Skin pH: From Basic SciencE to Basic Skin Care

Abstract

The "acid mantle" is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and finally discuss practical application for preservation of the acid mantle. Recognizing factors that alter skin pH and selecting products that preserve the acid mantle is of prime importance in treating dermatologic patients.

The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits

“…Most reports have suggested that a pH between 4 and 6.5 can be considered as adequate for cosmetic formulations since most pathogenic bacteria (e.g. S. aureus), thrive best at neutral pH levels (Ali and Yosipovitch, 2013). In the present work, the cosmeceutical formulation presented a pH 4.6, which is considered within the favourable pH range.…”

“…The rate of dermal absorption of topical formulations such as lotions and creams are often influenced by the pH of the product. The pH of skin external surface is around 5.5, and at this condition, the skin micro-flora, barrier homeostasis and stratum corneum are maintained (Ali and Yosipovitch, 2013;Martínez-Pla et al, 2004). Most reports have suggested that a pH between 4 and 6.5 can be considered as adequate for cosmetic formulations since most pathogenic bacteria (e.g.…”

What is the pH, Fe and Cl2 content of cosmetics we use? – a pilot study on safety of skin care products

“…A cosmetic is any substance or preparation intended for external contact with the human body: skin, hair, lips, nails, external genital organs, teeth and mucous membranes oral, and its sole or primary purpose is to maintain cleanliness of these body parts, to improve appearance of the body or improve its smell [4].…”

PH value of the base of topical drug product: the choice of the optimal value and the role of buffer system

“…-активность ферментов β-глюкоцереброзидазы и кислой сфингомиелиназы -ключевых ферментов, участвующих в регуляции проницаемости кожи [10];…”

“…Это является причиной выраженно-го градиента рН (2-3 ед.) между рН рогового слоя и рН эпидермиса и дермы [10]. Повышение уровня рН способствует росту активности сериновой протеа-зы, калликреина 5 и 7, которые участвуют в десква-мации и деградации корнеодесмосом [17].…”