Skin Laser Treatments Enhancing Transdermal Delivery of ALA

Gómez, Clara; Costela, Á.; García‐Moreno, Inmaculada; Llanes, Felipe; Teijón, José M.; Blanco, María Dolores Valdueza

doi:10.1002/jps.22270

Cited by 20 publications

(11 citation statements)

References 39 publications

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“…Further contributing to this field of research is the investigation on the influence of infrared radiation from the erbium:yttrium-aluminum-garnet (Er:YAG) laser (λ=2940nm), and visible from the 2nd harmonic of a neodymium:yttrium-aluminum-garnet (Nd:YAG) laser (λ=532nm) on transdermal delivery of 5-aminolevulinic acid (ALA). Gomez et al, reported that laser pretreatment enhanced the delivery of ALA through the skin by SC ablation [80]. Similarly fractional laser pretreatment by Er:YAG laser (MCL 30 Dermablate) at lower fluences also significantly enhanced the penetration of ALA [81].…”

Section: Laser Technology and Thermal Ablationmentioning

confidence: 95%

Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

Shaji¹,

Varkey²

2012

CDTH

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Transdermal delivery offers opportunities for inventive, challenging and valuable research with patient benefits. However, the prominent challenge in designing transdermal drug delivery systems is to overcome the natural transport barrier of the skin, the stratum corneum. Several physical and chemical enhancement techniques have been investigated in the last decade to breach the skin barrier and assist the transport of macromolecules across skin. Recent technological advances in this field include novel combination strategies of penetration enhancement techniques, microneedle array designs, needle-free technologies, nanocarriers, metered dose and microstructured transdermal systems. The present review reports on recent advances in physical approaches towards enhanced transdermal penetration. Enhancement strategies comprehensively covered in this review emphasize the significant achievements gained through successful transdermal delivery of hydrophilic macromolecules, vaccines, proteins, peptides, oligonucleotides, fluorescent dyes and plasmid delivery. Some commercially available technologies for transdermal delivery have also been covered. These novel technologies hold immense potential to advance further into clinical practice and enable better therapeutic applications and prophylactic interventions for various diseases.

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Section: Laser Technology and Thermal Ablationmentioning

confidence: 95%

Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

Shaji¹,

Varkey²

2012

CDTH

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“…Transdermal delivery of 5-aminolevulinic acid was envisaged with laser (Er:YAG and Nd:YAG)-assisted method in order to avoid its poor permeability across intact skin. The drug permeation was found to be increased in laser-ablated skin and the highest flux enhancement of 200.3-fold was observed for the laser wavelength of 2940 nm and fluence of 1.6 J/cm 2 compared with laser-untreated skin [110]. Presently, small interfering RNA (siRNA)-based therapy is being widely used to treat various heritable skin disorders such as actinic dermatitis, actinic keratosis, and skin cancer.…”

Section: Laser Thermal Ablationmentioning

confidence: 99%

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products

Parhi

Mandru

2020

Drug Deliv. and Transl. Res.

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Traditionally, the skin is considered as a protective barrier which acts as a highly impermeable region of the human body. But in recent times, it is recognized as a specialized organ that aids in the delivery of a wide range of drug molecules into the skin (intradermal drug delivery) and across the skin into systemic circulation (transdermal drug delivery, TDD). The bioavailability of a drug administered transdermally can be improved by several penetration enhancement techniques, which are broadly classified into chemical and physical techniques. Application of mentioned techniques together with efforts of various scientific and innovative companies had made TDD a multibillion dollar market and an average of 2.6 new transdermal drugs are being approved each year. Out of various techniques, the thermal ablation techniques involving chemicals, heating elements, lasers, and radiofrequency (RF) are proved to be more effective in terms of delivering the drug across the skin by disrupting the stratum corneum (SC). The reason behind it is that the thermal ablation technique resulted in improved bioavailability, quick treatment and fast recovery of the SC, and more importantly it does not cause any damage to underlying dermis layer. This review article mainly discussed about various thermal ablation techniques with commercial products and patents in each classes, and their safety aspects. This review also briefly presented anatomy of the skin, penetration pathways across the skin, and different generations of TDD.

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“…Laser has also been explored to ablate SC layer to facilitate transdermal drug delivery by taking advantage of its photothermal and photomechanical effects [5,6]. Different lasers, like excimer laser, Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, ruby laser, erbium:yttrium scandium gallium garnet (YSGG) laser, and CO 2 laser, have been utilized to ablate full-surface SC layer to facilitate transdermal drug delivery [5][6][7][8][9]. The degree of SC ablation was highly correlated with laser energy [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Different lasers, like excimer laser, Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, ruby laser, erbium:yttrium scandium gallium garnet (YSGG) laser, and CO 2 laser, have been utilized to ablate full-surface SC layer to facilitate transdermal drug delivery [5][6][7][8][9]. The degree of SC ablation was highly correlated with laser energy [5][6][7][8][9]. Low laser energy led to inefficient SC ablation, while high laser energy caused overt skin reactions [10].…”

Section: Introductionmentioning

confidence: 99%

Laser facilitates week-long sustained transdermal drug delivery at high doses

Kakar

et al. 2020

Journal of Controlled Release

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Traditional patches are most successful in transdermal delivery of low-dose hydrophobic drugs. Week-long transdermal delivery of high-dose hydrophilic drugs remains a big challenge. This study explored ablative fractional laser (AFL) to assist 3-day to weeklong sustained transdermal delivery of powder hydrophilic drugs in murine models. Bulk drug powder was coated into reservoir patches followed by topical application onto AFLtreated skin. Water evaporated from AFL-generated skin microchannels (MCs) gradually dissolve topical drug powder to elicit multi-day sustained drug delivery. Using sulforhodamine b, zidovudine, and bovine serum albumin as model hydrophilic drugs, we found tapped coating could coat 10-20 mg drug per 0.5 cm 2 reservoir patch to elicit 3-day sustained delivery, while compression coating could coat ~35-70 mg drug per 0.5 cm 2 reservoir patch to elicit week-long sustained delivery. Besides sustained drug delivery, AFL-assisted powder reservoir patch delivery also showed a good safety. AFLgenerated skin MCs resealed in 1-2 days and completely recovered in 3 days after the week-long sustained delivery. AFL-assisted powder reservoir patch delivery involves no complex powder formulation and only requires incorporation of highly water-soluble mannitol or a similar excipient to elicit the high-efficient delivery. Enlarging reservoir patch size to 10 cm 2 can conveniently expands the delivery capacity to gram scale. To our knowledge, this is the first time that high-dose week-long sustained transdermal delivery of hydrophilic drugs was achieved via a simple laser-based powder delivery platform.

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Skin Laser Treatments Enhancing Transdermal Delivery of ALA

Cited by 20 publications

References 39 publications

Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products

Laser facilitates week-long sustained transdermal drug delivery at high doses

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