Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing

Fernandes, Maria G.; Silva, Lucília P. da; Marques, Alexandra P.

doi:10.1016/b978-0-12-816390-0.00017-0

Cited by 10 publications

(3 citation statements)

References 146 publications

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“…Additionally, there is an excessive proliferation and abnormal differentiation of keratinocytes that compromises the function of the intercellular barrier and ECM remodeling by fibroblasts [263]. Many investigations have highlighted that various cell types within the skin can perceive mechanical cues [264,265]. However, our understanding of the precise role played by mechanical signals and mechano-transduction in the development of skin inflammation remains limited.…”

Section: Consideration Of Nz@hydrogels With Mechanobiological Functionsmentioning

confidence: 99%

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Kurian,

Singh,

Sagar

et al. 2024

Nano-Micro Lett.

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Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients and the healthcare system. Conventional therapies, such as corticosteroids and nonsteroidal anti-inflammatory drugs, are limited in efficacy and associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise in addressing these challenges. NZ-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of hydrogels. The multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and differentiation. This review highlights the current state of the art in NZ-engineered hydrogels (NZ@hydrogels) for anti-inflammatory and skin regeneration applications. It also discusses the underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, the challenges and future directions in this ground, particularly their clinical translation, are addressed. The insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels, offering new possibilities for targeted and personalized skin-care therapies.

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Section: Consideration Of Nz@hydrogels With Mechanobiological Functionsmentioning

confidence: 99%

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Kurian,

Singh,

Sagar

et al. 2024

Nano-Micro Lett.

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“…Finite element method (FEM) analysis for wounded skin tissue FEM analysis was conducted to see the difference in stress distribution with the commercial code ANSYS-Mechanical. The mechanical properties of skin are very heterogeneous not only among the different layers but also with anatomical skin region as well as other factors such as age, sex, and pathological condition 68 . Though the correct value of Young's modulus is a critical property for FEM simulation, the values may differ depending on skin locations or the test methods used for the measurement.…”

Section: Ngs and Data Analysismentioning

confidence: 99%

Differential expression of tension-sensitiveHOXgenes in fibroblasts is associated with different scar types

Kang

et al. 2023

Preprint

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A scar is considered a natural consequence of the wound-healing process. However, the mechanism by which scars form remains unclear. Here, we suggest a new mechanism of wound healing and scar formation that involves the mechanosensitive regulation of HOX genes. RNA-sequencing of fibroblasts from different types of scars revealed differential HOX gene expression. Computational simulations predicted injury-induced tension loss in the skin, and in vitro experiments revealed a negative correlation between tension and fibroblast proliferation. Remarkably, exogenous tensile stress in fibroblasts has been shown to alter HOX gene expression levels in different scar types. Overall, we propose a model for normal wound healing and scar formation and show that successful wound healing requires tensional homeostasis in the skin tissue, which is regulated by tension-sensitive HOX genes.

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“…A rigid environment activates cells towards a fibrotic phenotype, yielding disrupted ECM homeostasis and aberrant healing [2]. Fibrosis in highly tensioned tissues increases matrix deposition and remodelling [2,3]. When healing processes become skewed, leading to continuous infections, vascular dysfunction and excess inflammation delay scar maturation for extensive hypertrophic scars.…”

Section: Introductionmentioning

confidence: 99%

Tuning the Tensile and Shear Properties of a Scar Healing Composite for Mechanotherapy

Lui,

Wang,

Kan

2024

J. Compos. Sci.

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Conventional scar treatment options of single pressure garment therapy (PGT) or silicone gel sheeting (SGS, Cica-Care®, Smith and Nephew, London, UK) alone lack mechanical property tunability. This article discusses a scar healing composite (PGF-Biopor®AB, Dreve Otoplastik GmbH, Unna, Germany) and how its mechanical properties can be tuned for improved mechanotherapy. A balance between compression and tension was achieved by tuning the tensile and shear properties, facilitating tension shielding and pressure redistribution for scar therapeutics. Biopor®AB-wrapping on biaxial-tensioned pressure garment fabric (PGF) allowed compression therapy and internal pressure redistribution. The Biopor®AB surface, with a coefficient of friction close to 1, strategically localizes stress for effective tension shielding. A substantial five-fold reduction in silicone tension, amounting to 1.060 N, achieves tension shielding and pressure redistribution. Simultaneously, a dynamic internal pressure-sharing mechanism distributes 0.222 kPa from each SPK-filament bundle, effectively managing internal pressure. Alongside the principle compression-silicone dual therapy, this composite design with dynamic internal pressure sharing and mechanical property tunability provides an additional pressure-relieving strategy for multiple scar therapeutics.

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Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing

Cited by 10 publications

References 146 publications

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Differential expression of tension-sensitiveHOXgenes in fibroblasts is associated with different scar types

Tuning the Tensile and Shear Properties of a Scar Healing Composite for Mechanotherapy

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