Skin-limited idiopathic hypereosinophilic syndrome presenting with retiform purpura

Yu, Zizi; Dee, Edward Christopher; Menge, Tyler; Ward, Andrew; Song, Philip

doi:10.1016/j.jdcr.2019.06.013

Cited by 4 publications

(3 citation statements)

References 10 publications

(18 reference statements)

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“…In a series of 32 cases of I-HES, presentations on the skin were reminiscent of those reported in the L-HES variant, resembling urticarial or eczematous lesions 39 . Numerous published cases of I-HES report cutaneous vascular symptoms, including Raynaud’s phenomenon, livedo reticularis, purpura, ulceration, and necrosis 47–52 . Histopathology in several cases has confirmed the presence of eosinophilic vasculitis, proposing that it may be a significant feature of HES 48,53,54 .…”

Section: Clinical Presentation Of Hesmentioning

confidence: 92%

“…39 Numerous published cases of I-HES report cutaneous vascular symptoms, including Raynaud's phenomenon, livedo reticularis, purpura, ulceration, and necrosis. [47][48][49][50][51][52] Histopathology in several cases has confirmed the presence of eosinophilic vasculitis, proposing that it may be a significant feature of HES. 48,53,54 Eosinophilic infiltration of the hair follicle contributing to a diffuse-type hair loss has been reported as the presenting feature in 1 case of I-HES.…”

Section: Clinical Presentation Of Hesmentioning

confidence: 99%

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An Approach to Hypereosinophilic Syndrome Presenting With Cutaneous Features

Fourzali¹,

Yosipovitch²

2022

Dermatitis

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Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by persistent peripheral hypereosinophilia and eosinophilia-mediated tissue damage. Hypereosinophilic syndrome can have life-threatening effects on multiple organ systems but may initially, or in some cases solely, present with skin lesions. The clinical presentation of HES in the skin represents a diagnostic challenge for the dermatologist, because cutaneous manifestations are highly variable and may be mistaken for several dermatologic conditions. Once peripheral and tissue eosinophilia is diagnosed, the differential diagnosis is quite broad, spanning hematoproliferative disorders, infectious diseases, drug reactions, and many others. Workup and management may also present a challenge, because the prospect for organ system involvement in those with apparent skin-limited disease is unclear. This article provides a dermatology-centered approach to HES and provides a reference for the differential diagnosis, workup, and management of this complex disorder.

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Section: Clinical Presentation Of Hesmentioning

confidence: 92%

Section: Clinical Presentation Of Hesmentioning

confidence: 99%

An Approach to Hypereosinophilic Syndrome Presenting With Cutaneous Features

Fourzali¹,

Yosipovitch²

2022

Dermatitis

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“…HES can divided into many subtypes (e.g., eosinophilic granulomatosis with polyangiitis overlap, myeloid variant, lymphocytic variant, single-organ, idiopathic) [ 75 ]. Idiopathic HES is defined by the presence of: (i) long-lasting (>6 months) blood eosinophilia (>1.5 × 1053/L); (ii) organ damage and/or dysfunction that can be linked to eosinophilia and iii) lack of alternative root [ 76 ]. Cutaneous involvement is quite common, in up to 50% of the patients, but cutaneous lesions as the sole manifestations of HES are extremely rare and have been referred to as hypereosinophilic dermatitis [ 77 ].…”

Section: Hyperproliferative Diseasesmentioning

confidence: 99%

Urticaria: A Narrative Overview of Differential Diagnosis

et al. 2023

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Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less than 24 h before fading to leave normal skin. Urticaria is the consequence of mast-cell degranulation that can be caused by immunological or non-immunological mechanisms. From a clinical point of view, many skin conditions can mimic urticaria and their recognition is mandatory for a correct management and therapeutic approach. We have reviewed all of the main relevant studies which addressed differential diagnosis of urticarial, published until December 2022. The National Library of Medicine PubMed database was used for the electronic research. The present review offers a clinical narrative overview, based on the available literature, of the principal skin disorders that can be misdiagnosed as urticaria (mainly autoinflammatory or autoimmune disorders, drug-induced reactions, and hyperproliferative diseases). The aim of this review is to provide clinicians a useful tool for correctly suspecting and identifying all of these conditions.

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The role of eosinophils in the differential diagnosis of inflammatory skin diseases

Caro-Chang¹,

Fung²

2023

Human Pathology

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Skin-limited idiopathic hypereosinophilic syndrome presenting with retiform purpura

Cited by 4 publications

References 10 publications

An Approach to Hypereosinophilic Syndrome Presenting With Cutaneous Features

An Approach to Hypereosinophilic Syndrome Presenting With Cutaneous Features

Urticaria: A Narrative Overview of Differential Diagnosis

The role of eosinophils in the differential diagnosis of inflammatory skin diseases

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