Skin Infections Caused by Staphylococcus aureus

Giudice, P. Del

doi:10.2340/00015555-3466

Cited by 70 publications

(48 citation statements)

References 77 publications

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“…Bacterial infections are the result of pathogenic bacteria entering and multiplying in the human body; these are a major deleterious factor in some infections ( Anderson and Kendall, 2017 ; Martin and Bachman, 2018 ). For example, the gram-positive bacterium Staphylococcus aureus is a human pathogen ( Kimmig et al, 2021 ) that is constantly a source of skin infections, lung infections, gastroenteritis, and urinary tract infections ( Thomer et al, 2016 ; Del Giudice, 2020 ). Over the years, researchers have observed that antibacterial substances can be isolated from endophytic fungi of various medicinal plants ( Pinheiro et al, 2017 ; Nischitha and Shivanna, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Diversity, Chemical Constituents, and Biological Activities of Endophytic Fungi Isolated From Ligusticum chuanxiong Hort

et al. 2021

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The objective of this study was to evaluate the diversity of endophytic fungi of different parts of Ligusticum chuanxiong Hort (CX) and further characterize their biological activities and identify chemical compounds produced by these endophytic fungi. A total of 21 endophytic fungi were isolated and identified from CX. Penicillium oxalicum, Simplicillium sp., and Colletotrichum sp. were identified as promising strains by the color reaction. Comparing different organic extracts of the three strains, it was observed that the ethyl acetate extract of Penicillium oxalicum and Simplicillium sp. and the n-butanol extract of Colletotrichum sp. showed significant antioxidant and antibacterial activities. The ethyl acetate extracts of Penicillium oxalicum had outstanding antioxidant and antibacterial effects, and its radical scavenging rates for ABTS and DPPH were 98.43 ± 0.006% and 90.11 ± 0.032%, respectively. At the same time, their IC50 values were only 0.18 ± 0.02 mg/mL and 0.04 ± 0.003 mg/mL. The ethyl acetate extract of Penicillium oxalicum showed MIC value of only 0.5 mg/mL against Escherichia coli and Staphylococcus aureus. By liquid chromatography-mass spectrometry (LC-MS), we found that Penicillium oxalicum could produce many high-value polyphenols, such as hesperidin (36.06 μmol/g), ferulic acid (1.17 μmol/g), and alternariol (12.64 μmol/g), which can be a potential resource for the pharmaceutical industry. In conclusion, these results increase the diversity of CX endophytic fungi and the antioxidant and antibacterial activities of their secondary metabolites.

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Section: Introductionmentioning

confidence: 99%

Diversity, Chemical Constituents, and Biological Activities of Endophytic Fungi Isolated From Ligusticum chuanxiong Hort

et al. 2021

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“…Empiric antibiotic such as Trimethoprim-Sulfamethoxazole or Doxycycline is recomended for moderate purulent SSTIs and Vancomycin or Daptomycin for severe purulent SSTIs. 9,10 In this case, the location of abscesses is on the face area and there was systemic signs of infection such as fever, increase heart rate, fatigue and increased leukocyte count (neutrophil dominant) so it classified to moderate purulent SSTIs. We did incision and drainage for the abscesses and continued with pus culture and sensitivity test to identify the microbe and determine the antibiotic.…”

Section: Discussionmentioning

confidence: 99%

Facial Abscess due to Staphylococcus aureus in Patient with Type 2 Diabetes Mellitus: Case Report

Maharani

Novida

2021

BHSJ

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Diabetes mellitus (DM) is a chronic disease with an increasing frequency over the last decade. DM patient has higher risk of infection than people without diabetes. Several literatures suggest a strong positive correlation between hyperglycemia and skin infections. Skin and soft tissue infections (SSTIs), including abscess which commonly caused by Staphylococcus aureus, could lead to severe and life-threatening infections. The correct diagnosis and effective management therapy should be needed to prevent further complications and reduce morbidity and mortality. We report a case about facial abscess caused by S. aureus in diabetic patient that healed after got incision drainage and antibiotics.

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“…S. aureus is one of the main biofilm-forming pathogens found on the skin. This strain is an opportunistic microbe that can generate abscesses, cellulitis, folliculitis, and lymphangitis [31]. The drug-resistant S. aureus has a high probability of establishing a biofilm for developing into persistent and recurrent infections [9].…”

Section: Cutaneous Microbiomementioning

confidence: 99%

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

et al. 2021

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Biofilm formation is an important virulence factor for the opportunistic microorganisms that elicit skin infections. The recalcitrant feature of biofilms and their antibiotic tolerance impose a great challenge on the use of conventional therapies. Most antibacterial agents have difficulty penetrating the matrix produced by a biofilm. One novel approach to address these concerns is to prevent or inhibit the formation of biofilms using nanoparticles. The advantages of using nanosystems for antibiofilm applications include high drug loading efficiency, sustained or prolonged drug release, increased drug stability, improved bioavailability, close contact with bacteria, and enhanced accumulation or targeting to biomasses. Topically applied nanoparticles can act as a strategy for enhancing antibiotic delivery into the skin. Various types of nanoparticles, including metal oxide nanoparticles, polymeric nanoparticles, liposomes, and lipid-based nanoparticles, have been employed for topical delivery to treat biofilm infections on the skin. Moreover, nanoparticles can be designed to combine with external stimuli to produce magnetic, photothermal, or photodynamic effects to ablate the biofilm matrix. This study focuses on advanced antibiofilm approaches based on nanomedicine for treating skin infections. We provide in-depth descriptions on how the nanoparticles could effectively eliminate biofilms and any pathogens inside them. We then describe cases of using nanoparticles for antibiofilm treatment of the skin. Most of the studies included in this review were supported by in vivo animal infection models. This article offers an overview of the benefits of nanosystems for treating biofilms grown on the skin.

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Skin Infections Caused by Staphylococcus aureus

Cited by 70 publications

References 77 publications

Diversity, Chemical Constituents, and Biological Activities of Endophytic Fungi Isolated From Ligusticum chuanxiong Hort

Diversity, Chemical Constituents, and Biological Activities of Endophytic Fungi Isolated From Ligusticum chuanxiong Hort

Facial Abscess due to Staphylococcus aureus in Patient with Type 2 Diabetes Mellitus: Case Report

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

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