Skin carotenoids status as a potential surrogate marker for cardiovascular disease risk determination in middle-aged and older adults

Toh, Darel Wee Kiat; Sutanto, Clarinda; Loh, Wen Wei; Lee, Wan Yee; Yao, Yuanhang; Ong, Choon Nam; Kim, Jung Eun

doi:10.1016/j.numecd.2020.10.016

Cited by 16 publications

(11 citation statements)

References 52 publications

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“…A number of studies have shown an association between a diet that is rich in carotenoids, e.g., fruit and vegetables, and the risk of developing certain types of cancer according to the following principle: the more carotenoids in a diet, the lower the probability of cancer development [ 209 , 210 , 211 ]. The same relationship has been observed between a carotenoid-rich diet and the risk of cardiovascular [ 212 , 213 ], eye [ 214 ], and other diseases [ 11 , 215 ]. The inverse relationship for the development of lung cancer has been reported for heavy smoking individuals after supplementation of a high single dose of ß-carotene, which strongly exceeds the physiological concentration [ 68 ].…”

Section: Factors Resulting In the Reduction Of Carotenoids In The Scsupporting

confidence: 63%

Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors

et al. 2022

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The antioxidant system of the human body plays a crucial role in maintaining redox homeostasis and has an important protective function. Carotenoids have pronounced antioxidant properties in the neutralization of free radicals. In human skin, carotenoids have a high concentration in the stratum corneum (SC)—the horny outermost layer of the epidermis, where they accumulate within lipid lamellae. Resonance Raman spectroscopy and diffuse reflectance spectroscopy are optical methods that are used to non-invasively determine the carotenoid concentration in the human SC in vivo. It was shown by electron paramagnetic resonance spectroscopy that carotenoids support the entire antioxidant status of the human SC in vivo by neutralizing free radicals and thus, counteracting the development of oxidative stress. This review is devoted to assembling the kinetics of the carotenoids in the human SC in vivo using non-invasive optical and spectroscopic methods. Factors contributing to the changes of the carotenoid concentration in the human SC and their influence on the antioxidant status of the SC in vivo are summarized. The effect of chemotherapy on the carotenoid concentration of the SC in cancer patients is presented. A potential antioxidant-based pathomechanism of chemotherapy-induced hand-foot syndrome and a method to reduce its frequency and severity are discussed.

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Section: Factors Resulting In the Reduction Of Carotenoids In The Scsupporting

confidence: 63%

Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors

et al. 2022

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“…Carotenoids are present as a mini component in fruits and vegetables and also responsible for their colors red, yellow and orange. They are considered responsible for the beneficial property of vegetables and fruits in preventing human diseases like cardiovascular diseases (Toh et al, 2021).…”

Section: Carotenoids and Hypertensionmentioning

confidence: 99%

Treatment of Hypertension by Using Natural Herbs and their Mechanism of Action

Aloufi¹,

Atwan²,

Alshammari³

2022

J Biochem Technol

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“…Finally, the current evidence also underscores RS-based SCS as a promising assessment tool to evaluate policies and interventions to improve the dietary intake of fruit and vegetables for the prevention of childhood obesity and chronic diseases, such as cardiovascular disease, diabetes, and cancer. Therefore, RS-based SCS has the potential to be utilized as a non-invasive biomarker [ 75 , 76 , 77 ] and population health outcome measure for obesity, cancer, and chronic disease prevention in young children and adults.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Reflection Spectroscopy-Based Skin Carotenoid Assessment in Children

et al. 2023

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Assessing children’s skin carotenoid score (SCS) using reflection spectroscopy (RS) is a non-invasive, widely used method to approximate fruit and vegetable consumption (FVC). The aims for the current review were to (1) identify distributions of SCS across demographic groups, (2) identify potential non-dietary correlates for RS-based SCS, (3) summarize the validity and reliability of RS-based SCS assessment, and (4) conduct meta-analyses of studies examining the correlation between RS-based SCS with FVC. A literature search in eight databases in June 2021 resulted in 4880 citations and peer-reviewed publications written in English that investigated children’s (2–10 years old) SCS using RS. We included 11 studies (intervention = 3, observational = 8). Potential covariates included weight status, ethnicity, seasonal variation, age, sex, and income. Studies reported criterion validity with children’s FVC but not with plasma carotenoid. Additionally, no studies reported the reliability of RS-based SCS in children. Among the 726 children included in the meta-analysis, the correlation between RS-based SCS and FVC was r = 0.2 (p < 0.0001). RS-based SCS is a valid method to quantify skin carotenoids for children’s FVC estimation with the potential for evaluating nutrition policies and interventions. However, future research should use standardized protocol for using RS and establish how RS-based SCS can translate to the amount of daily FVC in children.

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Skin carotenoids status as a potential surrogate marker for cardiovascular disease risk determination in middle-aged and older adults

Cited by 16 publications

References 52 publications

Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors

Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors

Treatment of Hypertension by Using Natural Herbs and their Mechanism of Action

Systematic Review of Reflection Spectroscopy-Based Skin Carotenoid Assessment in Children

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