Skin metastases in an area of radiation dermatitis

Marley, N. F.

doi:10.1001/archderm.118.2.129

Cited by 8 publications

(8 citation statements)

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“…Acute and chronic changes may occur in the skin that has been radiated. In addition, benign and malignant neoplasms have been observed in the areas that have received radiotherapy 11–30 (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Malignant neoplasms localized to radiotherapy fields include non‐melanoma skin cancer, melanoma, leukemia/lymphoma, sarcoma and metastatic carcinoma – most commonly breast cancer 16–30 . The development of basal cell or squamous cell carcinoma in radiated skin is a late consequence that typically presents many years after the radiation treatment has been performed 16,23,25,28 .…”

Section: Discussionmentioning

confidence: 99%

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Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient‐report and review of cutaneous neoplasms developing at the site of radiotherapy

Cohen

Prieto

2010

J Cutan Pathol

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Xanthogranulomas are benign lesions composed of macrophages in which some of the cells have vacuolated cytoplasm. They commonly occur in children, referred to as juvenile xanthogranulomata, and are histopathologically characterized by the presence of Touton giant cells. Xanthogranuloma can also occur in adults. A woman who developed a solitary xanthogranuloma within the field of radiotherapy following treatment of her breast cancer is reported. In addition to xanthogranuloma, other benign lesions of keratinocytes, mast cells, endothelial cells and lymphatic cells have been observed at the site of radiation treatment. Also, several malignancies, including hematopoietic cancers, sarcomas, metastatic cancers and common skin cancers, have been observed within radiation ports. A causal relationship in the development of our patient's xanthogranuloma is suggested by the temporal association between the treatment with radiotherapy and the subsequent appearance of a xanthogranuloma directly within the radiation field.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient‐report and review of cutaneous neoplasms developing at the site of radiotherapy

Cohen

Prieto

2010

J Cutan Pathol

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“…Anderson et al (41) demonstrated that local control failures after radiation therapy of cervix cancer was associated with increased distant metastasis. In addition, some investigators reported that metastasis occasionally appeared initially or preferentially in previously irradiated tissue in a various of tumors, such as melanoma (42), nasopharynx carcinoma (43), breast carcinoma (40), and uterine carcinoma (44).…”

Section: Discussionmentioning

confidence: 99%

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

et al. 2004

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Radiotherapy represents a major treatment option for patients with pancreatic cancer, but recent evidence suggests that radiation can promote invasion and metastasis of cancer cells. Interactions between cancer cells and surrounding stromal cells may play an important role in aggressive tumor progression. In the present study, we investigated the invasive phenotype of pancreatic cancer cells in response to coculture with irradiated fibroblasts. Using in vitro invasion assay, we demonstrated that coculture with nonirradiated fibroblasts significantly increased the invasive ability of pancreatic cancer cells and, surprisingly, the increased invasiveness was further accelerated when they were cocultured with irradiated fibroblasts. The hepatocyte growth factor (HGF) secretion from fibroblasts remained unchanged after irradiation, whereas exposure of pancreatic cancer cells to supernatant from irradiated fibroblasts resulted in increased phosphorylation of c-Met (HGF receptor) and mitogen-activated protein kinase activity, possibly or partially via increased expression of c-Met. We also demonstrated that scattering of pancreatic cancer cells was accelerated by the supernatant from irradiated fibroblasts. The enhanced invasiveness of pancreatic cancer cells induced by coculture with irradiated fibroblasts was completely blocked by NK4, a specific antagonist of HGF. These data suggest that invasive potential of certain pancreatic cancer cells is enhanced by soluble mediator(s) released from irradiated fibroblasts possibly through up-regulation of c-Met expression/phosphorylation and mitogen-activated protein kinase activity in pancreatic cancer cells. Our present findings further support the potential use of NK4 during radiotherapy for patients with pancreatic cancer.

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“…Radiotherapy can also induce a local pro-invasive effect, as shown predominantly in breast cancer but also in nasopharyngeal and endometrial cancer, in which inflammatory skin recurrence, exactly demarcating the previously irradiated area, occurred (Tsujino et al, 2011 ; Meltzer et al, 1981 ; Marley & Marley, 1982 ). This phenomenon is rare and its incidence in breast cancer is estimated at 0.25%.…”

Section: Main Textmentioning

confidence: 99%

Effects of radiation on the metastatic process

Sundahl

Duprez

Ost

et al. 2018

Mol Med

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Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. Nonetheless, pre-clinical evidence indicates that radiation can entail pro-metastatic effects via multiple pathways. Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. However, the data remains ambiguous and clinical observations that unequivocally prove these findings are lacking. In this review we discuss the pre-clinical and clinical data on the local and systemic effect of irradiation on the metastatic process with an emphasis on the molecular pathways involved.

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Skin metastases in an area of radiation dermatitis

Cited by 8 publications

References 0 publications

Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient‐report and review of cutaneous neoplasms developing at the site of radiotherapy

Radiation port xanthogranuloma: solitary xanthogranuloma occurring within the irradiated skin of a breast cancer patient‐report and review of cutaneous neoplasms developing at the site of radiotherapy

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

Effects of radiation on the metastatic process

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