Skin Grafting at the Johns Hopkins Hospital

Davis, John Staige

doi:10.1097/00000658-190909000-00002

Cited by 71 publications

(56 citation statements)

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“…115 Amniotic membranes were first used over a century ago as biological dressings for skin wounds. 117 This practice continues, highlighting the safety of these cells as a therapeutic for human disease. 118 Unlike MSCs, isolation of human amnion epithelial cells (hAECs) from a single placenta yields enough cells for administration to multiple patients.…”

Section: Human Amnion Epithelial Cellsmentioning

confidence: 99%

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies

Papagianis

Pillow

Moss

2019

Paediatric Respiratory Reviews

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Section: Human Amnion Epithelial Cellsmentioning

confidence: 99%

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies

Papagianis

Pillow

Moss

2019

Paediatric Respiratory Reviews

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“…Actually, the therapeutic use of amniotic membrane has been studied for decades. Davis first reported in 1910 the use of fetal membranes as surgical materials in skin transplantation performed on 550 patients [30]. Amniotic membranes showed anti-inflammatory [31]–[33], antimicrobial [34], antifibroblastic [35] and low immunogenicity properties [36], [37].…”

Section: Introductionmentioning

confidence: 99%

Synthetic Bone Substitute Engineered with Amniotic Epithelial Cells Enhances Bone Regeneration after Maxillary Sinus Augmentation

et al. 2013

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BackgroundEvidence has been provided that a cell-based therapy combined with the use of bioactive materials may significantly improve bone regeneration prior to dental implant, although the identification of an ideal source of progenitor/stem cells remains to be determined.AimIn the present research, the bone regenerative property of an emerging source of progenitor cells, the amniotic epithelial cells (AEC), loaded on a calcium-phosphate synthetic bone substitute, made by direct rapid prototyping (rPT) technique, was evaluated in an animal study.Material And MethodsTwo blocks of synthetic bone substitute (∼0.14 cm3), alone or engineered with 1×106 ovine AEC (oAEC), were grafted bilaterally into maxillary sinuses of six adult sheep, an animal model chosen for its high translational value in dentistry. The sheep were then randomly divided into two groups and sacrificed at 45 and 90 days post implantation (p.i.). Tissue regeneration was evaluated in the sinus explants by micro-computer tomography (micro-CT), morphological, morphometric and biochemical analyses.Results And ConclusionsThe obtained data suggest that scaffold integration and bone deposition are positively influenced by allotransplantated oAEC. Sinus explants derived from sheep grafted with oAEC engineered scaffolds displayed a reduced fibrotic reaction, a limited inflammatory response and an accelerated process of angiogenesis. In addition, the presence of oAEC significantly stimulated osteogenesis either by enhancing bone deposition or making more extent the foci of bone nucleation. Besides the modulatory role played by oAEC in the crucial events successfully guiding tissue regeneration (angiogenesis, vascular endothelial growth factor expression and inflammation), data provided herein show that oAEC were also able to directly participate in the process of bone deposition, as suggested by the presence of oAEC entrapped within the newly deposited osteoid matrix and by their ability to switch-on the expression of a specific bone-related protein (osteocalcin, OCN) when transplanted into host tissues.

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“…3 Elsewhere, cryopreserved amniotic tissue has been used to treat wounds in different types of tissue including tendon 4,5 and nerve repair. 6,7 AM was used to cover open wounds as early as 1910, 8 and has also been used on wounds caused by many other aetiologies such as venous leg ulcers, [9][10][11][12] pressure ulcers 9,[13][14][15] , diabetes mellitus, 15 trauma 15, 16 and burns. [17][18][19][20][21][22] While the clinical use of AM is well documented, the use of umbilical cord (UC) tissue in this setting is relatively new.…”

mentioning

confidence: 99%

Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane/chorion tissue

et al. 2014

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Skin Grafting at the Johns Hopkins Hospital

Cited by 71 publications

References 0 publications

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies

Synthetic Bone Substitute Engineered with Amniotic Epithelial Cells Enhances Bone Regeneration after Maxillary Sinus Augmentation

Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane/chorion tissue

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