Skin metastases confined to a field of previous irradiation: Report of two cases and review of the literature

Abstract

Two cases of tumor recurrence within a previously irradiated skin area are reported. Typical lesions evolve from an erythematous base and progress to induration and tumor papules. A review of clinical literature indicates that irradiation does not increase the frequency of metastases. Experimental data suggest that irradiation does increase metastases as a result of both local mechanical factors and increased tumor‐cell survival.

Cancer Cervix With Skin Metastasis - A Case Report With Review of Literature

“…To date, no effective treatment has been identified. Treatment is nearly always palliative, and consists of using radiation, chemotherapy, or surgery, either alone or in 12,13 combination.…”

Radiation port cutaneous metastases: Reports of two patients whose recurrent visceral cancers presented as skin lesions at the site of previous radiation and literature review

“…[3] We performed an extensive review of the literature available on PubMed using the following search criteria: Cutaneous or skin, metastasis or metastases, radiation or irradiation, and not melanoma or sarcoma or basal cell. We excluded patients who developed melanoma or other primary skin cancers within their radiation port.…”

“…[38] Finally, others postulate that radiation-induced damage to endothelial cells leads to trapping of tumor cells and enhances the occurrence of metastasis. [3] Studies done in animals have demonstrated increased metastasis in tissue that was previously irradiated. [3]…”

“…[3] Studies done in animals have demonstrated increased metastasis in tissue that was previously irradiated. [3]…”

“…[2] Radiation typically affects the skin within the radiation port; however, it is rare for the primary cancer to metastasize within the irradiated skin. [34567891011121314151617171819202122] We describe two patients who developed cutaneous metastases in the area previously irradiated for treatment of their primary malignancies. Additionally, we summarize the characteristics of other patients who developed cutaneous metastases within their radiation ports.…”