Skin penetration of topically applied products: quantitative in vivo analysis by Raman spectroscopy (Conference Presentation)

Puppels, Gerwin J.; Nico, C.; Schut, Tom C. Bakker; Sterke, Johanna de

doi:10.1117/12.2544381

Cited by 1 publication

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“…This non‐destructive, label free and reagent (solvent) free technique provides molecular fingerprints based on the intrinsic, inelastic scattering of light, when the sample is illuminated with a laser source without adding any tracer. Moreover, coupling the molecular specificity of the analysis with the micrometric spatial resolution offers a relevant platform for evaluation of local diffusion and distribution of active molecules [3–9].…”

Section: Introductionmentioning

confidence: 99%

Raman mapping coupled to self‐modelling MCR‐ALS analysis to estimate active cosmetic ingredient penetration profile in skin

Stella

Bonnier

Tfayli³

et al. 2020

Journal of Biophotonics

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Confocal Raman mapping (CRM) is a powerful, label free, nondestructive tool, enabling molecular characterization of human skin with applications in the dermo-cosmetic field. Coupling CRM to multivariate analysis can be used to monitor the penetration and permeation of active cosmetic ingredients (ACI) after topical application. It is presently illustrated how multivariate curve resolution alternating least squares (MCR-ALS) can be applied to detect and semi-quantitatively describe the diffusion profile of Delipidol, a commercially available slimming ACI, from Raman spectral maps. Although the analysis outcome can be critically dependent on the a priori selection of the number of regression components, it is demonstrated that profiling of the kinetics of diffusion into the skin can be established with or without additionnal spectral equality constraints in the multivariate analysis, with similar results. Ultimately, MCR-ALS, applied without spectral equality contraints, specifically identifies the ACI as one of main spectral components enabling to investigate its distribution and penetration into the stratum corneum and underlying epidermis layers.

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Section: Introductionmentioning

confidence: 99%