Skin Metastases: An Unusual Presenting Sign of Gastric Carcinoma

Kostandy, Gamil; Katapadi, M.; Pullarkat, Vinod; Manzi, Giovanna; Salama, Samih; Sosler, B.; Hussain, K. M. A.

doi:10.1097/00004836-199610000-00018

Cited by 9 publications

(5 citation statements)

References 5 publications

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“… 2 Rarely, inflammatory and sclerodermoid lesions have also been also reported, 3 predominantly originating from adenocarcinomas of the pulmonary, gastrointestinal, genitourinary and oropharyngeal system, the thyroid and the prostate gland. 4–13 In men, cutaneous metastases mainly derive from carcinoma of the lung, the gastrointestinal system and the oropharynx, whereas skin metastases in women originate predominantly from carcinomas of the breast, the colon, the lung or the ovary 14–16 ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Cerebriform nodular amelanotic metastases of malignant melanoma: a challenge in differential diagnosis of a rare variant

Assmann

Farthmann

Burkhardt

et al. 2000

British Journal of Dermatology

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High variability of the clinical appearance of malignant melanoma (MM) and its metastases render the differential diagnosis of solid amelanotic tumours difficult. We report a 71-year-old woman with several unusual cutaneous tumours of cerebriform morphology, suggesting skin metastases from occult internal cancer. Histopathological findings and thorough investigations, however, revealed a late-stage metastatic MM. We discuss the differential diagnosis of skin metastases of various origin and underline the difficulties for early detection of MM.

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Section: Discussionmentioning

confidence: 99%

Cerebriform nodular amelanotic metastases of malignant melanoma: a challenge in differential diagnosis of a rare variant

Assmann

Farthmann

Burkhardt

et al. 2000

British Journal of Dermatology

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“…In very rare cases, skin metastasis may occur at the same time or before the primary cancer has been discovered and may be the prompt for further thorough investigation. Skin metastasis occurs when cancerous cells break away from the primary tumour and make their way to the skin through the blood circulation or lymphatic system [2]. Clinically, they may manifest as firm, subcutaneous or intradermal nodules that are flesh-colored, red, or blue.…”

Section: Discussionmentioning

confidence: 99%

“…Debridement can be done if lesions bleed or crust. Other therapies that may be helpful include [2,3].…”

Section: Treatmentmentioning

confidence: 99%

Cutaneous Manifestation As Primary Manifestation of Carcinoma Stomach

Sekhar,

Voleti,

Joshi

et al. 2006

Apollo Medicine

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“…2 Very few references of cutaneous gastric tumor metastases were found in the reviewed literature. [3][4][5][6][7] Multiple subcutaneous nodules on the trunk seem to be the most common pattern of such metastases. 3,4,7,8 Their histologic features are mainly that of an adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7] Multiple subcutaneous nodules on the trunk seem to be the most common pattern of such metastases. 3,4,7,8 Their histologic features are mainly that of an adenocarcinoma. 8 Solitary nodule presentation, as in our case, may lead to multiple differential diagnoses, such as cutaneous lymphomas or another skin cancer.…”

Section: Discussionmentioning

confidence: 99%

Metastatic gastric cancer presenting as a solitary axillary cutaneous nodule

et al. 2002

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An 84‐year‐old man, with a medical history of dilated cardiomyopathy, was admitted to our hospital with a nodular lesion in his right axilla of 6 weeks’ duration. There was no history of weight loss, nausea, or vomiting. Physical examination revealed a red–violet axillary nodule, 7 cm in diameter and 3 cm thick, with an ulcerated surface (Fig. 1). A palpable right adenopathy was also found. The rest of the physical examination was normal. 1 Cutaneous nodule located on the right axilla A metastatic tumor from an unknown origin was suspected. A biopsy of the cutaneous nodule was performed. Hematoxylin and eosin staining revealed a round and well‐defined nodule, located in the dermis. The nodule was composed of solid nests of atypical cells, with large nuclei and scanty cytoplasm, which tended to form a pseudoglandular pattern (Fig. 2). Atypical mitotic figures were frequently seen. Immunohistochemical examination of the tumoral cells showed a positive reaction with carcinoembryonic antigen and cytokeratin KL1 and a negative reaction with antileukocyte antibody. 2 Tumoral cells with pseudoglandular pattern (hematoxylin and eosin stain, ×40) With these histologic findings, a diagnosis of cutaneous metastasis was made. Blood laboratory evaluation revealed an elevated erythrocyte sedimentation rate (43 mm/h). Tumor markers, including α‐fetoprotein, carcinoembryonic antigen, prostate‐specific antigen, squamous cell carcinoma antigen, and carbohydrate antigen 19–9, were all within normal limits. A chest X‐ray film was normal and an occult blood test was also negative. Neck and chest computed tomography scan identified some adenopathies located on the neck and the right axilla. Barium studies showed an intramural mass lesion in the minor curvature of the stomach. An upper gastrointestinal tract endoscopy showed a submucosal nodule in the cardia. Biopsy of this gastric nodule demonstrated a poorly differentiated carcinoma. Biopsy of both cervical and axillar lymph nodes was performed and no tumoral cells were found. Abdominal–pelvic computed tomography scan and bone scintigraphy showed no pathologic findings. Although supportive chemotherapy was performed, the patient died 6 months later.

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Skin Metastases: An Unusual Presenting Sign of Gastric Carcinoma

Cited by 9 publications

References 5 publications

Cerebriform nodular amelanotic metastases of malignant melanoma: a challenge in differential diagnosis of a rare variant

Cerebriform nodular amelanotic metastases of malignant melanoma: a challenge in differential diagnosis of a rare variant

Cutaneous Manifestation As Primary Manifestation of Carcinoma Stomach

Metastatic gastric cancer presenting as a solitary axillary cutaneous nodule

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