Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines

Marcy, R; Quermonne, M. A.; Raoul, Jean‐Luc; Nammathao, Bounsay; Smida, Alí

doi:10.1016/0278-5846(85)90191-5

Cited by 8 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Benzodiazepines have been linked to a lack of the SCR (Marcy et al, 1985;Siepmann et al, 2007), with more extinction and habituation (Graeff et al, 2003). In our study, the results showed no link between SCR and benzodiazepine treatments.…”

Section: Controls Patientscontrasting

confidence: 46%

'What is more familiar than I? Self, other and familiarity in schizophrenia

Ameller

Dereux

Dubertret

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

Section: Controls Patientscontrasting

confidence: 46%

'What is more familiar than I? Self, other and familiarity in schizophrenia

Ameller

Dereux

Dubertret

et al. 2015

Schizophrenia Research

View full text Add to dashboard Cite

“…The early work of Lader (1964) with barbiturates is well known, and subsequent work with benzodiazepines has produced similar results (Frith et aI., 1984). Marcy et al (1985) have developed an animal model of benzodiazepine effects on specific EDR lability in mice. They reported a correlation between the receptor binding potency of eight benzodiazepines and the dose required to reduce specific lability by 50 percent.…”

Section: Enr Lability and Arousalmentioning

confidence: 99%

Electrodermal Response Lability-Stability: Individual Difference Correlates

Crider

1993

Progress in Electrodermal Research

View full text Add to dashboard Cite

“…The systemic administration of benzodiazepines is known to decrease brain NA turnover . The LC activity is known to receive GABAergic inhibition, and a good correlation is reported between the affinity of benzodiazepines for the GABA A receptor and the SCR habituation rate, which suggests that the anxiolytic effect of benzodiazepines is mediated by their NAergic inhibition. Clonidine, prazosin, and β‐blockers are known to be useful as anxiolitics .…”

Section: Does Noradrenergic Dysfunction Exist In Psychiatric Disorders?mentioning

confidence: 99%

Psychiatric symptoms of noradrenergic dysfunction: A pathophysiological view

Yamamoto

Shinba

Yoshii

2013

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

What psychiatric symptoms are caused by central noradrenergic dysfunction? The hypothesis considered in this review is that noradrenergic dysfunction causes the abnormalities in arousal level observed in functional psychoses. In this review, the psychiatric symptoms of noradrenergic dysfunction were inferred pathophysiologically from the neuroscience literature. This inference was examined based on the literature on the biology of psychiatric disorders and psychotropics. Additionally, hypotheses were generated as to the cause of the noradrenergic dysfunction. The central noradrenaline system, like the peripheral system, mediates the alarm reaction during stress. Overactivity of the system increases the arousal level and amplifies the emotional reaction to stress, which could manifest as a cluster of symptoms, such as insomnia, anxiety, irritability, emotional instability and exaggerated fear or aggressiveness (hyperarousal symptoms). Underactivity of the system lowers the arousal level and attenuates the alarm reaction, which could result in hypersomnia and insensitivity to stress (hypoarousal symptoms). Clinical data support the hypothesis that, in functional psychoses, the noradrenergic dysfunction is in fact associated with the arousal symptoms described above. The antinoradrenergic action of anxiolytics and antipsychotics can explain their sedative effects on the hyperarousal symptoms of these disorders. The results of animal experiments suggest that excessive stress can be a cause of long-term noradrenergic dysfunction.

show abstract

Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines

Cited by 8 publications

References 5 publications

'What is more familiar than I? Self, other and familiarity in schizophrenia

'What is more familiar than I? Self, other and familiarity in schizophrenia

Electrodermal Response Lability-Stability: Individual Difference Correlates

Psychiatric symptoms of noradrenergic dysfunction: A pathophysiological view

Contact Info

Product

Resources

About