Reversible and cachexia‐associated feline skin fragility syndrome in three cats

Furiani, Nicla; Porcellato, Ilaria; Brachelente, Chiara

doi:10.1111/vde.12457

Cited by 6 publications

(8 citation statements)

References 13 publications

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“…As a result, the skin becomes thin, with reduced elasticity, and it readily bruises and tears with normal handling or minimal trauma. 4 , 9 On histopathology and electron microscopy, this manifests as a thin epidermis and atrophy of the dermis, with disorganised collagen fibres that consist of loosely packed and variably sized fibrils. 9 , 10 Furthermore, chronic elevated cortisol can result in delayed wound healing.…”

Section: Discussionmentioning

confidence: 99%

Skin fragility in a cat presenting with pituitary-dependent hyperadrenocorticism

Hardy¹,

Gil-Morales²,

Maunder³

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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Case summary A case of skin fragility in an 8-year-old domestic shorthair cat with pituitary-dependent hyperadrenocorticism is described. The cat was referred to the Feline Centre at Langford Small Animal Hospital with a 2-month history of multiple skin wounds with no known traumatic aetiology. A low-dose dexamethasone suppression test was performed before referral, which was consistent with hyperadrenocorticism. On presentation, the cat had multiple cutaneous lacerations and patchy areas of alopecia. CT was performed, which revealed a pituitary mass most consistent with pituitary-dependent hyperadrenocorticism. Treatment with oral trilostane (Vetoryl; Dechra) was commenced and clinical improvement was observed; however, further extensive skin lesions as a consequence of her skin fragility resulted in euthanasia. Relevance and novel information Hyperadrenocorticism is an uncommon endocrinopathy of cats; however, it is an important differential for skin thinning and non-healing wounds. Skin fragility remains an important factor in the consideration of appropriate treatment protocols and ongoing quality of life in these patients.

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Section: Discussionmentioning

confidence: 99%

Skin fragility in a cat presenting with pituitary-dependent hyperadrenocorticism

Hardy¹,

Gil-Morales²,

Maunder³

et al. 2023

Journal of Feline Medicine and Surgery Open Reports

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“…Rarely, AFSFS may be reversible with correction of the underlying or concurrent disease process. 1,5 In a young cat, collagen dysplasia (CD) (aka cutaneous asthenia, dermatosporaxis or Ehlers-Danlos syndrome) is a possible differential diagnosis, but signalment and history usually allow for differentiation. [8][9][10] In CD the skin is generally hyperextensible, which is not a feature of AFSFS, and reportedly a skin extensibility index of >19% is diagnostic.…”

Section: Diagnosis and Discussionmentioning

confidence: 99%

“…In inflammatory and catabolic states (as seen in diabetes mellitus in people) upregulation of MMPs may be a potential cause for collagen fragmentation/dissolution. Rarely, AFSFS may be reversible with correction of the underlying or concurrent disease process 1,5 …”

Section: Diagnosis and Discussionmentioning

confidence: 99%

“…Few reports have documented other comorbidities or predisposing conditions including feline infectious peritonitis, cholangiohepatitis, cholangiocarcinoma, lymphoma, histoplasmosis and hepatic lipidosis. [1][2][3][4][5][6][7][8] The pathogenesis of AFSFS is ultimately unknown. Matrix metalloproteinases (MMPs), endogenous collagenases and elastases may be present at constitutive levels leading to collagen loss without replacement over time.…”

Section: Diagnosis and Discussionmentioning

confidence: 99%

“…Hyperadrenocorticism and diabetes mellitus are most frequently implicated, as in the present case. Few reports have documented other comorbidities or predisposing conditions including feline infectious peritonitis, cholangiohepatitis, cholangiocarcinoma, lymphoma, histoplasmosis and hepatic lipidosis 1–8 . The pathogenesis of AFSFS is ultimately unknown.…”

Section: Diagnosis and Discussionmentioning

confidence: 99%

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Wounds in a 14‐year‐old cat with diabetes mellitus

Bradley

Volk

Brisson

et al. 2020

Veterinary Dermatology

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A 14-year-old male castrated domestic short hair cat was presented to an emergency service for skin wound and respiratory distress. The cat had been treated for diabetes mellitus for several months with three units of glargine insulin (Lantus, Sanofi; Paris, France) twice daily. One week before the emergency presentation, a primary care veterinarian noted decreased skin turgor, and treated the cat for a urinary tract infection with injectable cefovecin (dose unknown; Zoetis; Parsippany, NJ, USA). Daily subcutaneous fluid administration (Ringer's lactate solution, Dechra; Overland Park, KS, USA) was performed at home by the owner. Upon presentation the cat was tachypneic (60 breaths per minute) and dyspneic. A 2 x 3 cm wound was located on the dorsal thorax with minimal bleeding and thin pliable edges (Figure 1). Similar wounds were noted

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Wounds

2019

Common Clinical Presentations in Dogs and Cats

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Reversible and cachexia‐associated feline skin fragility syndrome in three cats

Abstract: To the best of the authors' knowledge, this is the first report describing a reversible, nonsteroid-induced FSFS, associated with rapidly developing cachexia in cats.

Cited by 6 publications

References 13 publications

Skin fragility in a cat presenting with pituitary-dependent hyperadrenocorticism

Skin fragility in a cat presenting with pituitary-dependent hyperadrenocorticism

Wounds in a 14‐year‐old cat with diabetes mellitus

Wounds

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