Skin color independent assessment of aging using skin autofluorescence

Koetsier, M.; Nur, Erfan; Chunmao, [No Value] Han; Lutgers, Helen L.; Links, Thera P.; Smit, Andries J.; Rakhorst, Gerhard; Graaff, Reindert

doi:10.1364/oe.18.014416

Cited by 75 publications

(76 citation statements)

References 32 publications

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“…A method to adapt the estimation of skin AF in healthy subjects for the influence of skin color is described in Koetsier et al [15] This approach is based on empirical optimization, using a sample population of non-diabetic subjects, of a set of correction parameters that are calculated from spectra in the UV-A and visible range. here, image data from additional spectral bands in the visible range could be added to the algorithm.…”

Section: Discussionmentioning

confidence: 99%

Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging

Larsson

Favilla²,

Strömberg

2017

Computers in Biology and Medicine

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We proposed a non-invasive, contact-less novel technique for quantifying fluorescent AGE deposits in skin tissue using a multi-spectral imaging camera setup (MSI) during ultraviolet (UV) exposure. Imaging involved applying a region-of-interest mask, avoiding specular reflections and a simple calibration. Results of a study conducted on 16 subjects with skin types ranging from fair to deeply pigmented skin, showed that AGE measured with MSI in forearm skin was significantly correlated with the AGE reference method (AGE Reader on forearm skin, R = 0.68, p = 0.005). AGE measured in facial skin was borderline significantly related to AGE Reader on forearm skin (R = 0.47, p = 0.078). These results support the use of the technique in devices for non-touch measurement of AGE content in either facial or forearm skin tissue over time.

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Section: Discussionmentioning

confidence: 99%

Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging

Larsson

Favilla²,

Strömberg

2017

Computers in Biology and Medicine

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“…Skin AF cannot currently be assessed in people with dark skin, which represents a significant number of patients with CKD, particularly in the United States. A method has been proposed for calculating skin AF independent of skin color, and it may be an important area of investigation for future research (44). This study was an observational study, and we are cautious in ascribing any causal relationship to these results.…”

Section: Discussionmentioning

confidence: 99%

Skin Autofluorescence and All-Cause Mortality in Stage 3 CKD

Fraser

Roderick

McIntyre

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Novel markers may help to improve risk prediction in CKD. One potential candidate is tissue advanced glycation end product accumulation, a marker of cumulative metabolic stress, which can be assessed by a simple noninvasive measurement of skin autofluorescence. Skin autofluorescence correlates with higher risk of cardiovascular events and mortality in people with diabetes or people requiring RRT, but its role in earlier CKD has not been studied.Design, setting, participants, & measurements A prospective cohort of 1741 people with CKD stage 3 was recruited from primary care between August 2008 and March 2010. Participants underwent medical history, clinical assessment, blood and urine sampling for biochemistry, and measurement of skin autofluorescence. Kaplan-Meier plots and multivariate Cox proportional hazards models were used to investigate associations between skin autofluorescence (categorical in quartiles) and all-cause mortality.Results In total, 1707 participants had skin autofluorescence measured; 170 (10%) participants died after a median of 3.6 years of follow-up. The most common cause of death was cardiovascular disease (41%). Higher skin autofluorescence was associated significantly with poorer survival (all-cause mortality, P,0.001) on KaplanMeier analysis. Univariate and age/sex-adjusted Cox proportional hazards models showed that the highest quartile of skin autofluorescence was associated with all-cause mortality (hazard ratio, 2.64; 95% confidence interval, 1.71 to 4.08; P,0.001 and hazard ratio, 1.84; 95% confidence interval, 1.18 to 2.86; P=0.003, respectively, compared with the lowest quartile). This association was not maintained after additional adjustment to include cardiovascular disease, diabetes, smoking, body mass index, eGFR, albuminuria, and hemoglobin.Conclusions Skin autofluorescence was not independently associated with all-cause mortality in this study. Additional research is needed to clarify whether it has a role in risk prediction in CKD.

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“…Erősebben pigmentált bőrű betegcsoportban a SAF értékei alacsonyabbak, kevésbé jelzik a diabeteses szövődményeket [34]. A bőrautofl uoreszcencia-mérés céljából kifejlesztett eszköz 2010-től alkalmas a bőr pigmenttartalomtól független meghatározására is egy algoritmus segítségével, így sötét (Fitzpatrik V-VI) bőrszínű páciensek esetében is alkalmazható [35].…”

Section: A Bőr-autofl Uoreszcencia éRtékét Befolyásoló Tényezőkunclassified

A bőr-autofluoreszcencia és a konvencionális glykaemiás markerek kapcsolata diabeteses betegekben

et al. 2015

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Relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetesIntroduction: Skin autofl uorescence has a well-known signifi cance for screening diabetes and early diagnosis of vascular complications. It predicts cardiovascular events better than hemoglobin A1c, hence skin autofl uorescence is a marker of cumulative tissue glycemic load whereas hemoglobin A1c refl ects changes occurring in the previous 6-8 weeks. Aim: The aim of the authors was analyze the relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetes. Method: Skin autofl uorescence measurements were performed in 2010 in 18 patients (10 men and 8 women with normal glomerular fi ltration rate; age, 61.4±13.8 years) with long term follow-up (2624 months, 476 laboratory results). Relationships between skin autofl uorescence values and fasting blood glucose, hemoglobin A1c levels and metabolic parameters obtained before and after skin autofl uorescence measurements were analysed using Spearman rank test. Results: The average skin autofl uorescence value was 2.88±0.65 arbitrary units. There were no signifi cant correlations between skin autofl uorescence and hemoglobin A1c levels obtained before (7.84±1.08%, p = 0.07) and after the skin autofl uorescence measurements (7.45±1.18%, p = 0.71). Skin autofl uorescence values also failed to show relationship with fasting blood glucose obtained before (p = 0.09) and after (p = 0.29) the skin autofl uorescence measurements. Conclusions: In patients with diabetes skin autofl uorescence may provide novel information about glycemic burden. Skin autofl uorescence values (which may presumably provide a more accurate estimation of the cardiovascular risk) do not correlate with hemoglobin A1c and fasting blood glucose Keywords: skin autofl uorescence, hemoglobin A1c, cardiovascular riskMácsai, E., Rakk, E., Miléder, M., Fulcz, Á. [Relationship between skin autofl uorescence and conventional glycemic markers in patients with diabetes]. Orv. Hetil., 2015, 156(33) EREDETI KÖZLEMÉNYRövidítések AGE = glikációs végtermékek; CABG = coronaria arteria bypass graft; CACS = coronaria arteria kalcifi kációs score; CGMS = (continuous glucose monitoring system) szövetiglü-kóz-szint monitorozása; CKD = krónikus veseelégtelenség; GFR = glomerulusfi ltrációs ráta; HbA 1c = hemoglobin-A-1c; IGT = csökkent glükóztolerancia; PAD = perifériás artériás betegség; RAGE = (receptor for AGE) glikációs végtermékek receptora; SAF = bőr-autofl uoreszcencia; T1DM = diabetes mellitus 1-es típus; T2DM = diabetes mellitus 2-es típus

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Skin color independent assessment of aging using skin autofluorescence

Cited by 75 publications

References 32 publications

Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging

Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging

Skin Autofluorescence and All-Cause Mortality in Stage 3 CKD

A bőr-autofluoreszcencia és a konvencionális glykaemiás markerek kapcsolata diabeteses betegekben

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