Skin fragility syndrome in a cat with cholangiohepatitis and hepatic lipidosis

Abstract

A case of acquired skin fragility syndrome associated with hepatic disease in a 9-year-old, spayed female, domestic shorthair cat is described. The cat was admitted to the veterinary hospital of the University of São Paulo (Brazil) with a 6-week history of vomiting, inappetence and weight loss. Remarkable signs were weakness, lethargy and profound jaundice that had been present for 10 days according to the owner. On completion of the physical examination, when the cat was gently manipulated for blood collection the thoracic limb and interscapular skin tore. Liver enzymes and bilirubin levels were all above the normal range. On histological examination of skin and liver, Masson's trichrome stain showed collagen fibre alteration and major hepatocyte abnormalities. Findings were consistent with feline skin fragility syndrome associated with cholangiohepatitis and hepatic lipidosis.

PlasmaACTHPrecursors in Cats with Pituitary‐Dependent Hyperadrenocorticism

“…One had a potbellied appearance and acquired skin fragility, which is rarely observed in contexts other than HAC in cats. It has occasionally been reported after the use of progestagens, or in the contexts of DM without documented HAC, disseminated histoplasmosis, and various biliary and hepatic diseases . Routine biochemistry and hematologic examination, and complete ultrasound examination of the abdomen identified none of these features in this cat, other than DM.…”

“…It has occasionally been reported after the use of progestagens, or in the contexts of DM without documented HAC, disseminated histoplasmosis, and various biliary and hepatic diseases. [41][42][43][44] Routine biochemistry and hematologic examination, and complete ultrasound examination of the abdomen identified none of these features in this cat, other than DM. The 2nd cat was the only animal in group 1 to have a plasma ACTH precursor concentration below the lower limit of quantification of the assay.…”

Skin fragility syndrome in a cat with multicentric follicular lymphoma

“…7,8 Fewer than 12 cases of FSFS have been described in the literature. [9][10][11][12][13][14][15][16][17][18][19] All occurred in middleaged-to-old cats with no history of dermatological signs before onset. In most of these cases, FSFS was observed in association with a serious disease, as observed here.…”

“…In most of these cases, FSFS was observed in association with a serious disease, as observed here. 10,11,[17][18][19][20] The most common cause of acquired FSFS is spontaneous or iatrogenic hyperadrenocorticism. 2,20,21 The clinical signs displayed by cats with feline hyperadrenocorticism include poorly-controlled diabetes mellitus associated with polyuria and polydipsia, weight loss, polyphagia, abdominal distension, muscle weakness and lethargy.…”

Reversible and cachexia‐associated feline skin fragility syndrome in three cats

“…[5][6][7][8][9] It also has been reported in association with different diseases where the pathogenesis is not clear including hepatic lipidosis, feline infectious peritonitis (FIP), cholangiohepatitis, cholangiocarcinoma and multicentric lymphoma. 4,[10][11][12][13] To the best of the authors' knowledge, histopathological descriptions postrecovery are not available due to the fact that cats usually don't recover or are euthanized shortly after diagnosis. There is one case of a reversible defect in a cat experimentally receiving phenytoin.…”