Skin metastases of cervical cancer: two case reports and review of the literature

Abstract

BackgroundAlthough cervix carcinoma is one of the most common malignancies in women, hematogenous metastases are relatively not common. Cutaneous metastases, in particular, are unusual even at an advanced stage of disease. Their presence is a predictor of poor prognosis.Case presentationCase 1: A 63-year-old postmenopausal Moroccan woman was diagnosed as having cervical squamous cell carcinoma. She was treated with radical concurrent chemotherapy and radiation therapy followed by low-dose brachytherapy. Six months after finishing the therapy, multiple skin nodules appeared on her abdomen and chest wall. An excision biopsy was performed and showed metastatic squamous cell carcinoma. Her disease progressed and she died before completing her fourth course of palliative chemotherapy.Case 2: A 48-year-old Moroccan woman was diagnosed as having cervical squamous cell carcinoma; she was treated with concurrent chemoradiation. Before a planned high-dose brachytherapy, she noticed many nodular lesions on her arms, thighs, and chest wall. An excision biopsy was performed and showed metastatic squamous cell carcinoma. She then underwent a series of imaging examinations, including computed tomography of her chest, abdomen, and pelvis, and a whole body bone scan that showed disseminated disease involving her lungs and bones. She died after two courses of palliative chemotherapy, 2 months after the appearance of the skin lesions.ConclusionWe report two cases to illustrate a rare localization of metastasis from cervical carcinoma that is highly aggressive requiring early detection and aggressive management.

Cancer Cervix With Skin Metastasis - A Case Report With Review of Literature

“…The manifestation in the upper extremities is still rarer. Only six cases have been reported in the upper extremity and after best literature search, our case is first to report in [5][6][7] the forearm region.…”

“…Out of the 329 patients of cancer cervix treated at our centre in last 9 years, this is the first case of skin relapse 10 months after radiotherapy with no evidence of associated locoregional failure, the reported incidence is 0.3%.To the best of our knowledge, only six cases of carcinoma cervix metastasizing to upper extremity have been reported all over the world and this is the first case reported to have [5][6][7] cutaneous manifestation in the forearm region.…”

Vulvar Metastases from Colorectal and Gynecological Tumors: Two Case Reports and A Literature Review

“…The two cases included in this report involved single nodular lesions. Differential diagnoses included benign dermatitis, mycosis fungoides and Kaposi's sarcoma [6]. Diagnosis is reached by histopathology, with immunohistochemistry providing further information on the case.…”

“…In cases of metastatic cervical cancer, for example, only 20% of patients survive for more than one year. In cases of endometrial cancer with skin metastasis, the mean survival time is 3-6 months, with mortality rates of over 70% in the first year after diagnosis [6]. In the majority of cases, the time between diagnosis of the primary gynecological cancer and the development of skin metastasis is four years [9].…”

Vulvar Metastasis of Cervical Squamous Cell Carcinoma

“…The diagnosis can be challenging, mimicking many skin conditions, and usually it is a strong predictive of poor prognosis. [1][2][3][4] …”