Skin pH–dependent <i>Staphylococcus aureus</i> abundance as predictor for increasing atopic dermatitis severity

Hülpüsch, Claudia; Tremmel, Karolina; Hammel, Gertrud; Bhattacharyya, Madhumita; Tomassi, Amedeo de; Nußbaumer, Thomas; Neumann, Avidan U.; Reiger, Matthias; Traidl‐Hoffmann, Claudia

doi:10.1111/all.14461

Cited by 54 publications

(68 citation statements)

References 51 publications

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“…80 Thus, resolving the enigma of skin-microbe interaction as a function of skin homeostasis has to take more players into the sight. 81 In conclusion, skin bacterial microbiome shows great potential to be used as a clinically important biomarker for atopic eczema. To reach this aim, we need to perform prospective clinical trials and large longitudinal registries that include skin microbiome testing.…”

Section: S K In Bac Terial MI Crob I Ome a S Clini C Al B I Omark Ementioning

confidence: 94%

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Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder

Peng

Agache

et al. 2020

Allergy

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161

150

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Section: S K In Bac Terial MI Crob I Ome a S Clini C Al B I Omark Ementioning

confidence: 94%

“…Recently, biofilm propensity of S aureus skin isolates as a cause and possible target has become more and more of a central issue 80 . Thus, resolving the enigma of skin–microbe interaction as a function of skin homeostasis has to take more players into the sight 81 …”

Section: Skin Bacterial Microbiome As Clinical Biomarker In Atopic Ecmentioning

confidence: 99%

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder

Peng

Agache

et al. 2020

Allergy

Self Cite

161

150

View full text Add to dashboard Cite

show abstract

“…74 Thus, resolving the enigma of skin-microbe interaction as a function of skin homeostasis has to take more players into the. 75 In conclusion, skin bacterial microbiome shows great potential to be used as a clinically important biomarker for atopic eczema. To reach this aim, we need to perform prospective clinical trials and large longitudinal registries that include skin microbiome testing.…”

Section: Skin Bacterial Microbiome As Clinical Biomarker In Atopic Ecmentioning

confidence: 94%

Biomarkers in the Diagnosis and Therapy of Allergic Diseases and Asthma

Breiteneder¹,

Peng²,

Agache³

et al. 2020

Preprint

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Modern healthcare requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of the distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions on the efficacy of the current management of allergic diseases requires further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen-immunotherapy with a special emphasis on specific IgE, microbiome and epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.

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“…The exact lipid composition can then be identified by downstream analyses such as mass spectrometry to provide information on disease‐specific lipid alterations 74 . The pH level is another parameter of the skin barrier and is increased in situations of infection 75 …”

Section: Noninvasive and Minimally Invasive Diagnostics Of Skin Diseasesmentioning

confidence: 99%

Noninvasive and minimally invasive techniques for the diagnosis and management of allergic diseases

Baumann

Untersmayr

Zissler

et al. 2021

Allergy

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Allergic diseases of the (upper and lower) airways, the skin and the gastrointestinal tract, are on the rise, resulting in impaired quality of life, decreased productivity, and increased healthcare costs. As allergic diseases are mostly tissue‐specific, local sampling methods for respective biomarkers offer the potential for increased sensitivity and specificity. Additionally, local sampling using noninvasive or minimally invasive methods can be cost‐effective and well tolerated, which may even be suitable for primary or home care sampling. Non‐ or minimally invasive local sampling and diagnostics may enable a more thorough endotyping, may help to avoid under‐ or overdiagnosis, and may provide the possibility to approach precision prevention, due to early diagnosis of these local diseases even before they get systemically manifested and detectable. At the same time, dried blood samples may help to facilitate minimal‐invasive primary or home care sampling for classical systemic diagnostic approaches. This EAACI position paper contains a thorough review of the various technologies in allergy diagnosis available on the market, which analytes or biomarkers are employed, and which samples or matrices can be used. Based on this assessment, EAACI position is to drive these developments to efficiently identify allergy and possibly later also viral epidemics and take advantage of comprehensive knowledge to initiate preventions and treatments.

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Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity

Cited by 54 publications

References 51 publications

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Biomarkers in the Diagnosis and Therapy of Allergic Diseases and Asthma

Noninvasive and minimally invasive techniques for the diagnosis and management of allergic diseases

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