Skin Delivery of Caffeine Contained in Biofunctional Textiles

Rubió, Laura; Alonso, Cristina; Coderch, L.; Parra, J. L.; Martı́, Meritxell; Cebrián, Juan; Navarro, Juan Antonio Micó; Lis, Manel; Valldeperas, J.

doi:10.1177/0040517509358798

Cited by 28 publications

(18 citation statements)

References 10 publications

(13 reference statements)

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“…Using the in vitro methodology of percutaneous absorption, it is possible to detect the amount of the active principle that penetrates each skin layer from a given cosmeto-textile [27]. It is reasonable to assume that the reservoir capacity of a cosmeto-textile, close contact with the skin and the corresponding skin occlusion may be the main factors that determine how an active principle (e.g., GA) crosses the skin barrier, located in the stratum corneum, and penetrates the different compartments of the skin.…”

Section: /12mentioning

confidence: 99%

Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid

Alonso

Martı́

Barba

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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In this work, the antioxidant gallic acid (GA) has been encapsulated in microspheres prepared with poly-ε-caprolactone (PCL) and incorporated into polyamide (PA) obtaining the cosmeto-textile. The topical application of the cosmeto-textile provides a reservoir effect in the skin delivery of GA. The close contact of the cosmeto-textile, containing microsphere-encapsulated GA (ME-GA), with the skin and their corresponding occlusion, may be the main reasons that explain the crossing of active principle (GA) through the skin barrier, located in the stratum corneum, and its penetration into the different compartments of the skin, epidermis and dermis. An ex vivo assessment was performed to evaluate the antioxidant effect of the ME-GA on the stratum corneum (SC) using the thiobarbituric acid-reactive species (TBARS) test. The test is based on a non-invasive ex vivo methodology that evaluates lipid peroxides formed in the outermost layers of the SC from human volunteers after UV radiation to determine the effectiveness of an antioxidant. In this case, a ME-GA cosmeto-textile or ME-GA formulation were applied to the skin in vivo and lipid peroxidation (LPO) in the horny layer were determined after UV irradiation. This methodology may be used as a quality control tool to determine ex vivo the percentage of LPO inhibition on human SC for a variety of antioxidants that are topically applied, in this case GA. Results show that LPO formation was inhibited in human SC when GA was applied directly or embedded in the cosmeto-textile, demonstrating the effectiveness of both applications. The percentage of LPO inhibition obtained after both topical applications was approximately 10% for the cosmeto-textile and 41% for the direct application of microspheres containing GA. This methodology could be used to determine the effectiveness of topically applied antioxidants encapsulated in cosmeto-textiles on human SC.

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Section: /12mentioning

confidence: 99%

Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid

Alonso

Martı́

Barba

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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“…According to the OECD methodology [20], the skin penetration studies were performed for 24 h of close contact between the textile and the skin. To increase the contact pressure between the textile fabric and skin, permeation experiments were also carried out by placing a steel cylinder on the textile-skin substrate at a constant pressure in accordance with standard conditions (125 g/cm 2 ) (ISO 105-E04, 1996) [21] (see Figure 1). …”

Section: Methodsmentioning

confidence: 99%

Cosmetotextiles with Gallic Acid: Skin Reservoir Effect

Martı́

Alonso

Martínez

et al. 2013

Journal of Drug Delivery

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The antioxidant gallic acid (GA) has been incorporated into cotton (CO) and polyamide (PA) through two different vehicles, that is, liposomes and mixed micelles, and their respective absorption/desorption processes have been studied. Moreover, in vitro percutaneous absorption tests of different cosmetotextiles have been performed to demonstrate antioxidant penetration within the layers of the skin. When GA was embedded into the cosmetotextiles, it always promoted a reservoir effect that was much more marked than that observed for polyamide. Similar penetration was observed in the textiles treated with GA in mixed micelles or liposomes in such compartments of the skin as the stratum corneum, epidermis, and even the dermis. GA was detected in receptor fluid only when CO was treated with MM. This methodology may be useful in verifying how encapsulated substances incorporated into textile materials penetrate human skin. Indeed, such materials can be considered strategic delivery systems that release a given active compound into the skin at specific doses.

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“…Differences in the application time on human ex vivo skin (24 h) could also account for this finding. Rubio et al [32] reported a percutaneous absorption of caffeine into the tissue of 1% by applying a liquid caffeine formulation. It can be summarized that the achieved recovery in the dermis is comparable to the published data.…”

Section: Study Design B: Investigation Of the Influence Of Follicularmentioning

confidence: 99%

Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin

Klein

Lubda

Taghavi

et al. 2020

Skin Pharmacol Physiol

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Aim: The skin represents a drug delivery portal. The establishment of a skin model capable of distinguishing between the follicular and intercellular penetration pathways remains a challenge. The study described herein was aimed at showing the influence of two nail varnishes as closure material and four application techniques to spread the active pharmaceutical ingredient (API) on a successful follicular closure without inducing penetration-enhancing effects. Materials and Methods: For all experiments, ex vivo porcine ear skin was used. In study design A, a standard and a solvent-free nail varnish were compared. It was tested whether the different application techniques (spreading with pipette, careful finger massage, 5-Hz finger massage, 5-Hz automatic massage) potentially destroy an intact follicular closure. Laser scanning microscopy imaging was used to measure if the model drug (fluorescein sodium salt) penetrated into the Anna Lena Klein and Markus Lubda share first authorship. Klein et al.study clearly demonstrates that a standard nail varnish in combination with a gentle application technique of the API provides a secure follicular closure. The presented study only investigated the closure for the substances caffeine and fluorescein sodium salt. The results might not be transferable to all kinds of APIs.

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Skin Delivery of Caffeine Contained in Biofunctional Textiles

Cited by 28 publications

References 10 publications

Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid

Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid

Cosmetotextiles with Gallic Acid: Skin Reservoir Effect

Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin

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