Skin penetration and retention of L-Ascorbic acid 2-phosphate using multilamellar vesicles

Yoo, Juno; Shanmugam, Sumathi; Song, Chung-Kil; Kim, Dae‐Duk; Choi, Hyun Seok; Yong, Chul-Soon; Woo, Jong-Soo; Yoo, Bong Kyu

doi:10.1007/s12272-001-2164-4

Cited by 22 publications

(14 citation statements)

References 12 publications

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“…Figure 1 also shows the comparison of negatively (LPKO) and positively charged vesicles (LPKO-SA). SC contains a high amount of negatively charged lipids, thus by having the same charge as the skin, negatively charged vesicle can increase the possibility of drug absorption or penetration into the skin (Sinico et al, 2005;Yoo et al, 2008). However, depending on drug type, negatively or positively charged vesicles were able to increase the accumulation or penetration of the drug (Katahira et al, 1999;Ogiso et al, 2001;Sinico et al, 2005;Song and Kim, 2006).…”

Section: Ve Retention In Skin Layersmentioning

confidence: 99%

Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug

Aripin

Hashim

Heidelberg

et al. 2012

Journal of Microencapsulation

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Disaccharide glycosides synthesised from food grade resources consist of the hydrophilic head group of maltose or lactose and provide better hydrophilic-lipophilic balance (HLB = 12) to the long alkyl chain derived from palm oil (PO) and palm kernel oil (PKO). Maltoside provides more flexibility in the vesicle's membrane because of its low packing density in the bilayer membrane compared to lactoside. The bending of the molecular structure in maltose form a less compact assembly for maltoside, whereas lactose is more linear in shape. Apart from hydrophilic moieties, packing behaviour was also governed by the hydrophobic moieties. PO has higher degree of unsaturation compared to PKO, thus providing higher fluidity in the bilayer membrane. Vesicle with high membrane flexibility is easier to disintegrate and deform to enhance drug penetration into the skin. Results showed that the glycosides delivered vitamin E (VE) into deeper skin layer at least two-fold higher than free VE.

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Section: Ve Retention In Skin Layersmentioning

confidence: 99%

Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug

Aripin

Hashim

Heidelberg

et al. 2012

Journal of Microencapsulation

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“…The skin homogenate was filtered through a 0.22 μm cellulose acetate membrane to obtain a clear solution. The amount of IMC in the clear solution was then determined for IMC retained in the skin (31). The formulation that remained in the donor compartment after the permeation study was dissolved in methanol and adjusted to 25 mL in a volumetric flask.…”

Section: In Vitro Permeation and Skin Experimentsmentioning

confidence: 99%

Physicochemical Performances of Indomethacin in Cholesteryl Cetyl Carbonate Liquid Crystal as a Transdermal Dosage

et al. 2012

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Abstract. A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC-CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1-5 %) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12 h. A low amount of IMC in 1 % IMC-CCC permeated the stratum corneum. Further formulation development has been carried out by the addition of lauryl alcohol into 5 % IMC-CCC mixture it was found that the permeation of IMC was significantly improved to 45 % within 24 h.

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“…Two types of AP salts, sodium and magnesium, have been used to explore ways to improve skin penetration using several enhancing methods [6,7]. Iontophoresis has been investigated as a way to enhance skin penetration since an AP salt molecule includes 2 -3 anions [6,8].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Iontophoretic Delivery of Magnesium Ascorbyl 2-Phosphate and Sodium Fluorescein to Hairless and Hairy Mouse Skin

Kang¹,

Kim²,

Sung³

et al. 2012

JCDSA

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We recently reported that L-ascorbic acid 2-phosphate (AP) stimulates the growth of human dermal papilla (DP) cells, induces secretion of IGF-1 from the DP cells to promote hair shafts elongation in cultured human hair follicles, and triggers early progression from the telogen to anagen phase in mice. Since the magnesium salt of AP (APMg) is a highly hydrophilic ionic molecule, it is not easy to deliver this reagent to the skin or hair follicles by topical application alone. In order to enhance skin penetration of APMg without changing any molecular properties, a non-invasive iontophoretic delivery method was introduced. Iontophoresis of the negatively charged APMg under the electrode bearing same charge (cathode) significantly enhanced the in vitro penetration of APMg into a Franz cell equipped with mouse dorsal skin. In contrast, iontophoretic movement with the anode inhibited APMg penetration achieved with passive diffusion alone. The effect of iontophoresis on enhancing the penetration of APMg was also found to be much higher in the skin of hairy mice (3 -8 times) compared to hairless mice (1.5 -2.5 times). These findings indicated that iontophoretic movement induced the transfollicular pathway more strongly and effectively than the transdermal pathway. This phenomena was also demonstrated by the in vivo iontophoretic delivery of sodium fluorescein using hairy and hairless mice. The degree of iontophoretic enhancement during APMg penetration was also dependent on various conditions such as current density and application duration.

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Skin penetration and retention of L-Ascorbic acid 2-phosphate using multilamellar vesicles

Cited by 22 publications

References 12 publications

Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug

Effect of vesicle's membrane packing behaviour on skin penetration of model lipophilic drug

Physicochemical Performances of Indomethacin in Cholesteryl Cetyl Carbonate Liquid Crystal as a Transdermal Dosage

Enhanced Iontophoretic Delivery of Magnesium Ascorbyl 2-Phosphate and Sodium Fluorescein to Hairless and Hairy Mouse Skin

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