Electrodermal response (EDR) lability is a psychophysiological trait reflecting stable individual differences in electrodermal activation as indexed by frequency measures of phasic EDR activity. There is no consistent evidence that EDR lability reflects dispositional or clinical anxiety. However, EDR lability appears to be related to individual differences in the overt expression of emotional and antagonistic impulses. Greater EDR lability is associated with a relatively undemonstrative and agreeable disposition, whereas greater EDR stability is associated with a relatively expressive and antagonistic disposition. The inverse relationship between EDR lability and the expression of emotional and antagonistic impulses suggests that EDR lability may reflect individual differences in the effortful control of such expression. This hypothesis is consistent with cognitive effort interpretations of phasic EDR activity, with evidence of the sensitivity of phasic EDR activity to capacity-demanding tasks, and with evidence of reduced spare capacity among EDR labile individuals under cognitive challenge. Individual differences in effortful self-control may explain the association of greater EDR lability with essential hypertension and greater EDR stability with forms of antisocial behavior.