Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

Shaji, HJessy; Varkey, Dhanila

doi:10.2174/157488512803988030

“…Tattooing is a minimally invasive mechanical injection method that perforates the skin tissue. Alternative methods can be utilized to deliver the dermal sensors to the dermis without tissue damage . For example, microjet injection can deliver pigment solutions at a high‐speed through a nozzle orifice.…”

Section: Discussionmentioning

confidence: 99%

Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

Yetisen

¹

,

Moreddu

²

,

Seifi

³

et al. 2019

View full text Add to dashboard Cite

Tattooing is aubiquitous body modification involving the injection of ink and/or dye pigments into the dermis. Biosensors in the form of tattoos can be used to monitor metabolites in interstitial fluid. Here,m inimally invasive, injectable dermal biosensors were developed for measuring pH, glucose,a nd albumin concentrations.T he dermal pH sensor was based on methyl red, bromothymol blue,a nd phenolphthalein, which responded to ap Hr ange from 5.0 to 9.0. The dermal glucose sensor consisted of glucose oxidase, 3,3',5,5'-tetramethylbenzidine,a nd peroxidase that detected concentrations up to 50.0 mmol L À1 .T he dermal albumin sensor consisted of 3',3'',5',5''-tetrachlorophenol-3,4,5,6-tetrabromosulfophthalein to measure concentrations up to 5.0 gL À1 .T he sensors were multiplexed in ex vivo skin tissue and quantitative readouts were obtained using as martphone camera. These sensors can be used to manage of acid-base homeostasis,diabetes,and liver failure in point-of-care settings.

show abstract

“…[65] Meloxicam exhibited antiradical potential and also reduced the levels of reactive oxidants. [66] Iron chelation assay was employed to investigate the Fe 2+ chelating potential of meloxicam and its complexes. This assay measured the absorbance of iron(II)phenanthroline complex (red chromophore) at 512 nm.…”

Section: In Vitro Antioxidant Potentialmentioning

confidence: 99%

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Samra

¹

,

Basra

²

2023

Applied Organom Chemis

4

0

View full text Add to dashboard Cite

In the present study, two new meloxicam complexes with Mg(II) and Sr(II) were synthesized and characterized by spectroscopic and analytical methods, that is, UV–vis, IR, 1H NMR, 13C NMR, powder XRD, SEM–EDX, and TG analysis. The biological evaluation was done by in vitro antioxidant, BSA‐binding, DNA cleavage activities, and in vivo anti‐inflammatory, analgesic, and anxiolytic methods. Furthermore, in silico docking was done with Keap1 receptor to visualize the anti‐inflammatory effect of complexes. The spectral characterization suggested that meloxicam coordinated with the metal ions by oxygen and nitrogen of amide group and thiazolyl ring (Oamide and Nthiazolyl), respectively. The SEM pictures depicted dissimilar morphologies, and the powder XRD patterns showed different crystallinities of complexes than meloxicam. TG analysis exhibited high thermal stabilities of complexes and Coats–Redfern method was employed to calculate the important thermodynamic parameters. The complexes showed effective biological activities and enhanced safety index (LD50 = 1000 mg kg−1). The Mg(II) complex revealed greatest inhibitory effects in carrageenan‐induced paw inflammation (92.85%) and in acetic acid‐induced writhing (71.05%). Furthermore, the complexes showed higher potential to bind with BSA and cleave the DNA as compared with the meloxicam. Moreover, molecular docking against Keap1 showed that Mg(II) complex inhibited Keap1 with highest docking score (6166 kcal mol−1), docking area (804.40) and ACE (−417.49 kJ mol−1) which explained its higher anti‐inflammatory effect. Mg(II) complex of meloxicam might be considered as a candidate anti‐inflammatory drug; however, more research is required to investigate their other biological potential.

show abstract

Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

Yetisen

¹

,

Moreddu

²

,

Seifi

³

et al. 2019

View full text Add to dashboard Cite

Tattooing is aubiquitous body modification involving the injection of ink and/or dye pigments into the dermis. Biosensors in the form of tattoos can be used to monitor metabolites in interstitial fluid. Here,m inimally invasive, injectable dermal biosensors were developed for measuring pH, glucose,a nd albumin concentrations.T he dermal pH sensor was based on methyl red, bromothymol blue,a nd phenolphthalein, which responded to ap Hr ange from 5.0 to 9.0. The dermal glucose sensor consisted of glucose oxidase, 3,3',5,5'-tetramethylbenzidine,a nd peroxidase that detected concentrations up to 50.0 mmol L À1 .T he dermal albumin sensor consisted of 3',3'',5',5''-tetrachlorophenol-3,4,5,6-tetrabromosulfophthalein to measure concentrations up to 5.0 gL À1 .T he sensors were multiplexed in ex vivo skin tissue and quantitative readouts were obtained using as martphone camera. These sensors can be used to manage of acid-base homeostasis,diabetes,and liver failure in point-of-care settings.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

show abstract

Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

Cited by 7 publications

References 113 publications

Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

Synthesis, spectroscopic, in vitro, in vivo biological evaluation, and in silico docking analysis of new meloxicam metal complexes

Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

Contact Info

Product

Resources

About