) on the M89PF side. At full face analysis on D84, erythema, fine lines, skin tone, radiance and pore appearance were improved compared to D0 (p<0.001). Tightness, dryness, burning, itching and stinging were reduced when compared to D7 (p<0.05). Dermatology Life Quality Index (DLQI) and Skindex 16 showed improvement in quality of life (p<0.05). IL-1RA increased at D28 (p=0.003) and PGE2 decreased at D28 and D84 compared to D0 (p<0.01). Conclusion M89PF reduced retinoid induced irritation with a good tolerability profile and, used as an adjunct to topical tretinoin, significantly improved skin hydration, erythema, fine lines, skin tone, radiance and pore appearance.

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“…According to these results, transfersome and protransfersome are able to improve the solubility and permeability of active cosmetic ingredients with low water solubility and poor permeability, such as Kinetin [133,134], and Superoxide Dismutase, which has also large molecular weight of 30 kDa [135]. Their ability to entrap hydrophobic molecules within the lipid domain of the bilayer membrane as well as the amphiplic properties of the phospholipids used in transfersomes significantly improve the solubility and permeability of such compounds, rendering them useful in delivering active cosmetic ingredients.…”

Section: Transfersomes Act As Encapsulating Carriers For Various Acti...mentioning

confidence: 98%

Ultradeformable Vesicles: Concepts and Applications Relating to the Delivery of Skin Cosmetics

2021

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Skin aging is a phenomenon resulting in reduced self-confidence, thus becoming a major factor in social determinants of health. The use of active cosmetic ingredients can help prevent skin aging. Transfersomes are well known to be capable of deeply penetrating the dermis. This scoping review provides an insight into transfersomes and their prospective use in anti-aging cosmetics. Numerous reports exist highlighting the successful skin delivery of therapeutic agents such as high-molecular-weight, poorly water soluble and poorly permeable active ingredients by means of transfersomes. Moreover, in vitro and in vivo studies have indicated that transfersomes increase the deposition, penetration and efficacy of active ingredients. However, the use of transfersomes in the delivery of active cosmetic ingredients is limited. Considering their similar physicochemical properties, transfersomes should possess considerable potential as a delivery system for anti-aging cosmetics.

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Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic

Cited by 7 publications

References 64 publications

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Benefits of the Dermocosmetic Mineral 89 Probiotic Fractions Adjunct to Topical Retinoids for Anti-Aging Benefits

Ultradeformable Vesicles: Concepts and Applications Relating to the Delivery of Skin Cosmetics

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