Skin microcirculation in patients with arterial hypertension and in patients with a combination of arterial hypertension and type II diabetes mellitus

Васильев, А. П.; Streltsova, N. N.

doi:10.24884/1682-6655-2020-19-4-44-52

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Параметры микроциркуляции (МКЦ) подробно изучались у больных с артериальной гипертензией [9][10], ишемической болезнью сердца (ИБС) [11] и сахарным диабетом [12]. Имеются отдельные исследования, посвященные изучению микрососудистой дисфункции при ХСН [13,14], однако до настоящего времени вклад различных компонентов регуляции МКЦ в патогенез ХСН до конца не изучен, как не установлены и взаимосвязи показателей МКЦ (ПМ) и параметров внутрисердечной гемодинамики, что определило цель настоящего исследования -изучить взаимосвязи основных параметров МКЦ и внутрисердечной гемодинамики у пациентов с ХСН.…”

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Skin microcirculation in patients with heart failure with different left ventricular systolic dysfunction

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Dragomiretskaya

Beliaev

et al. 2021

Cardiovasc Ther Prev

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Aim. To study the relationship of mechanisms of microcirculation regulation and intracardiac hemodynamics in patients with heart failure (HF).Material and methods. In eighty patients with NYHA class II-IV HF, microcirculation was assessed by laser Doppler flowmetry and intracardiac hemodynamics — by echocardiography.Results. The patients were divided into 3 groups depending on HF type: with preserved ejection fraction (CHpEF) (>50%) — 27 patients, mid-range EF (CHmrEF) (40-50%) — 25 patients, reduced EF (CHrEF) (<40%) — 28 patients. Comparative analysis revealed a significant decrease in the coefficient of variation (CV) in all groups without microcirculation differences. The greatest number of significant correlations was found between the myogenic component of microcirculation frequency range and the following echocardiographic parameters: left ventricular EF (r=0,351, p<0,05); end-diastolic dimension (r=-0,492, p<0,05), end-systolic dimension (r=-0,474, p<0,05), end-diastolic volume (r=-0,544, p<0,05), end-systolic volume (r=-0,449, p<0,05), etc.Conclusion. In patients, regardless of left ventricular EF, satisfactory perfusion was obtained, which is achieved due to inhibition of active mechanisms and compensatory activation of passive mechanisms of microcirculation regulation. The relationship between the development of myocardial remodeling and microcirculatory dysfunction is noted.

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Section: Introductionunclassified

Skin microcirculation in patients with heart failure with different left ventricular systolic dysfunction

Подзолков

Dragomiretskaya

Beliaev

et al. 2021

Cardiovasc Ther Prev

View full text Add to dashboard Cite

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Functional state of skin microvascular bed according to laser doppler flowmetry in patients with arterial hypertension combined with hypercholesterolemia

Streltsova

Vasilyev

2022

Regional blood circulation and microcirculation

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Introduction. The great importance of risk factors, such as arterial hypertension (AH) and low-density lipoprotein cholesterol (LDL-H), for development of cardiovascular diseases, makes highly relevant to obtain the data of the nature of microcirculation (MC) changes that are a key link of maintaining homeostasis under their concomitant influence. Aim – to evaluate functional state of skin microvascular bed using laser Doppler flowmetry in patients with arterial hypertension (AH) and combined with hypercholesterolemia. Materials and Methods. The study involved 37 practically healthy volunteers and 94 patients with 2–3 stage of AH, which were divided into 2 groups: Gr.1 with LDL-CH level ≤3.5 mmol/l (n = 35) and Gr.2 with LDL-H level >3.5 mmol/l (n = 59). MC of the forearm skin was assessed by laser Doppler flowmetry. Parameters of basal blood flow, the amplitude-frequency spectrum of its fluctuations, nutritional MC, and parameters of occlusion test were evaluated. Results. Analyzing rhythm structure of blood flow fluctuations, statistically significant decrease in standardized parameters of their amplitude in endothelial and myogenic frequency ranges was revealed in patients with elevated LDL-CH levels compared to patients of Gr.1 by 19.7 % and 9.7 % (р = 0.045), respectively, which indicated weakening of endothelial function and constriction of precapillary segment of MC. These changes were accompanied by decrease in reserve of microvascular blood flow by 9.1 % in Gr.2 of patients (p = 0.044) with pronounced trend towards reduction of capillary perfusion and activation of blood flow through arteriolovenular shunts. Conclusion. More pronounced functional disorders of MC, characterized by endothelial dysfunction, constriction of precapillary segment, and decrease in reserve potential of tissue hemoperfusion were revealed in AH patients with atherogenic hyperlipidemia vs AH patients.

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Study of the response of the microvascular bed to oxygen-helium therapy using high-frequency Doppler ultrasound in patients with COVID-19

Skedina

Kovaleva

Manuilov

2023

Regional blood circulation and microcirculation

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Introduction. For the treatment of patients with hypoxemic form of respiratory failure, thermal oxygen-helium mixture (OHM) therapy is used.The aim of the work is to study the effect of OHM on the state of the microcirculatory bed in viral pneumonia caused by COVID-19 in patients with aggravated and unaggravated anamnesis.Materials and methods. There were 8 patients with an uncomplicated anamnesis, 11 with AH1–2 degree, 11 with AH1–2 degree and type II diabetes. The parameters of blood flow in the MVB were recorded with an ultrasound dopplerograph. OHM therapy (O2 – 30 %, He – 70 %, t=+95 ºС): 5 min breathing, 5 min rest – 3 cycles.Results. Before the OHM therapy, the level of «basic perfusion» was increased in group 3: significantly high Vs (p=0.02) and Vd (p=0.006), low RI (p=0.015) relative to group 1, this indicates a reduced vascular tone and venous congestion. After the OHM session in patients of group 1, the speed of Vs and Vd increased, the indices RI and PI decreased. In group 2 – Vs, Vd and Vam increased, RI decreased. The effect is long lasting. In group 3, the effect was noted on day 5, short-term. Conclusions. OHM therapy has a positive effect.

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Skin microcirculation in patients with arterial hypertension and in patients with a combination of arterial hypertension and type II diabetes mellitus

Cited by 3 publications

References 15 publications

Skin microcirculation in patients with heart failure with different left ventricular systolic dysfunction

Skin microcirculation in patients with heart failure with different left ventricular systolic dysfunction

Functional state of skin microvascular bed according to laser doppler flowmetry in patients with arterial hypertension combined with hypercholesterolemia

Study of the response of the microvascular bed to oxygen-helium therapy using high-frequency Doppler ultrasound in patients with COVID-19

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